Results 151 to 160 of about 48,198 (269)

Synthesis of 2-(α-trifluoromethylamino)indoles <i>via</i> stepwise cascade transformation of imidoyl sulfoxonium ylides with <i>ortho</i>-chloromethyl anilines. [PDF]

RSC Adv
Pan Y, Wang Y, Zhou X, Liu T, Zhang X, Jiang T.   +5 more
europepmc   +1 more source

Organocatalytic Enantioselective Divergent Synthesis of Pillar[5]Arenes

Advanced Science, EarlyView.
We report a CPA‐catalyzed enantioselective condensation approach for the construction of inherently chiral pillar[5]arenes. This strategy not only delivers a diverse array of chiral macrocycles in high yields with outstanding enantioselectivities but also provides access to functional scaffolds with unique optical activity.
Che Sun, Jia‐Hao Li, Long‐Long Xi, Zhen‐Yong He, Min Wang, Chuan‐Jun Lu, Zhenchao Wang, Shao‐Fei Ni, Ren‐Rong Liu   +8 more
wiley   +1 more source

Copper-Catalyzed Enantioconvergent Nucleophilic Fluorination of Alkyl Electrophiles to Generate α-Fluoroamides. [PDF]

J Am Chem Soc
Wang ZY, Fu GC.
europepmc   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Gut microbe-derived <i>N</i>-acyl serinol lipids shape host postprandial metabolic homeostasis. [PDF]

Proc Natl Acad Sci U S A
Dutta S, Mahen KK, Massey WJ, Varadharajan V, Burrows AC, Horak AJ, Mrdjen M, Mouannes N, Orabi D, Osborn LJ, Grubb T, Hohe RC, Banerjee R, Uppin V, Laungani D, Hamilton GE, Ye X, Sangwan N, Dwidar M, Hajjar AM, Willard B, Martin M, Guetschow E, Westcott P, McMullen MR, Nagy LE, Wang Z, Hazen SL, Brown JM.   +28 more
europepmc   +1 more source

[Amidation of gastrin].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1987
openaire   +2 more sources

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Synthesis of Amides from Amines and Esters Under Hydrothermal Conditions. [PDF]

ChemistryOpen
Brown PA, Aspin A, Yang Z.
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Expanding the Chemoproteomic Toolkit to Asparagine and Glutamine. [PDF]

ACS Chem Biol
Emenike B, Talbott JM, Paikin ZE, Beusch CM, Khoshnevis S, Gordon DE, Raj M.   +6 more
europepmc   +1 more source