Results 121 to 130 of about 5,172,296 (338)

Research Progress of γ-Aminobutyric Acid (GABA)

open access: yesShipin gongye ke-ji
γ-aminobutyric acid (GABA) is a non-protein amino acid discovered in animals, plants, and microorganisms that was approved as the "new resource food" by the National Health Commission of the People's Republic of China (NHC) in 2009.
Junping ZHOU   +7 more
doaj   +1 more source

Analysis of Receptor’s Distribution in Entorhinal Cortex after Induction of Spreading Depression in Juvenile Rats [PDF]

open access: yes, 2015
Spreading depression (SD), discovered by Leao in 1944, is a pathophysiological wave which propagates slowly in the brain (3 mm/min) and cause dramatic ionic and hemodynamic changes.
Alizadeh, L., Ghaemi, A., Lotfinia, A.A.
core  

Action of Phenylalanine Metabolites on Glutamic Acid Decarboxylase and gamma-Aminobutyric Acid---alpha-Ketoglutaric Acid Transaminase in Brain. [PDF]

open access: bronze, 1959
Arne Hanson   +5 more
openalex   +1 more source

Synaptic inhibition and γ-aminobutyric acid in the mammalian central nervous system

open access: yesProceedings of the Japan Academy. Series B, Physical and biological sciences, 2013
Signal transmission through synapses connecting two neurons is mediated by release of neurotransmitter from the presynaptic axon terminals and activation of its receptor at the postsynaptic neurons.
K. Obata
semanticscholar   +1 more source

Combination vs. single‐drug nonprescription analgesics for acute pain management: A narrative review

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Combining nonprescription analgesics with different mechanisms of action has been proposed as a rational strategy to optimize the management of acute pain. This review assessed the efficacy and safety of nonprescription analgesics, including paracetamol (acetaminophen), metamizole and nonsteroidal anti‐inflammatory drugs (NSAIDs) used in combination vs.
Ali Mobasheri   +5 more
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

open access: yesBMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu   +7 more
wiley   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

open access: yesCancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu   +12 more
wiley   +1 more source

The Effect of Exogenously Applied Dicarboxylic Acids (Photon) on the Maize (Zea mays) Metabolite Profile

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Maize is an important crop worldwide with approximately 1200 million tons consumed and a market size worth $143 billion. Environmental stress influence production of crops and mitigating these ensures optimum production. Dicarboxylic acids are known as emulsifying agents that mitigate various stresses in plants.
Mhlonipheni Msomi   +3 more
wiley   +1 more source

GABA-modulating bacteria of the human gut microbiota. [PDF]

open access: yes, 2019
The gut microbiota affects many important host functions, including the immune response and the nervous system1. However, while substantial progress has been made in growing diverse microorganisms of the microbiota2, 23-65% of species residing in the ...
Clardy, Jon   +18 more
core  

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade   +4 more
wiley   +1 more source

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