Results 81 to 90 of about 5,011,255 (292)

γ-Aminobutyric Acid Regulates Both the Survival and Replication of Human β-Cells

Diabetes, 2013
γ-Aminobutyric acid (GABA) has been shown to inhibit apoptosis of rodent β-cells in vitro. In this study, we show that activation of GABAA receptors (GABAA-Rs) or GABAB-Rs significantly inhibits oxidative stress–related β-cell apoptosis and preserves ...
Jide Tian, H. Dang, Zheying Chen, Alice Guan, Yi-Ping Jin, M. Atkinson, D. Kaufman   +6 more
semanticscholar   +1 more source

Synthesis of Substituted Imidazo[1,2‐a]pyridines, Imidazo[1,2‐a]pyrazines and Imidazo[1,2‐b]pyridazines by Multicomponent Reactions Using Green Solvents

European Journal of Organic Chemistry, EarlyView.
In an environmentally friendly process for synthesizing heterocyclic molecules of therapeutic interest, imidazo[1,2‐a]pyridine, imidazo[1,2‐a]pyrazine and imidazo[1,2‐b]pyridazine core structures are obtained by a multicomponent Groebke–Blackburn–Bienaymé reaction using bio‐based recyclable solvents.
Abdelkarim El Qami, Gatien Messire, Gaëtan Bouchery, Emma Caillet, Sloan Steiner, Sabine Berteina‐Raboin   +5 more
wiley   +1 more source

Contactless Conductivity Detection for Capillary Electrophoresis—Developments From 2020 to 2024

ELECTROPHORESIS, EarlyView.
ABSTRACT The review covering the development of capillary electrophoresis with capacitively coupled contactless conductivity detection from 2020 to 2024 is the latest in a series going back to 2004. The article considers applications employing conventional capillaries and planar lab‐on‐chip devices as well as fundamental and technical developments of ...
Peter C. Hauser, Pavel Kubáň
wiley   +1 more source

Submerged fermentation of Lactobacillus rhamnosus YS9 for γ-aminobutyric acid (GABA) production

Brazilian Journal of Microbiology, 2013
γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in central nervous system, and its application in drugs and functional foods has attracted great attention.
Q. Lin
semanticscholar   +1 more source

Action of Phenylalanine Metabolites on Glutamic Acid Decarboxylase and gamma-Aminobutyric Acid---alpha-Ketoglutaric Acid Transaminase in Brain. [PDF]

, 1959
Arne Hanson, Salo Gronowitz, Sigvard Eriksson, C.‐G. Hedén, Björn A. Malmgren, H. Palmstierna   +5 more
openalex   +1 more source

Synaptic inhibition and γ-aminobutyric acid in the mammalian central nervous system

Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2013
Signal transmission through synapses connecting two neurons is mediated by release of neurotransmitter from the presynaptic axon terminals and activation of its receptor at the postsynaptic neurons.
K. Obata
semanticscholar   +1 more source

Research Progress of γ-Aminobutyric Acid (GABA)

Shipin gongye ke-ji
γ-aminobutyric acid (GABA) is a non-protein amino acid discovered in animals, plants, and microorganisms that was approved as the "new resource food" by the National Health Commission of the People's Republic of China (NHC) in 2009.
Junping ZHOU, Yujuan XU, Jing WEN, Jijun WU, Yuanshan YU, Chuyuan LI, Shaoquan WENG, Min ZHAO   +7 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Resting‐state functional connectivity changes with microburst vagus nerve stimulation therapy

Epilepsia Open, EarlyView.
Abstract Objective Microburst vagus nerve stimulation (μVNS) may reduce seizure frequency in drug‐resistant epilepsy (DRE) via targeted thalamic plasticity. We prospectively investigated the role of thalamic resting‐state functional connectivity (rsFC) in μVNS effects and hypothesized a relationship between thalamic rsFC and long‐term seizure frequency
Jane B. Allendorfer, Rodolphe Nenert, Elhum Shamshiri, Giovanni Ranuzzi, Jason Begnaud, Ryan Verner, Jerzy P. Szaflarski, for the Microburst Study Group, Rebecca O’Dwyer, Michael Macken, Blake Newman, Cornelia Drees, Danielle McDermott, Lesley Kaye, Mesha Gay Brown, Muhammad Zafar, William Tatum, Selim Benbadis, Pegah Afra, Zeenat Jaisani, Kristl Vonck   +20 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source