Results 21 to 30 of about 5,172,296 (338)

Sedative-like effect of intraperitoneal GABA administration in the open field test [PDF]

, 2016
Gamma-Amino Butyric Acid (GABA) is the main inhibitor neurotransmitter of the Central Nervous System (CNS). Its peripheral administration has been matter of discussion. On the one hand, it has been reported that it does not cross the Blood-Brain Barrier (
Gargiulo, Augusto Pascual Ítalo, Gargiulo, Pascual Angel, Guevara, Manuel Alejandro, Lafuente, José Vicente, Landa, Adriana Inés, Marquez Herrero, Santiago, Mesones, Humberto Luis, Romanowicz, Esteban Alejandro   +7 more
core   +1 more source

Regulation of Arabidopsis 14-3-3 gene expression by GABA. [PDF]

, 2006
The function in plants of the non-protein amino acid, gamma-aminobutyric acid (GABA) is poorly understood. In this study, we show that GABA down-regulates the expression of a large sub-set of 14-3-3 gene family members in Arabidopsis thaliana seedlings ...
Lancien, Muriel, Roberts, Michael R
core   +1 more source

Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders [PDF]

, 2004
Background Cerebral palsy (CP) is an heterogeneous group of neurological disorders of movement and/or posture, with an estimated incidence of 1 in 1000 live births.
A Lernmark, Alex F Markham, B Hagberg, BG Condie, C Geoffrey Woods, CL Fawer, Clare N Lynex, CM Wiles, David T Bonthon, DF Bu, DF Bu, DJ Stone, DL Martin, DL Martin, DP McHale, DP McHale, E Maestrini, Eamonn R Maher, F Sandbrink, G Gaffney, GE Homanics, H Asada, H Mitoma, HM Meinck, I Hughes, Ian M Carr, J Kim, J Volpe, Jack P Leek, JO Forfar, JS Lappalainen, K Burk, K Dinkel, KCK Kuban, KH Gustavson, LM Dubowitz, LM Levy, M Baraitser, M Solimena, M Solimena, MC Dalakas, MG Erlander, MH Butler, N Laprade, N Paneth, POD Pharoah, PS Eicher, PT Bosma, Rajgopal Achuthan, RW Bond, S Bundey, S Chattopadhyay, S Kono, S Kure, S Mitchell, SD Chessler, Simon Mitchell, V Cormier-Daire   +57 more
core   +2 more sources

Multiplexed CRISPR/Cas9‐mediated metabolic engineering of γ‐aminobutyric acid levels in Solanum lycopersicum

Plant Biotechnology Journal, 2017
Summary In recent years, the type II CRISPR system has become a widely used and robust technique to implement site‐directed mutagenesis in a variety of species including model and crop plants. However, few studies manipulated metabolic pathways in plants
Rui Li, Ran Li, Xindi Li, D. Fu, B. Zhu, H. Tian, Yunbo Luo, Hongliang Zhu   +7 more
semanticscholar   +1 more source

Optimization of Gamma-Aminobutyric Acid Production in Probiotics Extracted from Local Dairy Products in West Region of Iran using MRS broth and Whey Protein Media

Applied Food Biotechnology, 2018
Background and objective: Gamma-aminobutyric acid is a non-protein amino acid produced by lactic acid bacteria in fermented foods and includes unique functions in the human biological system.
Fatemeh Zarei, Leila Nateghi, Mohamad Reza Eshaghi, Maryam Ebrahimi Taj Abadi   +3 more
doaj   +1 more source

γ-Aminobutyric acid (GABA) and ectoine (ECT) impacts with and without AMF on antioxidants, gas exchange attributes and nutrients of cotton cultivated in salt affected soil

BMC Plant Biology, 2023
Salinity stress is one of the major hurdles in agriculture which adversely affects crop production. It can cause osmotic imbalance, ion toxicity that disrupts essential nutrient balance, impaired nutrient uptake, stunted growth, increased oxidative ...
Yuhan Ma, Ping Huang, Shoucheng Huang, Uzma Younis, Ghulam Sabir Hussain, Shah Fahad, Subhan Danish, Mohamed Soliman Elshikh, Humaira Rizwana   +8 more
doaj   +1 more source

Visual cortical γ−aminobutyric acid and perceptual suppression in amblyopia

Frontiers in Human Neuroscience, 2022
In amblyopia, abnormal visual experience during development leads to an enduring loss of visual acuity in adulthood. Physiological studies in animal models suggest that intracortical GABAergic inhibition may mediate visual deficits in amblyopia.
Arjun Mukerji, Arjun Mukerji, Kelly N. Byrne, Kelly N. Byrne, Kelly N. Byrne, Eunice Yang, Eunice Yang, Dennis M. Levi, Dennis M. Levi, Dennis M. Levi, Dennis M. Levi, Michael A. Silver, Michael A. Silver, Michael A. Silver, Michael A. Silver   +14 more
doaj   +1 more source

Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]

, 2014
BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
core   +2 more sources

Efficient increase of ɣ-aminobutyric acid (GABA) content in tomato fruits by targeted mutagenesis

Scientific Reports, 2017
γ-Aminobutyric acid (GABA) is a non-proteinogenic amino acid that has hypotensive effects. Tomato (Solanum lycopersicum L.) is among the most widely cultivated and consumed vegetables in the world and contains higher levels of GABA than other major crops.
Satoko Nonaka, Chikako Arai, Mariko Takayama, C. Matsukura, H. Ezura   +4 more
semanticscholar   +1 more source

GABA transaminase deficiency. Case report and literature review

Clinical Case Reports, 2021
GABA transaminase deficiency should be considered in the differential diagnosis of early onset epileptic encephalopathies. This case was diagnosed post‐mortem, but increased vigilance to this will allow for earlier diagnoses in other infants and families.
Amira Oshi, Abdullah Alfaifi, Mohammed Z. Seidahmed, Khalid Al Hussein, Abeer Miqdad, Abdelmohsin Samadi, Omar Abdelbasit   +6 more
doaj   +1 more source