Results 221 to 230 of about 173,620 (335)

Derogation Effect of Arbitration Clause Address at the Workshop Conference “International Commercial Arbitration in Russia Amid Economic Development Globalization”, Devoted to the 15th Anniversary of the Russian Law on International Commercial Arbitration and the Semi-Centenary of the UN Convention on the Recognition and Enforcement of Foreign Arbitral Awards (i.e. the New York Convention), October 17, 2008

, 2008
Ю. Э. Монастырский
openalex   +2 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Palladium-Catalyzed Carbonylative Fluoroalkylation of 1,3-Enynes to Access Allenyl Primary Amides. [PDF]

Org Lett
Kuai CS, A RH, Bao ZP, Wu XF.
europepmc   +1 more source

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source

Aldehydes as CO Releasing Molecules: <i>In Situ</i> and <i>Ex Situ</i> Giese Reactions and Palladium-Catalyzed Aminocarbonylations. [PDF]

Org Lett
Cassera E, Fagnoni M.
europepmc   +1 more source

Synthesis and multimodal activity of 3a,6-epoxyisoindole-2(3H)-(carbox/thio/seleno)amides in models of glycation, oxidative stress, and inflammation: Toward the development of agents targeting the triggering mechanisms of fibrogenesis

U.M. Ibragimova, N. V. Valuysky, V. R. Rayberg, S A Sorokina, K. I. Zhukova, D. K. Deryagin, I. S. Ukhorenko, A.A. Grigoryeva, D. M. Shchevnikov, V.P. Zaytsev, R.A. Litvinov   +10 more
openalex   +2 more sources

A Biomimetic Buffering Hydrogel Scaffold for Long‐Term Culture of Patient‐Derived Tumor Organoids

Advanced Healthcare Materials, EarlyView.
A biomimetic fibrous buffering hydrogel controls the local acidification at the tumoroid/hydrogel interface at the physiologically relevant level over 21‐day culture. The buffering effect promotes cancer cell proliferation in the tumoroids and supports the structural integrity and mechanical properties of the hydrogel scaffold over long‐term tumoroid ...
Elizaveta Gusarova, Fatemeh Ahmadi, Jennifer Cruickshank, Zheyuan Miao, David W. Cescon, Eugenia Kumacheva   +5 more
wiley   +1 more source

Enantioselective [2,3]-Wittig rearrangement of allyl picolyl ethers with chiral lithium amides. [PDF]

RSC Adv
Kawasaki M, Yatsuzuka K, Shirai R.
europepmc   +1 more source

Bi‐Functional Topospecific Nanoparticles to Promote Immune‐Tumor Cell Engagement as A New Immunotherapeutic Strategy

Advanced Materials, EarlyView.
A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Alba Ortuño‐Bernal, Sandra Clara‐Trujillo, Elena Lucena‐Sánchez, Francisco J. Hicke, Andrea Escudero, Sandra Pradana‐López, Nelia Jiménez‐Alduan, Paula Díez, Alba García‐Fernández, Ramón Martínez‐Máñez   +9 more
wiley   +1 more source