Results 21 to 30 of about 7,717 (249)
Conventionality Standards for Children in Conflict Zones: Colombian Case study
Opinión Jurídica, 2018 The main objective of this paper is to identify the multilevel perspective of hu-man rights protection for children in armed conflicts. For that, the pro persona or pro homine principle may be applied.
Luiz Guilherme Arcaro Conci +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Sanctioning Chile’s Public Health Care System for Not Providing Basic Services to the Elderly: The Inter-American Court’s Poblete Vilches Ruling [PDF]
Health and Human Rights, 2020 This paper analyzes the Inter-American Court of Human Rights’ ruling in the case of Poblete Vilches et al. v. Chile. Poblete Vilches, a senior citizen, died in February 2001 due to septic shock and bilateral bronchopneumonia after being treated in a ...
Ángela Arenas Massa +2 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Conservative Governments and Latin America's Human Rights Landscape
AJIL Unbound, 2019 In 2009, as the American Convention on Human Rights turned forty, Left-wing governments ruled in almost all Latin American countries. The democratization wave that began in the late 1980s had produced a seemingly hegemonic turn to the Left—the so-called “
Jorge Contesse
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The Convention of Belém do Pará a report of its application in the jurisprudence of the Inter-American Court, 16 years after its entry into force [PDF]
Civilizar, 2011 This article is presented as a result of an investigation that had the object to know the cases which the Inter-American Court of human Rights applied “The Inter-American Convention on the prevention, punishment and eradication of violence against women “
Diana Marcela Bustamante Arango +1 more
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International mechanisms for the protection of the right to life in armed conflicts
Проблеми Законності, 2018 The article is devoted to the actual topic of international mechanisms for the protection of the right to life in international and non-international armed conflicts.
Iurii Usmanov
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source