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Spontaneous and pronase‐induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines

The Journal of Pathology, Volume 229, Issue 3, Page 390-399, February 2013., 2013
Abstract A subgroup of HER2‐overexpressing breast tumours co‐expresses p95$^{{\rm{HER2}}}$, a truncated HER2 receptor that retains a functional HER2 kinase domain but lacks the extracellular domain, thus impairing trastuzumab binding. We evaluated p95$^{{\rm{HER2}}}$ expression in 99 frozen breast carcinoma samples by western blot analysis.
Daniele Recupero +12 more
wiley +1 more source

Oat Protects against Diabetic Nephropathy in Rats via Attenuating Advanced Glycation End Products and Nuclear Factor Kappa B

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
Oat, a rich source of soluble fiber, was considered to have a possible preventive effect on the progression of diabetic nephropathy. The present study aimed to assess this preventive activity in a rat model of diabetic nephropathy. Adult Wister rats were injected by streptozotocin (65 mg/kg).
Abdulrahman L. Al-Malki, Ravirajsinh Jadeja +1 more
wiley +1 more source

Homogeneous carbonylations of renewable methyl pentenoates and other unusual olefins [PDF]

This thesis is dedicated to the catalytic conversion of the different isomers of methyl pentenoate as bio renewable resource that can be produced from lignocellulosic biomass.
Behrens, Stephan (gnd: 1208921878)
core +1 more source

Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes. [PDF]