Results 221 to 230 of about 447,214 (305)

Root‐Inspired Microneedle Patch With Interlocked Rigid‐Soft Architecture for High Tissue‐Adaptiveness

Advanced Science, EarlyView.
A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Jongchan Lee, Yeongjun Song, Yonghyun Cho, Hyo In Kim, Dong‐Hyun Youn, Jinbong Park, Seungbeom Choi, Dohyun Kwon, Brian Jun Lee, Sangyul Baik   +9 more
wiley   +1 more source

Unusual Chemodivergence in the Amination of 2-Chloro-1,10-Phenanthroline with Di- and Polyamines: Comparison of the Pd-Catalyzed and Catalyst-Free Pathways. [PDF]

Molecules
Ionova VA, Gontcharenko VE, Viderskii KS, Averin AD, Abel AS, Beletskaya IP.   +5 more
europepmc   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Accelerated Synthesis of Novel Indole-3-Sulfonamides Leveraging High-Throughput Experimentation. [PDF]

ACS Med Chem Lett
Bercher OP, Lupinacci K, Breslin MJ, El Marrouni A.   +3 more
europepmc   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Matrix-dependent bioaccessibility of bioactive amines in Milano dry-fermented sausages after in vitro digestion. [PDF]

Curr Res Food Sci
Braga DE, Dala-Paula BM, Gonçalves JE, Castilho M, Ferreira ES, Gloria MBA.   +5 more
europepmc   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Modified Reaction Conditions for the Radiosynthesis of ¹¹C‑Labeled Asymmetrical Guanidines and the Automated Radiosynthesis of a [¹¹C]<i>m</i>IBG Analog. [PDF]

ACS Med Chem Lett
Witek JA, Allen AC, Brooks AF, Cingoranelli SJ, Stauff J, Kaur T, Shao X, Scott PJH, Raffel DM.   +8 more
europepmc   +1 more source