Results 171 to 180 of about 14,096,383 (244)

Astragaloside IV Mitigates Hepatocyte Apoptosis in Metabolic Dysfunction–Associated Fatty Liver Disease Through Inhibition of CASP3‐Dependent PARP1 Cleavage

Phytotherapy Research, EarlyView.
Astragaloside IV reduced body and liver weight, hepatic lipid accumulation, and inflammatory markers in db/db mice, and attenuated lipid accumulation and oxidative stress in FFA‐treated HepG2 cells. In both models, it reduced hepatocyte apoptosis alongside decreased CASP3 activation and PARP1 cleavage.
Fengyi Zhang, Xinhe Wang, Yahui Li, Wenlu Ma, Yaxin Chen, Yufeng Zhang, Jiayi Zhang, Xin Wang, Jingjing Pan, Yu Zhang, Ziyang Cheng, Wenbo Wang, Yujie Li   +12 more
wiley   +1 more source

Efficacy of 2 botanical aphicides, chicoric and 3,5-dicaffeoylquinic acids, on aphids susceptible and resistant to synthetic insecticides. [PDF]

J Econ Entomol
Siegwart M, Gauffre B, Lecerf E, Poëssel JL.   +3 more
europepmc   +1 more source

Salidroside Alleviates AlCl3/D‐galactose‐Induced Alzheimer's Disease‐Like Mice Neuronal Damage and Synaptic Dysfunction Through Keap1/Nrf2/GSH Signaling Axis

Phytotherapy Research, EarlyView.
Salidroside alleviates AlCl3/D‐galactose‐induced neuronal injury and synaptic dysfunction in AD‐like mice via regulation of the Keap1/Nrf2/GSH signaling axis. ABSTRACT Alzheimer's disease (AD) is associated with glutathione (GSH) depletion and redox imbalance in the brain, contributing to hippocampal neuronal damage and synaptic dysfunction and ...
Heying Cui, Yihua Han, Yanzhu Lu, Shuhua Zheng, Ruijing Zhang, Xianjing Zhang, Zheng Nan, Xiangdan Li, Songbiao Cui, Dongyuan Xu   +9 more
wiley   +1 more source

Comparative transcriptomic analyses of diploid and tetraploid citrus reveal how ploidy level influences salt stress tolerance. [PDF]

Front Plant Sci
Bonnin M, Soriano A, Favreau B, Lourkisti R, Miranda M, Ollitrault P, Oustric J, Berti L, Santini J, Morillon R.   +9 more
europepmc   +1 more source

Tangeretin Targets Macrophage M1 Polarization to Alleviate Liver Injury in a Murine Model of Hepatic Sinusoidal Obstruction Syndrome

Phytotherapy Research, EarlyView.
Tangeretin (TAN) alleviates monocrotaline‐induced hepatic sinusoidal obstruction syndrome in mice. By attenuating the Keap1–Nrf2 interaction, TAN promotes Nrf2 nuclear translocation and mitophagy, thereby preserving mitochondrial homeostasis and reducing mitochondrial reactive oxygen species.
Fumin Zhang, Cheng Zhu, Xingyu Li, Tianyin Sun, Yongkang Zhang, Mengwei Wu, Qianqian Zhang, Ying Dai, Xuecan Mei, Derun Kong   +9 more
wiley   +1 more source

Ganoderic Acids Alleviate Dexamethasone‐Induced Muscle Atrophy Potentially via Regulating Protein Synthesis/Degradation, Attenuating Oxidative Stress, and Antagonizing Glucocorticoid Receptor

Phytotherapy Research, EarlyView.
This work proposes a mechanism in which ganoderic acid A (GAA), the active monomer of ganoderic acids (GA) from Ganoderma lucidum, binds to the glucocorticoid receptor (GR) to form a GR‐GAA complex, thereby inhibiting DEX‐induced GR activation. This inhibition suppresses oxidative stress (ROS, MDA and 4‐HNE) by upregulating antioxidant proteins (Nrf2 ...
Kecheng Tang, Yan Yu, Yiru Chen, Zhizhen Huang, Hang Zhang, Yun Tian, Min Li, Yue Yin, Shaowei Li, Bingchuan Liu, Baoxue Yang   +10 more
wiley   +1 more source

Deep population structure linked to host vernalization requirement in the barley net blotch fungal pathogen. [PDF]

Microb Genom
Ramírez Martínez J, Guillou S, Le Prieur S, Di Vittorio P, Bonal F, Taliadoros D, Gueret E, Fournier E, Stukenbrock EH, Valade R, Gladieux P.   +10 more
europepmc   +1 more source

Protective Effect of Epigallocatechin‐3‐Gallate Against Fructose‐Induced Metabolic Associated Fatty Liver Disease in Mice by Regulating Ferroptosis and Autophagy via SIRT5

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD) lacks effective pharmacological therapies and is strongly associated with excessive fructose consumption. Ferroptosis and autophagy dysregulation are increasingly recognized as key drivers of MAFLD progression.
Puyu Zhang, Cuiping Hou, Jiayi Liu, Bosheng Wang, Wenqi Liu, Xin Yang, Yubing Kang, Zequn Liu, Yalin Zhang, Zhuxi Liu, Yuhong Zhao, Lu Zhao   +11 more
wiley   +1 more source

Genomic evidence of genuine wild versus admixed olive populations evolving in the same natural environments in western Mediterranean Basin. [PDF]

PLoS One
Zunino L, Cubry P, Sarah G, Mournet P, El Bakkali A, Aqbouch L, Sidibé-Bocs S, Costes E, Khadari B.   +8 more
europepmc   +1 more source