Results 71 to 80 of about 5,011,255 (292)

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård, Lotte Rasmussen, Morten Olesen, Anne Mette Skov Sørensen, Zandra Nymand Ennis, Joseph Kane, Sarah Baxter, Blánaid Hicks   +7 more
wiley   +1 more source

Isolation and identification of Monascus strains and its degradation treatment of pit bottom wastewater of the sauce-flavor Baijiu byproduct [PDF]

Zhongguo niangzao
To obtain Monascus spp. with high efficiency in degrading pit bottom wastewater from sauce-flavor (Jiangxiangxing) Baijiu production, Monascus strains were screened from sauce-flavor Baijiu Daqu using traditional cultivation methods and identified ...
LI Xuanchen, YANG Xin, CHENG Mai, LUO Yuena, ZHOU Jianli, QIU Shuyi
doaj   +1 more source

Midazolam: an essential palliative care drug

Palliative Care and Social Practice, 2020
Midazolam is a commonly used benzodiazepine in palliative care and is considered one of the four essential drugs needed for the promotion of quality care in dying patients.
Eric Prommer
doaj   +1 more source

Contribution of Addictovigilance data to assess adverse‐events linked to psychoactive substances in children and adolescents

British Journal of Clinical Pharmacology, EarlyView.
Aims We sought to characterize adverse events and deaths associated with the use of psychoactive substances in children and adolescents. Methods Two French Addictovigilance databases were analysed: spontaneous reports and deaths over the period 2016–2021, in subjects aged 10–<18 years. An unsupervised classification was implemented on consumption data (
Hélène Peyrière, Anne Batisse, Nathalie Fouilhé Sam‐Laï, Amélie Daveluy, Christine Fournier‐Choma, Sylvie Deheul, Cécile Chevalier, Clémence Lacroix, Valérie Gibaja, Aurélie Aquizerate, Stéphanie Pain, Emilie Jouanjus, Marie‐Christine Picot, Erika Nogue   +13 more
wiley   +1 more source

Effect of Constraint-Induced Movement Therapy on Motor Function of Rats with Cerebral Ischemia-Reperfusion Injury Based on Magnetic Resonance Spectroscopy Imaging

康复学报, 2023
ObjectiveAnimal magnetic resonance spectroscopy (MRS) imaging was used to detect the level of glutamate and γ-aminobutyric acid in motor cortex of rats, and to explore the regulatory effect of constraint-induced movement therapy (CIMT) on motor function ...
JIANG Pingli, CHEN Xiaocheng, XU Wenshan, DING Yanyi, LIU Weilin, TAO Jing   +5 more
doaj  

Improved Mixing Properties of Stirred Fermentation of an Aspergillus oryzae Hyphal Dispersion Mutant

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The complexity of mechanical and biological processes in filamentous fungal fermentation remains a major obstacle to improving product yield. We previously demonstrated that the AGΔ‐GAGΔ strain of Aspergillus oryzae, lacking both α‐1,3‐glucan (AG) and galactosaminogalactan (GAG), had improved hyphal dispersion, reduced culture viscosity, and ...
Shunya Susukida, Ken Miyazawa, Hikaru Ichikawa, Kiyoaki Muto, Akira Yoshimi, Toshitaka Kumagai, Yoshikazu Kato, Keietsu Abe   +7 more
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder.

Bipolar Disorders, 2013
OBJECTIVES Gamma-aminobutyric acid (GABA) abnormalities have been implicated in bipolar disorder. However, due to discrepant studies measuring postmortem, cerebrospinal fluid, plasma, and in vivo brain levels of GABA, the nature of these abnormalities is
R. Brady, Julie M. McCarthy, Julie M. McCarthy, A. Prescot, J. Jensen, A. Cooper, Bruce M. Cohen, Bruce M. Cohen, P. Renshaw, Dost Öngür, Dost Öngür   +10 more
semanticscholar   +1 more source

STANDARDIZATION OF THE AMINO ACIDS TABLETS BY DIFFUSE REFLECTION IR SPECTROSCOPY

Разработка и регистрация лекарственных средств, 2019
The possibility of using the infrared spectra of the diffuse reflection in the near and medium field of standardization and optimization of the technological process of tablet forms of aliphatic amino acids: butyric, β-alanine, γ-aminobutyric acid. Shown
A. A. Maryin, I. G. Tansereva, Y. G. Chistohin   +2 more
doaj  

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source