Results 121 to 130 of about 5,128,888 (403)

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA_A receptor-mediated inhibition [PDF]

, 2014
Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Alkire, Andrada, Angel, Belelli, Belelli, Belelli, Bonin, Brickley, Chandra, Ching, Cope, Coulter, Farrant, Fiset, Franks, Franks, Gili, Glykys, Hales, Herd, Herd, Hill-Venning, Hofbauer, Huguenard, Iyer, Jensen, Jia, Jia, Jurd, Kasugai, Kralic, Kralic, Kralic, Kralic, Krosigk, McKernan, Mihalek, Olsen, Orser, Peden, Peng, Pistis, Purdon, Reynolds, Rudolph, Rudolph, Steriade, Steriade, Sur, Talavera, Thomson, Tretter, Uchida, Wafford, White, Yang, Ying, Ying   +57 more
core   +2 more sources

Acid zeta function and ajoint acid zeta function [PDF]

arXiv, 2010
In this paper we set up the theory of acid zeta function and ajoint acid zeta function, based on the theory, we point out a reason to doubt the truth of the Riemann hypothesis and also as a consequence, we give out some new RH equivalences.
arxiv  

γ-Aminobutyric Acid Regulates Both the Survival and Replication of Human β-Cells

Diabetes, 2013
γ-Aminobutyric acid (GABA) has been shown to inhibit apoptosis of rodent β-cells in vitro. In this study, we show that activation of GABAA receptors (GABAA-Rs) or GABAB-Rs significantly inhibits oxidative stress–related β-cell apoptosis and preserves ...
Jide Tian, H. Dang, Zheying Chen, Alice Guan, Yi-Ping Jin, M. Atkinson, D. Kaufman   +6 more
semanticscholar   +1 more source

Synthetic amino acid-analogs of γ-aminobutyric acid

Bulletin of the Chemical Society of Ethiopia, 1989
Bull. Chem. Soc. Ethiop., 2(2) 57-60 (1989).
I.M. Ejimadu
doaj  

The Role of GABA and Insulin Regulated Aminopeptidase on Insulin Resistance and GLUT4 in Prediabetes and Type 2 Diabetes Mellitus

مجله كليه طب الكندي
Background: Different proposed mechanisms for insulin resistance have been put forth to understand the relationship and changes in insulin resistance. Looking at the levels of insulin, the neurotransmitter gamma-aminobutyric acid, glucose transport type
Ismael Sadeq Khashan, Maysaa Jalal Majeed   +1 more
doaj   +1 more source

Changes in Descending Pain Modulation During Anti–Tumor Necrosis Factor Therapy: A Prospective Study in Rheumatoid Arthritis and Spondyloarthritis

Arthritis &Rheumatology, EarlyView.
Objective In rheumatoid arthritis (RA) and spondyloarthritis (SpA), managing persistent pain remains challenging. Little is known regarding impaired pain pathways in these patients and the impact of biologic disease‐modifying antirheumatic drugs (bDMARDs).
Anne‐Priscille Trouvin, Arielle Simunek, Joël Coste, Terkia Medkour, Alice Combier, Lucile Poiroux, François Vidal, Sandrine Carvès, Didier Bouhassira, Serge Perrot   +9 more
wiley   +1 more source

High‐field ex vivo and in vivo two‐dimensional nuclear magnetic resonance spectroscopy in murine brain: Resolving and exploring the molecular environment

NMR in Biomedicine, Volume 36, Issue 2, February 2023., 2023
The molecular environment in the murine brain was explored both in and ex vivo at high (14.1‐ and 15.2‐T) fields, using homonuclear and heteronuclear 2D NMR techniques. These revealed approximately 10 and 29 metabolites, respectively, and led to the assignment of 137 cross‐peaks in total.
Ricardo P. Martinho, Mukul G. Jain, Lucio Frydman   +2 more
wiley   +1 more source

Is Amino-Acid Homochirality Due To Asymmetric Photolysis In Space? [PDF]

arXiv, 1999
Amino acids occurring in proteins are, with rare exceptions, exclusively of the L-configuration. Among the many scenarios put forward to explain the origin of this chiral homogeneity (i.e., homochirality), one involves the asymmetric photolysis of amino acids present in space, triggered by circularly polarized UV radiation.
arxiv  

Coordination of opposing sex-specific and core muscle groups regulates male tail posture during Caenorhabditis elegans male mating behavior [PDF]

, 2009
Background To survive and reproduce, animals must be able to modify their motor behavior in response to changes in the environment. We studied a complex behavior of Caenorhabditis elegans, male mating behavior, which provided a model for understanding ...
A Barrios, A Jones, A Jones, AA Beg, Allyson J Whittaker, BA Bamber, BB Wang, BJ Dickinson, C Loer, C Trent, D Weinshenker, DM Raizen, E Culetto, EM Gabriel, G Schindelman, H Ogawa, I Bany, I Putrenko, J Lewis, J Rand, J Richmond, J Srinivasan, J Sulston, J Sze, J White, JQ White, JT Fleming, K Liu, L Carnell, L Garcia, LE Waggoner, M Zhang, MM Francis, O Saifee, P Towers, Paul W Sternberg, RE Ritzmann, S Brenner, S Clark, SH Chalasani, SL McIntire, T Liu, W Schafer, Y Jin, Y Jin, Y Liu   +45 more
core   +3 more sources

Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder.

Bipolar Disorders, 2013
OBJECTIVES Gamma-aminobutyric acid (GABA) abnormalities have been implicated in bipolar disorder. However, due to discrepant studies measuring postmortem, cerebrospinal fluid, plasma, and in vivo brain levels of GABA, the nature of these abnormalities is
R. Brady, Julie M. McCarthy, Julie M. McCarthy, A. Prescot, J. Jensen, A. Cooper, Bruce M. Cohen, Bruce M. Cohen, P. Renshaw, Dost Öngür, Dost Öngür   +10 more
semanticscholar   +1 more source