Results 31 to 40 of about 6,696 (158)

Exploring the potential mechanism of emetine against coronavirus disease 2019 combined with lung adenocarcinoma: bioinformatics and molecular simulation analyses

open access: yesBMC Cancer, 2022
Background Patients with lung adenocarcinoma (LUAD) may be more predisposed to coronavirus disease 2019 (COVID-19) and have a poorer prognosis. Currently, there is still a lack of effective anti-LUAD/COVID-19 drugs.
Kun Zhang   +5 more
doaj   +1 more source

Researches into the structure of emetine [PDF]

open access: yes, 2017
The first crude preparation of the alkaloid emetine was obtained in 1817 by Pelletier from the plant species Cephaelis ipecacuanha. Since that day many workers have turned their attentions to the structural problem presented by this alkaloid, among them ...
Battersby, Alan Rushton
core   +2 more sources

Secondary metabolites as potential drug candidates against Zika virus, an emerging looming human threat: Current landscape, molecular mechanism and challenges ahead

open access: yesJournal of Infection and Public Health, 2023
Nature has given us yet another wild card in the form of Zika virus (ZIKV). It was found in 1947, but has only recently become an important public health risk, predominantly to pregnant women and their unborn offspring. Currently, no specific therapeutic
Nabeelah Bibi Sadeer   +6 more
doaj   +1 more source

Studies on some dehydrogenation products of emetine [PDF]

open access: yes, 1953
This thesis is concerned chiefly with the study of some dehydrogenation product obtained by mild oxidation of emetine. The primary aim was to obtain information about some of the dehydrogenation products of emetine which would permit elucidation of their
Williams, Jack A.
core   +1 more source

Estudo ecogeográfico da poaia [Psychotria ipecacuanha (Brot.) Stokes] Ecogeographic study of "poaia" Psychotria ipecacuanha (Brot.) Stokes

open access: yesRevista Brasileira de Plantas Medicinais, 2009
Este estudo foi conduzido com 13 populações amostradas nos estados RJ, MG, ES e BA para a coleta de dados ecogeográficos da poaia (Psychotria ipecacuanha).
E.R. Martins   +3 more
doaj   +1 more source

Emetine and cephaeline content in plants of Psychotria ipecacuanha in Costa Rica

open access: yesRevista Colombiana de Química, 2020
The objective of this study was to identify the emetic metabolites in different parts of the P. ipecacuanha, a plant with emetic properties. Partial phytochemical analysis was performed to determine the presence of emetine and cephaeline in leaves, stems
María Catalina Rosales López   +2 more
doaj   +1 more source

Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons. [PDF]

open access: yesPLoS Pathogens, 2018
Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini.
Margaret A MacGibeny   +4 more
doaj   +1 more source

PKC Inhibits Sec61 Translocon-Mediated Sarcoplasmic Reticulum Ca2+ Leak in Smooth Muscle Cells

open access: yesFrontiers in Physiology, 2022
PKC inhibitors stimulate Ca2+ release from internal stores in diverse cell types. Our data indicate that this action cannot be explained by an increased agonist-induced IP3 production or an overloaded SR Ca2+ pool in smooth muscle cells from guinea pig ...
Adan Dagnino-Acosta   +1 more
doaj   +1 more source

A Novel Heat Shock Element (HSE) in Entamoeba histolytica that Regulates the Transcriptional Activation of the EhPgp5 Gene in the Presence of Emetine Drug

open access: yesFrontiers in Cellular and Infection Microbiology, 2017
Transcriptional regulation of the multidrug resistance EhPgp5 gene in Entamoeba histolytica is induced by emetine stress. EhPgp5 overexpression alters the chloride-dependent currents that cause trophozoite swelling, diminishing induced programmed cell ...
Alma Nieto   +4 more
doaj   +1 more source

Spectrophotofluorometric Determination of Emetine in Animal Tissues

open access: yes, 1962
A simple rapid spectrophotofluorometric method for assaying emetine in animal tissues is described. Tissue emetine concentrations have been determined in rats at intervals up to 14 days after single doses of emetine hydrochloride or emetine bismuth ...
B Davis, E G Tomich, M G Dodds
core   +1 more source

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