Results 41 to 50 of about 1,134,311 (312)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The American Psycho(sis) goes Suburbia. Madness, Depravity, and Gender in Domestic Topographies
Investigaciones Feministas, 2013 While the home had always been an important concept in American culture, the suburban home was unique. Unlike the urban neighborhood, the suburban home or the rural farm were founded on their separation from both the world of work and from the world of ...
Dorota Wisnieswska
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Faulkner's Southern belle - myth or reality?
Acta Neophilologica, 2011 The article deals with heroines of William Faulkner's novels Light in August, Absalom, Absalom!, The Sound and the Fury, The Unvanquished, The Town and his short story "A Rose for Emily". The Southern belle features as a recurring character in Faulkner's
Nataša Intihar Klančar
doaj +1 more source
It is More than a Bunch of Numbers: Trauma, Voicing and Identity in Jennifer Chow’s The 228 Legacy
Res Rhetorica, 2020 This paper explores how Jennifer Chow’s The 228 Legacy (2013) recaptures the buried hi/stories of the 228 Massacre with a trauma narrative about Silk’s deep-kept secrets.
Pi-hua Ni
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Airborne Toxicity in Don DeLillo’s White Noise
Open Cultural StudiesIn the wake of the COVID-19 pandemic, people across the world came to realize the significant relationship between air and human health. This pandemic, which changed the course of many lives, demonstrated how air serves as a transmitter of viruses ...
Ömerali Uslu Mine
doaj +1 more source
Looking for Kunta Kinte: Alex Haley's Roots and African American Genealogies
Iperstoria, 2014 As the 30th anniversary 2006 edition recalls, Alex Haley’s Roots: The Saga of an American Family was a big popular success: in 1976, the year it was published, “the book sold over one million copies” and in 1977 the miniseries created out of it “was ...
Elisa Bordin
doaj +1 more source