Results 251 to 260 of about 405,820 (287)

Harnessing D‐amino acids for peptide motif designs

International Journal of Peptide and Protein Research, 1994
In examining the use of d‐amino acids in designing specific peptide folding motifs, the tetrapeptide Boc‐d‐Glu‐Ala‐Gly‐Lys‐NHMe 1 and its analog 2 featuring l‐Glu were synthesized for a comparison of their solution conformations by NMR spectroscopy. The temperature coefficients of amide proton resonances, NOE data, side‐chain CH2 anisotropies and salt ...
VIVEK BOBDE, Y.U. SASIDHAR, SUSHEEL DURANI   +2 more
openaire   +1 more source

Conservation of amino-acid sequence motifs in lentivirus Vif proteins

Virus Genes, 1992
The nonstructural/regulatory genes of human immunodeficiency virus type 1 (HIV-1) and other lentiviruses are believed to play an important role in the replication and pathogenesis of these viruses. In HIV-1 and other lentiviruses, the vif (viral infectivity factor) open reading frame (ORF) (also termed sor or Q in some lentivirus genomes) is located in
M S, Oberste, M A, Gonda
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Catalysis with Phosphine-Containing Amino Acids in Various “Turn” Motifs

The Journal of Organic Chemistry, 2004
We have been actively involved in the development of parallel approaches for the discovery of phosphine ligands. Our approach has been based on the incorporation of phosphine-containing amino acids into peptide sequences that are designed to have stable secondary structures.
Anton, Agarkov, Scott J, Greenfield, Takahiro, Ohishi, Scott E, Collibee, Scott R, Gilbertson   +4 more
openaire   +2 more sources

Ned Seeman and the prediction of amino acid-basepair motifs mediating protein-nucleic acid recognition

Biophysical Journal, 2022
Fifty years ago, the first atomic-resolution structure of a nucleic acid double helix, the mini-duplex (ApU)2, revealed details of basepair geometry, stacking, sugar conformation, and backbone torsion angles, thereby superseding earlier models based on x-ray fiber diffraction, including the original DNA double helix proposed by Watson and Crick. Just 3
Martin Egli, Shuguang Zhang
openaire   +2 more sources

Smoothing 3D Protein Structure Motifs Through Graph Mining and Amino Acid Similarities

Journal of Computational Biology, 2014
One of the most powerful techniques to study proteins is to look for recurrent fragments (also called substructures), then use them as patterns to characterize the proteins under study. Although protein sequences have been extensively studied in the literature, studying protein three-dimensional (3D) structures can reveal relevant structural and ...
Wajdi Dhifli, Rabie Saidi, Engelbert Mephu Nguifo   +2 more
exaly   +4 more sources

Occurrence of six-amino-acid motifs in three eukaryotic proteomes

Molecular Biology, 2012
Currently 18 hereditary neurological diseases are known to be associated with such mutations as multiple insertions of a single amino acid into the protein sequence. Therefore, investigation of the functional purpose of simple amino acid motifs becomes an important biological task.
M. Yu. Lobanov, N. S. Bogatyreva, O. V. Galzitskaya   +2 more
exaly   +2 more sources

Search for Functionally Significant Motifs and Amino Acid Residues of Actin

Molecular Biology, 2018
The scientific interest to the structural and functional properties of actin is determined by its abundance in cells. Being an important component of the cytoskeleton, actin is involved in many protein-protein interactions. Using crystal structures and molecular models, we have mapped the amino acid residues that are involved in these interactions and ...
T S, Tikhomirova, R S, Ievlev, M Yu, Suvorina, L G, Bobyleva, I M, Vikhlyantsev, A K, Surin, O V, Galzitskaya   +6 more
openaire   +2 more sources

Multiple Trypanosoma cruzi antigens containing tandemly repeated amino acid sequence motifs

Molecular and Biochemical Parasitology, 1988
Chromosomal DNA from Trypanosoma cruzi, the agent of the American trypanosomiasis (Chagas' disease), was used for construction of a DNA library, employing the expression vector lambda gt11. Nine clones encoding different parasite antigens were isolated from this library by screening with an antiserum from a Chagasic patient.
C F, Ibañez, J L, Affranchino, R A, Macina, M B, Reyes, S, Leguizamon, M E, Camargo, L, Aslund, U, Pettersson, A C, Frasch   +8 more
openaire   +2 more sources

Mutational analysis of conserved amino-acid motifs in EcoKI adenine methyltransferase

Gene, 1995
The EcoKI methyltransferase (M.EcoKI, MTase) contains the amino acid (aa) sequences AAGTA and NPPF believed to represent the two sequences that are strongly conserved in adenine MTases [Klimasauskas et al., Nucleic Acids Res. 17 (1989) 9823-9831]. We have analysed a mutation in the first sequence that abolishes cofactor binding and enzyme activity, and
D T, Dryden, D F, Willcock, N E, Murray
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Covariance analysis of RNA recognition motifs identifies functionally linked amino acids

Journal of Molecular Biology, 2001
The RNA recognition motif (RRM) is one of the most common eukaryotic protein motifs. RRM sequences form a conserved globular structure known as the RNA-binding domain (RBD) or the ribonucleoprotein domain. Many proteins that contain RRM sequences bind RNA in a sequence-specific manner.
S, Crowder, J, Holton, T, Alber
openaire   +2 more sources