Results 51 to 60 of about 5,172,296 (338)
Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]
, 2014 Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J +2 more
core +1 more source
FEBS Open Bio, EarlyView.The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo +4 more
wiley +1 more source
Synthesis of ketoprofen - L- phenylalanine and Ketoprofen -y- Aminobutyric acid ethyl esters as possible prodrugs [PDF]
المجلة العراقية للصيدلة, 2006 Ethyl ester HCI of the amino acids -L- phenylalanine and 7- Aminobutyric acid were synthesized through reaction of these amino acids with thionyl chloride in absolute ethanol.
Muthanna D.Saud +2 more
doaj +1 more source
Central Dysmyelination in SSADH‐Deficient Humans and Mice
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer +11 more
wiley +1 more source
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Erwin A. van Vliet +9 more
wiley +1 more source
Allosteric modulation of retinal GABA receptors by ascorbic acid [PDF]
, 2011 Ionotropic GABA receptors (GABAA and GABAC) belong to the Cys-loop receptor family of ligand-gated ion channels. GABAC receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells.
Aguayo, Luis G. +5 more
core +1 more source
2-Aminobutyric acid modulates glutathione homeostasis in the myocardium
Scientific Reports, 2016 A previous report showed that the consumption of glutathione through oxidative stress activates the glutathione synthetic pathway, which is accompanied by production of ophthalmic acid from 2-aminobutyric acid (2-AB).
Y. Irino +13 more
semanticscholar +1 more source
Arthritis Care &Research, EarlyView.As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox +3 more
wiley +1 more source
Differential Sensitivity of Maize Hybrids to Nicosulfuron
AgronomyMaize hybrids exhibit varying levels of tolerance to the herbicide nicosulfuron, influenced by the environment, plant developmental stage, and herbicide rate.
Natalia da Cunha Bevilaqua +6 more
doaj +1 more source
Frontiers in Plant Science, 2023 Salinity is one of the major abiotic stresses besides drought and cold stress. The application of plant growth regulators (PGRs) is an effective method to mitigate yield losses caused by salinity.
Maoxiang Zhao +9 more
doaj +1 more source