Results 1 to 10 of about 45,854 (229)

Is “Physiological Lysis” in Viscoelastometry a Plasmin-Mediated Process? [PDF]

Diagnostics
Viscoelastic testing (VET) is widely used to guide hemostatic therapy in patients with coagulopathy. One important application is the detection of fibrinolysis, defined as a reduction in clot amplitude after maximum clot firmness (MCF), quantified as ...
Anikó Smudla, Herbert Schöchl, Andreas Calatzis, Csikós Richárd Gergely, János Fazakas   +4 more
doaj   +2 more sources

An exploratory plasma-based functional assay for phenotypic characterization of fibrinolysis in dysfibrinogenemia [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Congenital dysfibrinogenemia exhibits heterogeneous clinical phenotypes, ranging from bleeding to thrombosis. However, conventional fibrinogen assays primarily evaluate clot formation alone.
Atsuo Suzuki, Shuichi Okamoto, Nobuaki Suzuki, Shogo Tamura, Takeshi Kanematsu, Masashi Tomita, Tetsuhito Kojima, Tadashi Matsushita   +7 more
doaj   +2 more sources

Outcomes according to timely or delayed primary percutaneous coronary intervention or fibrinolysis in a national registry of patients with ST-segment elevation myocardial infarction [PDF]

Open Heart
Background Time to reperfusion is a predictor of long-term outcomes in ST-segment elevation myocardial infarction (STEMI). Timely primary percutaneous coronary intervention (PCI) is the preferred strategy recommended by guidelines.
Peter Kearney, Richard Armstrong, JJ Coughlan, Andrew Maree, Thomas J Kiernan, James Crowley, Mark Kennedy, Robert A Byrne, Godfrey Aleong, Andrew Street, Jack Laffan, Charles McCreery, Gavin Blake, Aaron Peace, Huixuan Gao   +14 more
doaj   +2 more sources

Neutrophil extracellular traps formation is associated with impaired clot retraction and fibrinolysis in asthma [PDF]

Frontiers in Immunology
BackgroundAsthma is associated with an elevated risk of venous thromboembolism and pulmonary embolism; its etiology is not completely understood.ObjectiveThis study was designed to investigate whether the formation of neutrophil extracellular traps (NET)
Tomasz Misztal, Maria Magdalena Tomasiak-Łozowska, Aleksandra Poznalska, Wiktoria Ciochanowska, Tomasz Rusak, Marcin Moniuszko   +5 more
doaj   +2 more sources

Fibrinolysis vs. primary percutaneous coronary intervention for ST‐segment elevation myocardial infarction cardiogenic shock

ESC Heart Failure, 2021
Aims There are limited contemporary data on the use of initial fibrinolysis in ST‐segment elevation myocardial infarction cardiogenic shock (STEMI‐CS). This study sought to compare the outcomes of STEMI‐CS receiving initial fibrinolysis vs.
Saraschandra Vallabhajosyula, Dhiran Verghese, Malcolm R. Bell, Dennis H. Murphree, Wisit Cheungpasitporn, P. Elliott Miller, Shannon M. Dunlay, Abhiram Prasad, Gurpreet S. Sandhu, Rajiv Gulati, Mandeep Singh, Amir Lerman, Bernard J. Gersh, David R. Holmes Jr, Gregory W. Barsness   +14 more
doaj   +1 more source

Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients.

PLoS ONE, 2021
BackgroundThe effect of alcohol on the outcome and fibrinolysis phenotype in trauma patients remains unclear. Hence, we performed this study to determine whether alcohol is a risk factor for mortality and fibrinolysis shutdown in trauma patients ...
Il-Jae Wang, Byung-Kwan Bae, Young Mo Cho, Suck Ju Cho, Seok-Ran Yeom, Sang-Bong Lee, Mose Chun, Hyerim Kim, Hyung-Hoi Kim, Sun Min Lee, Up Huh, Soo Young Moon   +11 more
doaj   +1 more source

Global coagulation assays to measure in vitro fibrinolysis

Thrombosis Update, 2021
(249/250 words): Introduction: Fibrinolysis is a critical component of hemostasis associated with poor outcomes if not treated early and effectively. Successful hemostasis management requires close fibrinolysis monitoring. The study aimed to compare the
Joao D. Dias, Ebrahim Shafizadeh, Jamie Leiriao, Jan Hartmann   +3 more
doaj   +1 more source

Fibrinolytic therapy use for ST-segment elevation myocardial infarction and long-term outcomes in China: 2-year results from the China Acute Myocardial Infarction Registry

BMC Cardiovascular Disorders, 2023
Background Data on fibrinolytic therapy use for ST-segment elevation myocardial infarction (STEMI) and long-term clinical outcomes in developing countries are limited.
Chao Wu, Ling Li, Shuqing Wang, Jianping Zeng, Jingang Yang, Haiyan Xu, Yanyan Zhao, Yang Wang, Wei Li, Chen Jin, Xiaojin Gao, Yuejin Yang, Shubin Qiao   +12 more
doaj   +1 more source

uPA-mediated plasminogen activation is enhanced by polyphosphate

Haematologica, 2020
Tissue plasminogen activator (tPA) and urokinase (uPA) differ in their modes of action. Efficient tPA-mediated plasminogen activation requires binding to fibrin.
Claire S. Whyte, Nicola J. Mutch
doaj   +1 more source

Investigation of the Relationship Between TAFI Plasma Levels and Hemorrhage in Patients with Crimean-Congo Hemorrhagic Fever and the Role of TAFI in the Disease Pathogenesis

Cerrahpaşa Medical Journal, 2021
Objective: Crimean-Congo hemorrhagic fever is a tick-borne viral infection presenting with fever and bleeding. Thrombin-activatable fibrinolysis inhibitor is a plasma procarboxypeptidase synthesized in the liver, causing downregulation of fibrinolysis ...
Hüsna Şengül Aşkın, Mehmet Parlak, Esra Laloğlu, Sinan Yılmaz, Lütfü Aşkın, Emine Parlak   +5 more
doaj   +1 more source