Results 51 to 60 of about 405,820 (287)

Molecular insights into the VIRESCENS amino acid sequence and its implication in anthocyanin production in red- and yellow-fruited cultivars of date palm

Scientific Reports, 2023
This study examined the amino acid sequence of the VIRESCENS gene (VIR), which regulates the production of anthocyanin in 12 cultivars of the date palm (Phoenix dactylifera L.), grown in Al-Madinah Al-Munawarah of the Kingdom of Saudi Arabia.
Nadia M. Alsuhaimi, Nadia S. Al-Kaff
doaj   +1 more source

Length-Dependent Transition from Extended to Folded Shapes in Short Oligomers of an Azetidine-Based α-Amino Acid: The Critical Role of NH···N H-Bonds

Molecules, 2023
Hydrogen bonds (H-bonds) are ubiquitous in peptides and proteins and are central to the stabilization of their structures. Inter-residue H-bonds between non-adjacent backbone amide NH and C=O motifs lead to the well-known secondary structures of helices,
Dayi Liu, Jean-Xavier Bardaud, Zeynab Imani, Sylvie Robin, Eric Gloaguen, Valérie Brenner, David J. Aitken, Michel Mons   +7 more
doaj   +1 more source

Functionally different PIN proteins control auxin flux during bulbil development in Agave tequilana [PDF]

, 2015
In Agave tequilana, reproductive failure or inadequate flower development stimulates the formation of vegetative bulbils at the bracteoles, ensuring survival in a hostile environment.
Abraham Juarez, Maria Jazmin, Cardenas, Rocio Hernandez, Hake, Sarah, O'Connor, Devin, Ordaz-ortiz, Jose, Santoyo Villa, Jose Natzul, Simpson, June, Sluis, Aaron, Terry, Leon A.   +8 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Molecular evolution of HoxA13 and the multiple origins of limbless morphologies in amphibians and reptiles [PDF]

, 2015
Developmental processes and their results, morphological characters, are inherited through transmission of genes regulating development. While there is ample evidence that cis-regulatory elements tend to be modular, with sequence segments dedicated to ...
Bamshad M, Bell MA, Brakefield PM, Brakefield PM, Brayer KJ, Cohn M, Crow KD, Delport W, Di-Poï N, Dollé P, Dollé P, Fromental-Ramain C, Galant R, Gans C, Goodman FR, Gower DJ, Graur D, Günter P. Wagner, Hall BK, Head JJ, Hsieh-Li HM, Innis JW, Knosp WM, Knosp WM, Kobayashi A, Kohlsdorf T, Koryu Kin, Krumlauf R, Lande R, Lynch VJ, Lynch VJ, Mansfield JH, Mariana B. Grizante, Mariana F. Nery, Marina E. Singarete, Mortlock DP, Mortlock DP, Mortlock DP, Murrell B, Parra-Olea G, Pavlicev M, Pavlicev M, Pearson JC, Perez WD, Pyron AR, Pyron RA, Raff RA, Reno PL, Ronshaugen M, San Mauro D, Sarah R. Milograna, Shou S, Sivanantharajah L, Stadler HS, Stern DL, Taylor HS, Thompson JD, Tiana Kohlsdorf, Tschopp P, Warot X, Wiens JJ, Woltering JM, Woltering JM, Wray GA, Yang Z, Yang Z, Zhang J   +66 more
core   +4 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Asymmetric synthesis of β-amino acid derivatives by stereocontrolled C(sp3)-C(sp2) cross-electrophile coupling via radical 1,2-nitrogen migration

Nature Communications
Optically pure non-natural β-amino acids are noteworthy molecular motifs of numerous pharmaceutically important molecules. Skeletal editing of abundant α-amino acid scaffolds via tandem radical 1,2-N-shift/cross-coupling represents a powerful tool to ...
Zicheng Liao, Zijun Li, Meiqiu Xiao, Youlin Deng, Zehan Ma, Lijuan Zhou, Gangliang Dai, Xinyu Li, Shuowen Wang, Shilu Chen, Jinheng Li, Shi Tang   +11 more
doaj   +1 more source

MDD-Palm: Identification of protein S-palmitoylation sites with substrate motifs based on maximal dependence decomposition.

PLoS ONE, 2017
S-palmitoylation, the covalent attachment of 16-carbon palmitic acids to a cysteine residue via a thioester linkage, is an important reversible lipid modification that plays a regulatory role in a variety of physiological and biological processes. As the
Shun-Long Weng, Hui-Ju Kao, Chien-Hsun Huang, Tzong-Yi Lee   +3 more
doaj   +1 more source

Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation [PDF]

, 2006
APOBEC3G and APOBEC3F restrict human immunodeficiency virus type 1 (HIV-1) replication in vitro through the induction of G!92A hypermutation; however, the relevance of this host antiviral strategy to clinical HIV-1 is currently not known.
Pace, C., Keller, J., Nolan, D., James, I., Gaudieri, S., Moore, C., Mallal, S.   +6 more
core   +2 more sources