Results 1 to 10 of about 123,453 (307)

Outcomes according to timely or delayed primary percutaneous coronary intervention or fibrinolysis in a national registry of patients with ST-segment elevation myocardial infarction. [PDF]

Open Heart
Background Time to reperfusion is a predictor of long-term outcomes in ST-segment elevation myocardial infarction (STEMI). Timely primary percutaneous coronary intervention (PCI) is the preferred strategy recommended by guidelines.
Laffan J, Gao H, Street A, Coughlan JJ, Armstrong R, Maree A, Blake G, Kearney P, Crowley J, Kiernan TJ, McCreery C, Aleong G, Peace A, Kennedy M, Byrne RA.   +14 more
europepmc   +2 more sources

Abnormal plasma clot formation and fibrinolysis reveal bleeding tendency in patients with partial factor XI deficiency

Blood Advances, 2018
: Individuals with factor XI (FXI) deficiency have a variable bleeding risk that cannot be predicted from plasma FXI antigen or activity. This limitation can result in under- or overtreatment of patients and risk of bleeding or thrombosis.
Gillian N. Gidley, Lori A. Holle, John Burthem, Paula H.B. Bolton-Maggs, Feng-Chang Lin, Alisa S. Wolberg   +5 more
doaj   +2 more sources

Fibrinolysis: an illustrated review

Research and Practice in Thrombosis and Haemostasis, 2023
In response to vessel injury (or other pathological conditions), the hemostatic process is activated, resulting in a fibrous, cellular-rich structure commonly referred to as a blood clot.
R. Risman, Nicholas C. Kirby, Brittany E. Bannish, N. Hudson, V. Tutwiler   +4 more
semanticscholar   +1 more source

Beyond fibrinolysis: The confounding role of Lp(a) in thrombosis.

Atherosclerosis, 2022
Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are a causal risk factor for the development of atherothrombotic disorders including coronary heart disease.
M. Boffa
semanticscholar   +1 more source

Thrombin Activatable Fibrinolysis Inhibitor (TAFI): An Updated Narrative Review

International Journal of Molecular Sciences, 2021
Thrombin activatable fibrinolysis inhibitor (TAFI), a proenzyme, is converted to a potent attenuator of the fibrinolytic system upon activation by thrombin, plasmin, or the thrombin/thrombomodulin complex.
M. Sillen, P. Declerck
semanticscholar   +1 more source

Fibrinolysis Shutdown in COVID-19: Clinical Manifestations, Molecular Mechanisms, and Therapeutic Implications

Journal of the American College of Surgeons, 2021
The COVID-19 pandemic has introduced a global public health threat unparalleled in our history. The most severe cases are marked by ARDS attributed to microvascular thrombosis.
J. Meizoso, H. Moore, E. Moore
semanticscholar   +1 more source

Fibrinolysis vs. primary percutaneous coronary intervention for ST‐segment elevation myocardial infarction cardiogenic shock

ESC Heart Failure, 2021
Aims There are limited contemporary data on the use of initial fibrinolysis in ST‐segment elevation myocardial infarction cardiogenic shock (STEMI‐CS). This study sought to compare the outcomes of STEMI‐CS receiving initial fibrinolysis vs.
Saraschandra Vallabhajosyula, Dhiran Verghese, Malcolm R. Bell, Dennis H. Murphree, Wisit Cheungpasitporn, P. Elliott Miller, Shannon M. Dunlay, Abhiram Prasad, Gurpreet S. Sandhu, Rajiv Gulati, Mandeep Singh, Amir Lerman, Bernard J. Gersh, David R. Holmes Jr, Gregory W. Barsness   +14 more
doaj   +1 more source

Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients.

PLoS ONE, 2021
BackgroundThe effect of alcohol on the outcome and fibrinolysis phenotype in trauma patients remains unclear. Hence, we performed this study to determine whether alcohol is a risk factor for mortality and fibrinolysis shutdown in trauma patients ...
Il-Jae Wang, Byung-Kwan Bae, Young Mo Cho, Suck Ju Cho, Seok-Ran Yeom, Sang-Bong Lee, Mose Chun, Hyerim Kim, Hyung-Hoi Kim, Sun Min Lee, Up Huh, Soo Young Moon   +11 more
doaj   +1 more source

Fibrinolysis Shutdown Correlation with Thromboembolic Events in Severe COVID-19 Infection

Journal of the American College of Surgeons, 2020
Background COVID-19 predisposes patients to a prothrombotic state with demonstrated microvascular involvement. The degree of hypercoagulability appears to correlate with outcomes; however, optimal criteria to assess for the highest-risk patients for ...
F. Wright, T. Vogler, E. Moore, H. Moore, M. Wohlauer, Shane Urban, T. Nydam, Peter K. Moore, R. McIntyre   +8 more
semanticscholar   +1 more source

Disorders of Fibrinogen and Fibrinolysis.

Hematology/Oncology Clinics of North America, 2021
Fibrinogen plays a fundamental role in coagulation through its support for platelet aggregation and its conversion to fibrin. Fibrin stabilizes clots and serves as a scaffold and immune effector before being broken down by the fibrinolytic system.
Jori E. May, A. Wolberg, Ming Y. Lim
semanticscholar   +1 more source