Results 21 to 30 of about 6,696 (158)

Emetine in Combination with Chloroquine Induces Oncolytic Potential of HIV-1-Based Lentiviral Particles

Cells, 2022
Chloroquine and Emetine are drugs used to treat human parasitic infections. In addition, it has been shown that these drugs have an antiviral effect.
Pavel Spirin, Elena Shyrokova, Valeria Vedernikova, Timofey Lebedev, Vladimir Prassolov   +4 more
doaj   +1 more source

Deep Transfer Learning Approach for Automatic Recognition of Drug Toxicity and Inhibition of SARS-CoV-2

Viruses, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19 and is responsible for the ongoing pandemic. Screening of potential antiviral drugs against SARS-CoV-2 depend on in vitro experiments, which are based on the quantification of ...
Julia Werner, Raphael M. Kronberg, Pawel Stachura, Philipp N. Ostermann, Lisa Müller, Heiner Schaal, Sanil Bhatia, Jakob N. Kather, Arndt Borkhardt, Aleksandra A. Pandyra, Karl S. Lang, Philipp A. Lang   +11 more
doaj   +1 more source

Emetine dihydrochloride suppresses the invasiveness and motility of hepatocellular carcinoma cells through MAPK pathway inhibition and Twist1 protein destabilization. [PDF]

Sci Rep
Epithelial-mesenchymal transition (EMT) is a crucial step in the development and metastasis of cancer. Emetine was previously proposed as an antiemetic and a protein synthesis inhibitor, but its effect on cancer metastasis has not been evaluated ...
Yoon H, Kang E, Park GS, Cho S.
europepmc   +2 more sources

Puromycin reactivity does not accurately localize translation at the subcellular level

eLife, 2020
Puromycin is a tyrosyl-tRNA mimic that blocks translation by labeling and releasing elongating polypeptide chains from translating ribosomes. Puromycin has been used in molecular biology research for decades as a translation inhibitor. The development of
Syed Usman Enam, Boris Zinshteyn, Daniel H Goldman, Madeline Cassani, Nathan M Livingston, Geraldine Seydoux, Rachel Green   +6 more
doaj   +1 more source

Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidences

Molecular Biomedicine, 2020
The global pandemic of COVID-19 has attracted extensive drug searching interets for the new coronavirus SARS-CoV-2. Although currently several of clinically used “old” drugs have been repurposed to this new disease for the urgent clinical investigation ...
Aoli Wang, Yong Sun, Qingwang Liu, Hong Wu, Juan Liu, Jun He, Junling Yu, Qing Qing Chen, Yinglu Ge, Zhuhui Zhang, Chen Hu, Cheng Chen, Ziping Qi, Fengming Zou, Feiyang Liu, Jie Hu, Ming Zhao, Tao Huang, Beilei Wang, Li Wang, Wei Wang, Wenchao Wang, Tao Ren, Jing Liu, Yehuan Sun, Song Fan, Qibing Wu, Chaozhao Liang, Liangdan Sun, Bin Su, Wei Wei, Qingsong Liu   +31 more
doaj   +1 more source

Clinical efficacy of low-dose emetine for patients with COVID-19: a real-world study

Journal of Bio-X Research, 2021
. Objective:. Emetine, an isoquinoline alkaloid that is enriched at high concentrations in the lung, has shown potent in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Song Fan, Qi Zhen, Cheng Chen, Wenjun Wang, Qibing Wu, Huihui Ma, Chengyuan Zhang, Li Zhang, Baojing Lu, Huiyao Ge, Liang Yong, Bao Li, Yafen Yu, Weiwei Chen, Yiwen Mao, Guangbo Qu, Li Su, Aoli Wang, Zhen Ding, Haiwen Li, Jin Zhang, Yonglian Wang, Yufeng Gao, Xihai Xu, Zhongming Zhu, Jun Chen, Long Zhang, Hongqiang Liang, Song Wu, Meng Huang, Quan Xia, Ping Li, Yehuan Sun, Chaozhao Liang, Wei Wei, Qingsong Liu, Liangdan Sun   +36 more
doaj   +1 more source

Researches into the synthesis of some degradation products of emetine [PDF]

, 2018
The root bark of several species of the ipecacuanha plant, notably Cephaelis ipecacuanha and Psychotria acuminate, contains at least five alkaloids, of which the principal one is emetine.
Ure, George Reid
core   +2 more sources

Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer. [PDF]

Mol Oncol
Anaplastic lymphoma kinase (ALK; also known as ALK tyrosine kinase receptor) inhibitors (ALKi) are effective in treating lung cancer patients with chromosomal rearrangement of ALK.
Park SM, Haam K, Heo H, Kim D, Kim MJ, Jung HJ, Cha S, Kim M, Lee H.   +8 more
europepmc   +2 more sources

INHIBITION OF REDD1 EXPRESSION FOR THE REDUCTION OF GLUCOCORTICOID-INDUCED SIDE EFFECTS

Сибирский онкологический журнал, 2020
Glucocorticoids (GC ) have been an integral component of the treatment of leukemias and lymphomas for several decades. Specific cytotoxic effect of GC on transformed lymphoblasts mediates their use at the stage of the remission induction as well as ...
E. S. Lylova, A. V. Savinkova, E. M. Zhidkova, K. I. Kirsanov, M. G. Yakubovskaya, I. V. Budunova, E. A. Lesovaya   +6 more
doaj   +1 more source

In Silico Studies of Bioactive Compounds Selected from Four African Plants with Inhibitory Activity Against Plasmodium falciparum Dihydrofolate Reductase-Thymidylate Synthase (pfDHFR-TS) [PDF]

Journal of Advanced Pharmacy Research, 2022
Objective: This present study aims to assess in silico inhibitory potentials of bioactive compounds present in Vernonia amygdalina (Bitter leaf), Cymbopogon citratus (Lemongrass), Azadirachta indica (Neem leaf), and Carica papaya (Pawpaw leaf) against ...
Ishola Akinwumi, Ayodele Faleti, Adefolarin Owojuyigbe, Faridat Raji, Michael Alaka   +4 more
doaj   +1 more source