Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics. [PDF]
, 2018 Novel metabolites distinct from canonical pathways can be identified through the integration of three cheminformatics tools: BinVestigate, which queries the BinBase gas chromatography-mass spectrometry (GC-MS) metabolome database to match unknowns with ...
A El-Tayeb +45 more
core +1 more source
Chemistry – A European Journal, EarlyView.The tCAP(N3) reagent, featuring a stable and self‐activating precursor, enables site‐specific conjugation of native IgGs. This Fc‐affinity peptide approach selectively transfers an Ac‐Lys(N3)‐Gly‐Gly payload to Lys248, producing divalently azidated antibody while preserving its biological function.
Hiroko Kawakami +12 more
wiley +1 more source
Effect of different conditions on the germination of coix seed and its characteristics analysis
Food Chemistry: XCoix seed (CS) has high nutritional value, but the deep processing of CS is relatively limited. Sprouting can significantly improve nutritional value, laying the foundation for efficient consumption or further processing.
Lidan Dong +6 more
doaj +1 more source
Analysis of Receptor’s Distribution in Entorhinal Cortex after Induction of Spreading Depression in Juvenile Rats [PDF]
, 2015 Spreading depression (SD), discovered by Leao in 1944, is a pathophysiological wave which propagates slowly in the brain (3 mm/min) and cause dramatic ionic and hemodynamic changes.
Alizadeh, L., Ghaemi, A., Lotfinia, A.A.
core
Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures [PDF]
, 2019 The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites.
Andrews, Peter M. +11 more
core +2 more sources
Surveillance of Phenibut in Wastewater During a Brazilian Carnival
Drug Testing and Analysis, EarlyView.This study reports the first detection of phenibut in Brazilian wastewater. Phenibut, a substance readily sold online to improve concentration, reaches wastewater treatment plants (WWTPs) after consumption by the population. Samples from WWTPs in the cities of Recife and Olinda in Northeastern Brazil were collected during the world's largest Carnival ...
Bruna R. de S. Gomes +5 more
wiley +1 more source
Sustainability in Analytical Chemistry Illustrated by Pharmaceutical Nitrosamine Testing
ELECTROPHORESIS, EarlyView.ABSTRACT Following the valsartan scandal in 2018, the testing of drug substances and drug products for N‐nitrosamines has become a critical and mandatory quality control measure. The European Pharmacopoeia chapter 2.5.42 currently describes three analytical methods for this purpose: HPLC–MS/MS, GC–MS, and GC–MS/MS.
Felix Bredendiek +2 more
wiley +1 more source
STANDARDIZATION OF THE AMINO ACIDS TABLETS BY DIFFUSE REFLECTION IR SPECTROSCOPY
Разработка и регистрация лекарственных средств, 2019 The possibility of using the infrared spectra of the diffuse reflection in the near and medium field of standardization and optimization of the technological process of tablet forms of aliphatic amino acids: butyric, β-alanine, γ-aminobutyric acid. Shown
A. A. Maryin +2 more
doaj
GABAergic neurons in the medullary raphé possess network independent chemosensitivity in situ [PDF]
, 2012 The identity and location of central pH/CO2 sensitive chemoreceptors are not fully understood. Serotonin (5-HT) and γ-aminobutyric acid (GABA) synthesizing neurons in the medullary raphé have demonstrated intrinsic chemosensitivity in vitro.
Iceman, Kimberly E.
core
Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ‐aminobutyric acid type B receptor activity [PDF]
, 2012 Ricka Messer, Eric S. Levine
openalex +1 more source