Results 141 to 150 of about 167,642 (275)

Insights into the genomic divergence of maize heterotic groups in China

Journal of Integrative Plant Biology, EarlyView.
Seven core heterotic groups were differentiated in maize germplasm from China, and these groups showed regionality and uniqueness at the genomic level. The environmental adaptability of heterotic groups was improved by selection for more stress tolerance‐related genes for adaptation to the complex and changeable climate.
Yingjie Xue, Yikun Zhao, Yunlong Zhang, Rui Wang, Xiaohui Li, Zhihao Liu, Weiwei Wang, Shaoxi Zhu, Yaming Fan, Liwen Xu, Wei Zhao, Jiuran Zhao, Fengge Wang   +12 more
wiley   +1 more source

Deep learning assisted SERS detection of prolines and hydroxylated prolines using nitrilotriacetic acid functionalized gold nanopillars [PDF]

arXiv
Proline (Pro) is one kind of proteinogenic amino acid and an important signaling molecule in the process of metabolism. Hydroxyproline (Hyp) is a product on Pro oxygen sensing post-translational modification (PTM), which is efficiently modulated tumor cells for angiogenesis. Distinguishing between Pro and Hyp is crucial for diagnosing connective tissue
arxiv  

Optimality of the genetic code with respect to protein stability and amino acid frequencies [PDF]

Genome Biology 2 (2001) research0049, 2001
How robust is the natural genetic code with respect to mistranslation errors? It has long been known that the genetic code is very efficient in limiting the effect of point mutation. A misread codon will commonly code either for the same amino acid or for a similar one in terms of its biochemical properties, so the structure and function of the coded ...
arxiv  

Newborn screening using tandem mass spectrometry: A systematic review [PDF]

Objectives: To evaluate the evidence for the clinical effectiveness of neonatal screening for phenylketonuria (PKU) and medium-chain acyl-coA dehydrogenase (MCAD) deficiency using tandem mass spectrometry (tandem MS).
Beverley, C., Chilcott, J., Eastham, J., Paisley, S., Pandor, A.   +4 more
core  

Untargeted Metabolomic Analysis of Sjögren–Larsson Syndrome Reveals a Distinctive Pattern of Multiple Disrupted Biochemical Pathways [PDF]

, 2023
Sjögren–Larsson syndrome (SLS) is a rare inherited neurocutaneous disease characterized by ichthyosis, spastic diplegia or tetraplegia, intellectual disability and a distinctive retinopathy.
Dai, Hongying Daisy, Fruttiger, Marcus, Jackson, Kimberly, Qiu, Fang, Rizzo, William B   +4 more
core  

Modulation of lignin and anthocyanin homeostasis by GTP cyclohydrolase1 in maize

Plant Biotechnology Journal, EarlyView.
Summary Maize is a key biomass resource with wide agricultural applications. Anthocyanins, potent antioxidants, offer health benefits like reducing oxidative stress. The biosynthesis of anthocyanins competes with that of lignin for shared metabolic precursors, which can lead to trade‐offs in plant growth and feed quality.
Mingyue Zhang, Xiaohan Li, Xiao Wang, Shuzhen Jiang, Junli Zhang, Mingfei Sun, Zixian Zhou, Jinxiao Zhang, Mengyao Li, Yanxiao Lv, Enlong Qi, Ziang Tian, Hongjie Zhu, Xuebin Zhang, Xiangyu Zhao, Changcheng Xu, Thomas Lübberstedt, Xiansheng Zhang, Xuerong Yang, Chao Zhou, Hongjun Liu   +20 more
wiley   +1 more source

Clinical, biochemical and molecular characteristics of classic homocystinuria in Saudi Arabia and the impact of newborn screening on prevention of the complications: A tertiary center experience

JIMD Reports
Background Classic homocystinuria (HCU) is a rare inborn metabolic disease that is generally asymptomatic at birth. If untreated, it can cause a wide range of complications including intellectual disability, lens dislocation, and thromboembolism.
Ahmed Sarar Mohamed, Talal AlAnzi, Amal Alhashem, Hadeel Alrukban, Fahad Al Harbi, Sarar Mohamed   +5 more
doaj   +1 more source

High-risk screening and diagnosis of inborn errors of metabolism : a practical guide for laboratories [PDF]

, 2018
Inborn errors of metabolism (IEM) are a large and heterogeneous group of genetic diseases. In most of these conditions, the presence of variants in specific genes leads to enzyme deficiencies that affect a particular metabolic step.
Civallero, Gabriel Eduardo Santiago, Giugliani, Roberto, Kremer, Raquel   +2 more
core  

Copper‐Induced Transgenerational Plasticity in Plant Defence Boosts Aphid Fitness

Plant, Cell &Environment, EarlyView.
ABSTRACT Transgenerational plasticity in plants is an increasingly recognized phenomenon, yet it is mostly unclear whether transgenerational plasticity is relevant to both the fitness of the plant and its interacting species. Using monoclonal strains of the giant duckweed (Spirodela polyrhiza) and its native herbivore, the waterlily aphid ...
Alexandra Chávez, Anne Schreyer, Pauline Prüsener, Martin Schäfer, Shuqing Xu, Meret Huber   +5 more
wiley   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source