Results 131 to 140 of about 16,803 (187)
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Amiloride‐Induced Hyponatremia
Acta Medica Scandinavica, 1980ABSTRACT. We present three aged female patients who fulfil the criteria of a syndrome that we call “amiloride hyponatremia”. They became hypona‐tremic during amiloride + hydrochlorothiazide therapy. They needed diuretic therapy and tolerated well hydrochlorothiazide with potassium supplementation as potassium chloride.
L, Tarssanen, M, Huikko, M, Rossi
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Amiloride and the sodium channel
Naunyn-Schmiedeberg's Archives of Pharmacology, 1974Amiloride and the sodium channel. The diuretic drugs amiloride and triamterene have been used as probes for sodium channels in the mucosal surface of isolated frog skin. Both substances interact competitively with sodium for the channel. Using 14C-amiloride measurements were made of the number of channels present in the mucosal surface under a variety ...
A W, Cuthbert, W K, Shum
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Amiloride pharmacokinetics in rat
European Journal of Drug Metabolism and Pharmacokinetics, 1998The kinetics of amiloride was investigated in plasma, urine, faeces and tissues of rats after oral (10 mg/kg) and i.v. (10 mg/kg bolus and 35 microg/h for 4-days infusion) administration. Initially the experimental data were analyzed by a multiexponential model, then a compartmental model was developed to describe the drug kinetics in plasma, urine ...
G, Segre +4 more
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Amiloride in Bartter's syndrome
Clinical Pharmacology and Therapeutics, 1982Hypokalemia in Bartter's syndrome (BS) is often difficult to correct despite all measures. Amiloride is a new potassium-sparing diuretic that blocks sodium channels in distal renal tubular cells, independent of aldosterone. Four patients with BS were studied, in an outpatient clinic, while on amiloride therapy (10 to 40 mg/day).
G T, Griffing +4 more
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Distinct epitopes on amiloride
American Journal of Physiology-Cell Physiology, 1989Most Na(+)-selective transport proteins are inhibited by the drug amiloride. Studies using amiloride analogues suggest that specific regions of amiloride might participate in binding to receptors on these transport proteins. To determine whether certain domains of this drug are recognized as distinct epitopes, amiloride was coupled to albumin through ...
T R, Kleyman +4 more
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Amiloride in primary hyperaldosteronism
Clinical Pharmacology and Therapeutics, 1982Amiloride is a potassium-sparing diuretic used in spontaneous and diuretic-induced hypokalemia. The effect of amiloride was studied prospectively in 12 patients with primary hyperaldosteronism. Four patients had unilateral adrenal adenomas and eight had bilateral adrenal hyperplasia. All patients were hypertensive and their mean plasma potassium levels
G T, Griffing +5 more
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Modulation of cardiac performance by amiloride and several selected derivatives of amiloride.
The Journal of Pharmacology and Experimental Therapeutics, 1993Amiloride and its derivatives (benzamil, dichlorobenzamil, 5-(N,N-dimethyl)-amiloride, 5-(N-ethyl-N-isopropyl)-amiloride, (N,N-hexamethylene)- amiloride and 5-(N-methyl-N-isobutyl)-amiloride) are commonly used as selective blockers of Na+/Ca++ exchange or Na+/H+ exchange. Very little information is currently available regarding their effects on cardiac
Pierce, G. +8 more
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New amiloride analogue as hapten to raise anti-amiloride antibodies
American Journal of Physiology-Cell Physiology, 1986A new amiloride analogue, "amiloride-caproic acid," was synthesized, coupled to albumin, and used as a hapten to raise anti-amiloride antibodies in rabbits. The antibodies were affinity purified with an amiloride affinity column and characterized. Binding studies using [3H]benzamil showed a dissociation constant of 0.8 nM.
T R, Kleyman +4 more
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