Results 201 to 210 of about 257,506 (253)

Development of Antagonist Peptides of the Crk/CrkL SH2 Domains by Modifying the Peripheral Amino Acid Residues of the YXXP Motif. [PDF]

Biochemistry
Park T, Roy A, Douglas JT, Harned L, Neuenswander SA, Large N, Mudduluru G, Broward M, Johnson DK.   +8 more
europepmc   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Promoting Effects of Urinary Proteins from Stone Formers and Influence of Their Physicochemical Properties on Calcium Oxalate Kidney Stone Formation. [PDF]

Comput Struct Biotechnol J
Suttapitugsakul S, Peerapen P, Thongboonkerd V.   +2 more
europepmc   +1 more source

Genome-Wide Identification of the Phosphoglycerate Kinases and Functional Analysis of <i>GmPGK5</i> in Regulating Oil Accumulation in Soybean. [PDF]

Plants (Basel)
Zhang K, Zhu F, Yue X, Yang S, Mo Y, Zhao S, Gai J, Li Y.   +7 more
europepmc   +1 more source

Genome-wide analysis of the AP2/ERF gene family in Rheum officinale Baill.: Evolution and expression profiling during plant development, abiotic stresses, and exogenous hormone responses. [PDF]

Plant Genome
Tang J, Cui GC, Pan H, Lu H, Li YM, Yan F, Gao J, Peng L, Hu XC, Zhang G.   +9 more
europepmc   +1 more source

Morphological and compositional basis of silk fiber function in <i>Actias luna</i>.

J Mater Chem B
Eccles LE, Foquet B, Markee A, Liwang RK, Basso KB, Kawahara AY, Stoppel WL.   +6 more
europepmc   +1 more source

Molecular evolution and diversity of the norovirus RNA-dependent RNA polymerase. [PDF]

Sci Rep
Flint A, Jawad M, Nasheri N.
europepmc   +1 more source

A novel hexasegmented virus isolated from the phytopathogenic fungus Verticillium nonalfalfae. [PDF]

Arch Virol
Miljanić V, Sabanadzovic S, Aboughanem-Sabanadzovic N, Jakše J, Radišek S, Štajner N.   +5 more
europepmc   +1 more source

Phenotypic and molecular analysis of seabuckthorn accessions reveal promising genotypes and candidate genes associated with micronutrients. [PDF]

BMC Plant Biol
Hakeem S, Saddique MAB, Wiehle M, Ali Z.
europepmc   +1 more source