Results 31 to 40 of about 618,010 (298)

Protein structure validation and refinement using amide proton chemical shifts derived from quantum mechanics [PDF]

, 2013
We present the ProCS method for the rapid and accurate prediction of protein backbone amide proton chemical shifts - sensitive probes of the geometry of key hydrogen bonds that determine protein structure.
Boomsma, Wouter, Borg, Mikael, Christensen, Anders S., Hamelryck, Thomas, Jensen, Jan H., Lindorff-Larsen, Kresten, Linnet, Troels E.   +6 more
core   +4 more sources

Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain

Frontiers in Pharmacology, 2022
A prodrug approach is a powerful method to temporarily change the physicochemical and thus, pharmacokinetic properties of drugs. However, in site-selective targeted prodrug delivery, tissue or cell-specific bioconverting enzyme is needed to be utilized ...
Agathe Hugele, Susanne Löffler, Belén Hernández Molina, Melina Guillon, Ahmed B. Montaser, Seppo Auriola, Kristiina M. Huttunen   +6 more
doaj   +1 more source

Gestão Educacional em Moçambique: desafios versus Soluções - estudo de caso no distrito de Lichinga

Revista de Estudos em Educação e Diversidade
O presente artigo tem como objectivo compreender os desafios e estratégias da gestão educacional em três escolas do distrito de Lichinga, em Moçambique, analisando como as práticas de liderança e administração escolar podem contribuir para a melhoria da
Edigar Wilson Magalhaes, João Baptista Amide   +1 more
doaj   +1 more source

N-(2-(1H-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide

Molbank, 2020
N-(2-(1H-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide was prepared by a reaction between tryptamine and flurbiprofen, applying N,N’-Dicyclohexylcarbodiimide, as a coupling agent.
Stanimir Manolov, Iliyan Ivanov, Dimitar Bojilov   +2 more
doaj   +1 more source

Biologically Active Compounds. II. The Synthesis of　β-CarboxY-γ-butyrolactone Derivatives [PDF]

, 1968
Amide derivatives of γ-substituted paraconic and aconic　acids have been　synthesized. Ultraviolet spectra of the aconic acid derivatives showed characteristic　fine structure in the region of 245 to 280 ...
Isikawa, Tatsuo, Takeda, Akira, Torii, Sigeru   +2 more
core   +1 more source

Transition-Metal-Free Activation of Amide Bond by Arynes

Molecules, 2018
Highly reactive arynes activate the N–C and C=O bonds of amide groups under transition metal-free conditions. This review highlights the insertion of arynes into the N–C and C=O bonds of the amide group.
Hideto Miyabe
doaj   +1 more source

N-(Benzo[d]thiazol-2-yl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide

Molbank, 2021
N-(Benzo[d]thiazol-2-yl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide was prepared by a reaction between benzo[d]thiazol-2-amine and flurbiprofen in high yield.
Stanimir Manolov, Iliyan Ivanov, Dimitar Bojilov   +2 more
doaj   +1 more source

N-[2-(1H-Indol-3-yl)ethyl]-2-(4-isobutylphenyl)propanamide

Molbank, 2018
The compound in the title was prepared by reaction between tryptamine and ibuprofen using N,N′-dicyclohexylcarbodiimide as a “dehydrating„ reagent.
Stanimir Manolov, Iliyan Ivanov, Yulian Voynikov   +2 more
doaj   +1 more source

New Amides and Phosphoramidates Containing Selenium: Studies on Their Cytotoxicity and Antioxidant Activities in Breast Cancer

Antioxidants, 2021
Breast cancer is a multifactor disease, and many drug combination therapies are applied for its treatment. Selenium derivatives represent a promising potential anti-breast cancer treatment.
Mikel Etxebeste-Mitxeltorena, Daniel Plano, Nora Astrain-Redín, Cristina Morán-Serradilla, Carlos Aydillo, Ignacio Encío, Esther Moreno, Socorro Espuelas, Carmen Sanmartín   +8 more
doaj   +1 more source

Solid-state conformation of copolymers of ß-benzyl-L-aspartate with L-alanine, L-leucine, L-valine, γ-benzyl-L-glutamate, or ε-carbobenzoxy-L-lysine [PDF]

, 1980
The solid-state conformation of copolymers of ß-benzyl-L-aspartate [L-Asp(OBzl)] with L-leucine (L-Leu), L-alanine (L-Ala), L-valine (L-Val), γ-benzyl-L-glutamate [L-Glu(OBzl)], or ε-carbobenzoxy-L-lysine (Cbz-L-Lys) has been studied by ir spectroscopy ...
Anderson, James M., Bantjes, Adriaan, Feijen, Jan, Sederel, Willem L.   +3 more
core   +2 more sources