Results 21 to 30 of about 48,198 (269)

Probing Reactivity with External Forces: The Case of Nitroacetamides in Water

Molecules, 2023
Many computational methods have been applied to interpret and predict changes in reactivity by slight modifications of a given molecular scaffold. We describe a novel and simple method based on approximate density-functional theory of valence electrons ...
Giovanni La Penna, Fabrizio Machetti
doaj   +1 more source

Enantioselective synthesis of γ-chiral amides via copper-catalyzed reductive relay hydroaminocarbonylation

Nature Communications
Chiral amides are common and effective structural motifs found in many pharmaceuticals and biologically active molecules. Despite their importance, existing synthetic methods are predominantly employed for the synthesis of α-amides and β-amides.
Yang Yuan, Youcan Zhang, Xiao-Feng Wu
doaj   +1 more source

Multi-environment evaluations across ecological regions reveal climate and soil effects on amides contents in Chinese prickly ash peels (Zanthoxylum bungeanum Maxim.)

BMC Plant Biology, 2023
Background Environmental factors difference is the key factor for the difference in the production, transformation and accumulation of effective components in plants.
Tao Zheng, Hai-tao Zeng, Bing-yin Sun, Shu-ming Liu   +3 more
doaj   +1 more source

Ruthenium-Catalyzed Oxidative Amidation of Alkynes to Amides [PDF]

Organic Letters, 2019
Complex CpRuCl(PPh3)2 catalyzes reactions of terminal alkynes with 4-picoline N-oxide and primary and secondary amines to afford the corresponding amides. The reactions occur in chlorinated solvent and aqueous medium, showing applications in peptide chemistry.
Andrea Álvarez-Pérez, Miguel A. Esteruelas, Susana Izquierdo, Jesús A. Varela, Carlos Saá   +4 more
openaire   +5 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Ammonothermal Synthesis and Crystal Structures of Diamminetriamidodizinc Chloride [Zn2(NH3)2(NH2)3]Cl and Diamminemonoamidozinc Bromide [Zn(NH3)2(NH2)]Br

Inorganics, 2016
The treatment of excess zinc in the presence of ammonium chloride under ammonothermal conditions of 873 K and 97 MPa leads to diamminetriamidodizinc chloride [Zn2(NH3)2(NH2)3]Cl with a two-dimensionally μ-amido-interconnected substructure.
Theresia M. M. Richter, Sabine Strobel, Nicolas S. A. Alt, Eberhard Schlücker, Rainer Niewa   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Synthesis and anion recognition properties of shape-persistent binaphthyl-containing chiral macrocyclic amides

Beilstein Journal of Organic Chemistry, 2012
We report on the synthesis and characterization of novel shape-persistent, optically active arylamide macrocycles, which can be obtained using a one-pot methodology.
Marco Caricato, Nerea Jordana Leza, Claudia Gargiulli, Giuseppe Gattuso, Daniele Dondi, Dario Pasini   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source