Results 31 to 40 of about 5,579 (176)
PKC Inhibits Sec61 Translocon-Mediated Sarcoplasmic Reticulum Ca2+ Leak in Smooth Muscle Cells
Frontiers in Physiology, 2022 PKC inhibitors stimulate Ca2+ release from internal stores in diverse cell types. Our data indicate that this action cannot be explained by an increased agonist-induced IP3 production or an overloaded SR Ca2+ pool in smooth muscle cells from guinea pig ...
Adan Dagnino-Acosta +1 more
doaj +1 more source
EMETINE MYOPATHY IN THE RAT [PDF]
British Journal of Pharmacology, 1976 (–)‐Emetine (0.25‐2.0 mg/kg i.p.) was administered to rats for up to 220 days. At doses of 1.0 mg/kg or less, the animals continued to gain weight but more slowly than the untreated control animals. The physiological changes in the muscles from these animals were minimal; there was a small reduction in both the resting membrane potential and in the ...
W G, Bradley +3 more
openaire +2 more sources
Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice
Molecular Medicine, 2016 Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by β cell destruction, insulin deficiency and hyperglycemia. Activated macrophages and autoimmune T cells play a crucial role in the pathogenesis of hyperglycemia in NOD murine ...
LaQueta K Hudson +20 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2017 Transcriptional regulation of the multidrug resistance EhPgp5 gene in Entamoeba histolytica is induced by emetine stress. EhPgp5 overexpression alters the chloride-dependent currents that cause trophozoite swelling, diminishing induced programmed cell ...
Alma Nieto +4 more
doaj +1 more source
Informatics in Medicine Unlocked, 2022 Mucormycosis has become a global issue due to its potential to infect and destroy organs, as well as its high fatality rate. Co-infecting with Covid 19 or when infecting after Covid 19, it becomes more lethal.
Anik Banik +5 more
doaj +1 more source
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine
eLife, 2014 Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies.
Wilson Wong +8 more
doaj +1 more source
Gelsolin Amyloidogenesis Is Effectively Modulated by Curcumin and Emetine Conjugated PLGA Nanoparticles. [PDF]
PLoS ONE, 2015 Small molecule based therapeutic intervention of amyloids has been limited by their low solubility and poor pharmacokinetic characteristics. We report here, the use of water soluble poly lactic-co-glycolic acid (PLGA)-encapsulated curcumin and emetine ...
Ankit Srivastava +5 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.Deep autoencoder algorithm identified TALDO1 as a key metabolic gene associated with HCC progression. TALDO1 promotes lipid synthesis and accumulation in HCC cells and participates in lipid metabolic reprogramming. TALDO1 is associated with immunosuppressive microenvironment remodelling, and targeting TALDO1 reduces the infiltration of ...
Fenglin Lv +9 more
wiley +1 more source
Synthesis of substituted allyl acetates from heterocyclic dienes by Pd-promoted arylation-acetoxylation cascade [PDF]
Journal of the Serbian Chemical Society, 2017 Pd-catalysed arylation–acetoxylation cascade, a previously reported methodology, was applied in the functionalisation of unsymmetrical dienes. Both explored classes of compounds, isoquinoline and β-carboline-derived dienes, afforded single regioisomers ...
Simić Milena R. +4 more
doaj +1 more source