Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit [PDF]
The Journal of Biological Chemistry 279, 16 (2004) 15824-30, 2008 The gamma-aminobutyric acid type B (GABAB) receptor is an allosteric complex made of two subunits, GABAB1 (GB1) and GABAB2 (GB2). Both subunits are composed of an extracellular Venus flytrap domain (VFT) and a heptahelical domain (HD). GB1 binds GABA, and GB2 plays a major role in G-protein activation as well as in the high agonist affinity state of ...
arxiv +1 more source
An autocrine role for pituitary GABA: Activation of GABA-B receptors and regulation of growth hormone levels [PDF]
, 2002 There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs.
Corsi, C. +5 more
core +1 more source
Visual cortical γ−aminobutyric acid and perceptual suppression in amblyopia
Frontiers in Human Neuroscience, 2022 In amblyopia, abnormal visual experience during development leads to an enduring loss of visual acuity in adulthood. Physiological studies in animal models suggest that intracortical GABAergic inhibition may mediate visual deficits in amblyopia.
Arjun Mukerji +14 more
doaj +1 more source
DETERMINATION OF GAMMA - AMINOBUTYRIC ACID BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY [PDF]
Acta Medica Iranica, 1998 Gamma-aminobutyric acid is the main inhibitory amino acid neurotransmitter in several areas of the brain. Measurement of gamma-aminobutyric acid in the brain will help elucidate its metabolic rote and diagnostic value.
D. Qujeq
doaj +2 more sources
Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons [PDF]
Cellular Signalling 19, 9 (2007) 1996-2002, 2008 gamma-aminobutyric acid type B (GABA(B)) receptor is an allosteric complex made of two subunits, GABA(B1) and GABA(B2). GABA(B2) plays a major role in the coupling to G protein whereas GABA(B1) binds GABA. It has been shown that GABA(B) receptor activates ERK(1/2) in neurons of the central nervous system, but the molecular mechanisms underlying this ...
arxiv +1 more source
Priming of plant innate immunity by rhizobacteria and beta-aminobutyric acid: differences and similarities in regulation [PDF]
, 2009 P>Pseudomonas fluorescens WCS417r bacteria and beta-aminobutyric acid can induce disease resistance in Arabidopsis, which is based on priming of defence.
Czechowski, T. +6 more
core +1 more source
The priming molecule β-aminobutyric acid is naturally present in plants and is induced by stress.
New Phytologist, 2017 The defense system of a plant can be primed for increased defense, resulting in an augmented stress resistance and/or tolerance. Priming can be triggered by biotic and abiotic stimuli, as well as by chemicals such as β-aminobutyric acid (BABA), a ...
D. Thevenet +7 more
semanticscholar +1 more source
GABA transaminase deficiency. Case report and literature review
Clinical Case Reports, 2021 GABA transaminase deficiency should be considered in the differential diagnosis of early onset epileptic encephalopathies. This case was diagnosed post‐mortem, but increased vigilance to this will allow for earlier diagnoses in other infants and families.
Amira Oshi +6 more
doaj +1 more source
Shipin gongye ke-ji, 2022 The effect of exogenous γ-aminobutyric acid (GABA) and GABA synthesis inhibitor 3-mercaptopropionic acid (3-MP) on GABA metabolism and quality in fresh-cut pumpkin was investigated, and the possible mechanism was studied.
Jingyi LIANG +4 more
doaj +1 more source
Urine amino acid and gamma aminobutyric acid level in COVID 19 patients [PDF]
Iran J MicrobiolBackground and Objectives: SARS CoV2 has tropism for various tissues, including the respiratory tract, brain, endothelium, heart, kidney and liver. Neurological symptoms can also be seen in the clinical course of the disease, and anosmia is the most ...
Kazezoglu C +6 more
europepmc +1 more source