Results 71 to 80 of about 17,061,900 (337)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
THE QUEST FOR RECOGNITION: THE CASE OF LATIN AMERICAN PHILOSOPHY [PDF]
, 2019 Latin American philosophy has long been concerned with its philosophical identity. In this paper I argue that the search for Latin American philosophical identity is motivated by a desire for recognition that largely hinges on its relationship to ...
RIVERA BERRUZ, Stephanie
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
\u3ci\u3eAmEx\u3c/i\u3e and Post-Cartesian Antitrust [PDF]
, 2019 I. Introduction II. Situating American Express ... A. Different Sides of the American Express Opinion ... 1. Two-Sided Markets ... 2. The American Express Opinion ... B. The Real Issue Is Messy, Not Two-Sided, Markets … C.
Hurwitz, Justin (Gus)
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
American Journal of Respiratory and Critical Care Medicine, 2019 Background: This document provides evidence-based clinical practice guidelines on the management of adult patients with community-acquired pneumonia. Methods: A multidisciplinary panel conducted pragmatic systematic reviews of the relevant research and ...
J. Metlay +14 more
semanticscholar +1 more source
, 2010 Not only are there strong cultural connections between Northern Ireland and North America, but much of the geology of Northern Ireland is related to its shared history with the eastern seaboard of Canada and the USA.
Earls, Garth, Young, Michael
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
SALT Equalizer, Vol. 2016, Issue 1
, 2016 Contents of This Issue: Survey Information and Methodology, at 1. 2015-16 SALT Salary Survey, at 1. About SALT and SALT Membership, at 3. Survey Instrument, at 4.
Society of American Law Teachers
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Children\u27s Books as Cultural Products: A Qualitative Study of Cultural Representation in Hmong and Non-Hmong American Books [PDF]
, 2019 This study examined the type of cultural practices and values depicted within Hmong American children’s books in comparison to non-Hmong American children’s books from the United States. The purpose was to explore if prior Hmong traditional practices and
Her, Malina
core +1 more source