Results 31 to 40 of about 5,975 (169)

Canine Leishmaniasis in Rio de Janeiro, Brazil (2000–2015): Taxonomic Characterisation of Etiological Agents and Geospatial Case Analysis

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Canine Leishmaniasis is a vector‐borne zoonotic disease caused by several species of protozoa of the genus Leishmania. In the state of Rio de Janeiro (RJ), Leishmania braziliensis is the most prevalent species causing tegumentary leishmaniasis (TL) and Leishmania infantum is the main causative agent of visceral leishmaniasis (VL).
Luciana de Freitas Campos Miranda, Laryssa Fabiano do Rosário Coelho, Samanta Cristina das Chagas Xavier, Artur Augusto Velho Mendes Junior, Renan Nunes Albuquerque, Aline Fagundes da Silva, Andreza Pain Marcelino, Fernanda Nunes Santos, Sandro Antonio Pereira, Rodrigo Caldas Menezes, Armando de Oliveira Schubach   +10 more
wiley   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1087-1097, April 2026.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Leishmaniose tegumentar americana: apresentação pouco comum American tegumentary leishmaniasis: an unusual presentation

Anais Brasileiros de Dermatologia, 2008
Relata-se caso de leishmaniose tegumentar americana com lesões proeminentes na face. Os critérios diagnósticos incluíram dados clínicos e epidemiológicos, intradermorreação de Montenegro, identificação de Leishmania pela reação em cadeia da polimerase e ...
Antonio Carlos Martins Guedes, Maria de Lourdes R. de Carvalho, Maria Norma Melo   +2 more
doaj   +1 more source

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

Defensive medicine in dermatological practice – Dermatopathology as a mirror of structural challenges

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 3, Page 302-315, March 2026.
Summary Defensive medicine refers to diagnostic or therapeutic actions taken primarily to reduce legal liability rather than to benefit the patient. In dermatopathology, defensive practices manifest in frequent immunohistochemical testing, overly cautious report phrasing, and reliance on multidisciplinary tumor boards.
Cornelia Sigrid Lissi Müller, Torsten Hansen, Claus Renzelmann   +2 more
wiley   +1 more source

Cutaneous parasitism in patients with American visceral leishmaniasis in an endemic area

Revista da Sociedade Brasileira de Medicina Tropical, 2020
INTRODUCTION: Visceral leishmaniasis (VL) represents a public health concern in several areas of the world. In the American continent, VL transmission is typically zoonotic, but humans with active VL caused by Leishmania infantum are able to infect ...
Carla Riama Lopes de Pádua Moura, Carlos Henrique Nery Costa, Rafael de Deus Moura, Aline Reis Ferro Braga, Vladimir Costa Silva, Dorcas Lamounier Costa   +5 more
doaj   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

American cutaneous leishmaniasis: use of a skin test as a predictor of relapse after treatment

Bulletin of the World Health Organization, 2000
While relapses following clinical cure of American cutaneous leishmaniasis are frequent, no test has been described until now to predict such relapses.
Valéria M.A. Passos, Sandhi M. Barreto, Alvaro J. Romanha, Antoniana U. Krettli, Ângela C. Volpini, Maria Fernanda F. Lima e Costa   +5 more
doaj  

American cutaneous leishmaniasis in a northeast Brazilian city: clinical and epidemiological features

Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION This study characterized the clinico-epidemiological profile of American cutaneous leishmaniasis (ACL) cases in Barbalha, Ceará State, Brazil.
Cícero Roberto Pinheiro Grangeiro Júnior, João Vitor Cândido Pimentel, Antonio Gilvan Teixeira Júnior, Aline Felipe de Jesus, Thaila Cristhina Fernandes Galvão, Lorenza Andrés Almeida de Souza, Maria do Socorro Vieira Gadelha, Kécia Silva Damasceno, Modesto Leite Rolim Neto, Marcos Antonio Pereira de Lima, Vânia Barbosa do Nascimento, Cláudio Gleidiston Lima da Silva   +11 more
doaj   +1 more source

Analysis of the specificity of human antibodies to antigens of Leishmania braziliensis braziliensis

Revista do Instituto de Medicina Tropical de São Paulo, 1989
The antigenicity of promastigotes of Leishmania braziliensis braziliensis (L. b.braziliensis) treated with 1% sodium desoxycholate in 10 mM Tris-Hcl pH 8.2 was analysed by immunoblot using as probes sera from American cutaneous leishmaniasis (ACL ...
Aoi Masuda, Sueli Fátima do Nascimento, Carmem Silvia Guerra, Gláucia da Silva Paranhos, Antonio Walter Ferreira   +4 more
doaj   +1 more source