Results 221 to 230 of about 79,537 (266)

Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform

Advanced Science, EarlyView.
Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao, Cang‐Man Zhang, Ru‐Jie Yang, Min Ren, Zhuo‐Ling Zhong, Kang‐Hui Wang, Rui‐Xue Hu, Jia‐Yue Liu, Jun‐Yi Zhou, Hou‐Kai Li, Jian‐Bo Wan   +10 more
wiley   +1 more source

C₁-Symmetric Salan-Zr(IV) Catalyst for Efficient and Highly Enantioselective α-Hydroxylation of β-Keto Esters and Amides. [PDF]

Chem Asian J
Ma C, Tang K, Zhao J, Wu Y, Wang Y, Li J, Liu Q, Meng Q.   +7 more
europepmc   +1 more source

Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform Toward Non‐Invasive Diagnostics

Advanced Science, EarlyView.
Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform toward Non‐Invasive Diagnostics is a nature‐inspired strategy that engineers controlled randomness within block copolymer lamellae to achieve optical isotropy without compromising nanoscale periodicity.
Jin Man Kim, Wonsik Kim, Wansun Kim, Yeon‐Hee Kim, Samjin Choi, Jang Hwan Kim, Hyeong Min Jin   +6 more
wiley   +1 more source

Mechanochemical Methods for Amide Bond Formation. [PDF]

Chem Rev
Nikonovich T, Chatzigiannis CM, Bordier C, Solorzano-Rodriguez R, Baier DM, Ort FF, Aav R, Leyssens T, Blanco-Ania D, Rutjes FPJT, Kananovich D, Colacino E.   +11 more
europepmc   +1 more source

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

General and selective ruthenium-catalyzed hydrogenation of primary amides to primary amines under mild conditions. [PDF]

Nat Commun
Kuloor C, Goyal V, Ma Z, Poovan F, Peña Fuentes D, Baumann W, Zhao J, Zbořil R, Beller M, Jagadeesh RV.   +9 more
europepmc   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late-Stage Modification of Drugs. [PDF]

Adv Sci (Weinh)
Mou XQ, Zha X, Jian YR, Zhong SX, Fu XY, Xu SY, Xiang W, Cui BD, Zhang Y, Chen YZ.   +9 more
europepmc   +1 more source

Radical‐Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads

Advanced Science, EarlyView.
A radical‐mediated in situ fluorescence dye deposition (RIFD) reaction containing merely three elements of beads, dyes, and radicals is discovered for the first time, and its underlying mechanism is elucidated. This simple RIFD enables the interfacial and ultrafast deposition of free dyes onto barcode beads, serving as a powerful signal amplification ...
Jiayu Zhang, Yao Wang, Xinyi Huang, Haiyu Wu, Qiuning Lin, Hongchen Gu, Li Jiang, Linyong Zhu, Hong Xu   +8 more
wiley   +1 more source

Soybean oil fatty acid aromatic amides as dual-functional inhibitors and antimicrobial agents: synthesis, characterization, thermal stability, and performance evaluation. [PDF]

BMC Chem
Dadashova NK, Abbasov VM, Aghamaliyeva DB, Aghamaliyeva DB, Mursalov NI, Talybov AH, Alieva NM, Mammadov AM, Alqahtani T, Zerihun YA, Zaki MEA, Ahmadbayova SF.   +11 more
europepmc   +1 more source