Involvement of Matrix Metalloproteinases (MMP-2 and MMP-9), Inflammasome NLRP3, and Gamma-Aminobutyric Acid (GABA) Pathway in Cellular Mechanisms of Neuroinflammation in PTSD. [PDF]
Grzesińska A, Ogłodek EA.
europepmc +1 more source
Bumetanide Treatment in 15 Children With Autism: A Randomised Waitlist‐Control Study
ABSTRACT Aim Bumetanide, a diuretic, influences neuronal chloride homeostasis and potentially restores GABAergic inhibition and neuronal signalling balance. This mechanism may contribute to improvements in autism‐related symptoms. The present study builds on the preclinical research and on previous clinical research on bumetanide treatment for children
Elisabeth Fernell+7 more
wiley +1 more source
Optimization of γ-Aminobutyric Acid Production in Brown Rice via Prolonged Seed Priming. [PDF]
Xu L+7 more
europepmc +1 more source
Cerebellar defects are a primary pathology in mouse models of spinal muscular atrophy
Purkinje cell (PC) degeneration is localized to posterior lobules in the cerebellum, and rescue of survival motor neuron protein expression levels in motor neurons does not ameliorate this effect. Representative images of sagittal cerebellar sections stained with anti‐calbindin in the vermis and hemisphere at P12 for wild type, ChATCre+ rescue (Rescue),
Nicholas C. Cottam+9 more
wiley +1 more source
Insights and progress on the biosynthesis, metabolism, and physiological functions of gamma-aminobutyric acid (GABA): a review. [PDF]
Zhang Q+16 more
europepmc +1 more source
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai+13 more
wiley +1 more source
Unveiling the potential biochemical effects of selected heterocyclic compounds as human Type-A γ-aminobutyric acid (GABA A) Modulator: An <i>Insilico</i> Approach. [PDF]
Oyebamiji AK+9 more
europepmc +1 more source