Results 191 to 200 of about 14,096,383 (244)

6‐Shogaol Promotes Fatty Acid Oxidation and Osteogenic Differentiation in Aged Bone Marrow Mesenchymal Stem Cells Through Allosteric Regulation of Carnitine Palmitoyltransferase 1A

Phytotherapy Research, EarlyView.
ABSTRACT Age‐related osteoporosis is heavily driven by the senescent decline of bone marrow mesenchymal stem cells (BMSCs), characterized by impaired osteogenic differentiation and excessive lipid accumulation. Defective fatty acid oxidation (FAO) is a critical metabolic hallmark of this pathogenic shift.
Yining Zhao, Jianhang Wang, Yuankun Zhang, Zhuohan Cao, Congcong Xu, Hongming Zhou, Liang Ma, Yongchang Tang   +7 more
wiley   +1 more source

Stomatal penetration: the cornerstone of plant resistance to the fungal pathogen Zymoseptoria tritici. [PDF]

BMC Plant Biol
Battache M, Suarez-Fernandez M, Klooster MV, Cambon F, Sánchez-Vallet A, Lebrun MH, Langin T, Saintenac C.   +7 more
europepmc   +1 more source

Fingered Citron Extract Ameliorates Diabetes‐Related Depression via Targeting SRC‐Mediated Insulin Signaling and Neuroinflammation

Phytotherapy Research, EarlyView.
ABSTRACT Diabetes‐related depression (DD) is a challenging comorbidity characterized by self‐reinforcing interactions between metabolic dysfunction and affective disturbance, while conventional antidepressants and glucose‐lowering drugs often yield suboptimal outcomes with adverse effects.
Shun Guo, Tao Yan, Zhuowen Bai, Yuzheng Han, Mengjie Yang, Yajun Zhang   +5 more
wiley   +1 more source

Magnoflorine Ameliorates MASH in Mice Fed a High‐Fat and High‐Fructose Diet by Promoting AMPK‐Mediated Lipophagy and Fatty Acid Oxidation

Phytotherapy Research, EarlyView.
Magnoflorine ameliorates metabolic dysfunction‐associated steatohepatitis by promoting AMPKα‐mediated lipophagy and fatty acid oxidation. ABSTRACT Emerging as a significant clinical burden, metabolic dysfunction‐associated steatohepatitis (MASH) continues to challenge global healthcare systems due to limited effective interventions.
Zhengjie Lu, Tongyun Mao, Longxin Chai, Kaiqi Chen, Kexin Liu, Cong Zhang, Hao Kou   +6 more
wiley   +1 more source

Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack. [PDF]

New Phytol
Morales de Los Ríos L, Pham TD, Perez T, Ben Amar M, Corratgé-Faillie C, Barbier F, Lacombe B.   +6 more
europepmc   +1 more source

Butin Ameliorates Atherosclerosis by Regulating the TIMM13‐TIMM8A Complex to Alleviate Macrophage Ferroptosis

Phytotherapy Research, EarlyView.
The natural flavonoid Butin selectively targets the mitochondrial translocase subunit TIMM13 at residue Asn34, competitively disrupting the pathological TIMM13‐TIMM8A complex. This targeted engagement halts mitochondrial iron influx, reactivates the SLC7A11/GPX4 antioxidant cascade, and attenuates macrophage ferroptosis and foam cell formation ...
Dashuai Wang, Xinyi Yu, Mingjie Xie, Gongcheng Huang, Zhenxing Liang, Chen Huang, Hai Liu   +6 more
wiley   +1 more source

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Reinventing henna: Enzyme-catalysed colour release from stabilized Lawsonia inermis L. extracts. [PDF]

Int J Cosmet Sci
Dallmann N, Vill V, Straske F.
europepmc   +1 more source

Thioredoxin 1 moonlights as a chaperone for an interbacterial ADP-ribosyltransferase toxin. [PDF]

Nat Commun
Dumont B, Terradot L, Cascales E, Van Melderen L, Jurėnas D.   +4 more
europepmc   +1 more source