Results 61 to 70 of about 257,865 (254)

Structure-Function Analysis of Diacylglycerol Acyltransferase Sequences from 70 Organisms

BMC Research Notes, 2011
Background Diacylglycerol acyltransferase families (DGATs) catalyze the final and rate-limiting step of triacylglycerol (TAG) biosynthesis in eukaryotic organisms.
Cao Heping
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Using weakly conserved motifs hidden in secretion signals to identify type-III effectors from bacterial pathogen genomes.

PLoS ONE, 2013
BackgroundAs one of the most important virulence factor types in gram-negative pathogenic bacteria, type-III effectors (TTEs) play a crucial role in pathogen-host interactions by directly influencing immune signaling pathways within host cells.
Xiaobao Dong, Yong-Jun Zhang, Ziding Zhang   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

BMC Evolutionary Biology, 2007
Background Non-ribosomal peptide synthetases (NRPSs) are large multimodular enzymes that synthesize a wide range of biologically active natural peptide compounds, of which many are pharmacologically important.
Wohlleben Wolfgang, Weber Tilmann, Hoof Ilka, Rausch Christian, Huson Daniel H   +4 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

NullSeq: A Tool for Generating Random Coding Sequences with Desired Amino Acid and GC Contents.

PLoS Computational Biology, 2016
The existence of over- and under-represented sequence motifs in genomes provides evidence of selective evolutionary pressures on biological mechanisms such as transcription, translation, ligand-substrate binding, and host immunity. In order to accurately
Sophia S Liu, Adam J Hockenberry, Andrea Lancichinetti, Michael C Jewett, Luís A N Amaral   +4 more
doaj   +1 more source

Overexpression of Medicago sativa LEA4-4 can improve the salt, drought, and oxidation resistance of transgenic Arabidopsis.

PLoS ONE, 2020
Late embryogenesis abundant (LEA) proteins are widely involved in many adverse conditions among plants. In this study, we isolated a LEA4 gene from alfalfa (Medicago sativa L.) termed MsLEA4-4 via a homology cloning strategy.
Huili Jia, Xuemin Wang, Yonghong Shi, Xinming Wu, Yunqi Wang, Jianning Liu, Zhihong Fang, Chunyan Li, Kuanhu Dong   +8 more
doaj   +1 more source

Amino acid sequence motifs and mechanistic features of the membrane translocation of α‐synuclein

Journal of Neurochemistry, 2006
AbstractMany lines of evidence suggest that α‐synuclein can be secreted from cells and can penetrate into them, although the detailed mechanism is not known. In this study, we investigated the amino acid sequence motifs required for the membrane translocation of α‐synuclein, and the mechanistic features of the phenomenon.
Keun Jae, Ahn, Seung R, Paik, Kwang Chul, Chung, Jongsun, Kim   +3 more
openaire   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source