Results 1 to 10 of about 47,940 (267)

Relationship Between Severity of Fibrinolysis Based on Rotational Thromboelastometry and Conventional Fibrinolysis Markers

Clinical and Applied Thrombosis/Hemostasis, 2020
The association between severity of fibrinolysis, ascertained by rotational thromboelastometry to diagnose hyperfibrinolysis in patients with out-of-hospital cardiac arrest (OHCA), and conventional fibrinolysis markers (ie, tissue-plasminogen activator ...
Tomoyo Saito MD, PhD, Mineji Hayakawa MD, PhD, Yoshinori Honma MD, Asumi Mizugaki MD, Tomonao Yoshida MD, Kenichi Katabami MD, Takeshi Wada MD, PhD, Kunihiko Maekawa MD   +7 more
doaj   +2 more sources

What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies

Blood Coagulation and Fibrinolysis, 2019
&NA; Intravenous tranexamic acid (TXA) reduces death because of bleeding in patients with trauma and postpartum haemorrhage. However, in some settings intravenous injection is not feasible.
R. Picetti, H. Shakur-Still, R. Medcalf, J. Standing, I. Roberts   +4 more
semanticscholar   +1 more source

Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity

Journal of Clinical Investigation, 2020
Fibrinolysis is initiated by tissue-type plasminogen activator (tPA) and inhibited by plasminogen activator inhibitor 1 (PAI-1). In obese humans, plasma PAI-1 and tPA proteins are increased, but PAI-1 dominates, leading to reduced fibrinolysis and ...
Ze Zheng, Keiko Nakamura, Shana Gershbaum, Xiaobo Wang, S. Thomas, M. Bessler, B. Schrope, Abraham Krikhely, Rui‐Ming Liu, L. Ozcan, José A López, I. Tabas   +11 more
semanticscholar   +1 more source

Angiographic outcomes in STEMI patients receiving fibrinolysis with guideline directed optimal antithrombotic therapy

Indian Heart Journal, 2021
STEMI is a major public health problem requiring timely reperfusion. Fibrinolysis remains prevalent reperfusion strategy where timely primary percutaneous coronary intervention (PCI) cannot be performed.
Shazia Durdana, Mohammad Azharuddin Malik, Asif Hasan, M.U. Rabbani   +3 more
doaj   +1 more source

Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications.

Anesthesia and Analgesia, 2019
Despite over a half-century of recognizing fibrinolytic abnormalities after trauma, we remain in our infancy in understanding the underlying mechanisms causing these changes, resulting in ineffective treatment strategies.
H. Moore, E. Moore, M. Neal, F. Sheppard, L. Kornblith, D. Draxler, M. Walsh, R. Medcalf, Mitch J. Cohen, B. Cotton, S. Thomas, Christine M. Leeper, B. Gaines, A. Sauaia   +13 more
semanticscholar   +1 more source

A novel serine protease secreted by medicinal maggots enhances plasminogen activator-induced fibrinolysis. [PDF]

PLoS ONE, 2014
Maggots of the blowfly Lucilia sericata are used for the treatment of chronic wounds. As haemostatic processes play an important role in wound healing, this study focused on the effects of maggot secretions on coagulation and fibrinolysis.
Mariena J A van der Plas, Anders S Andersen, Sheresma Nazir, Nico H van Tilburg, Peter R Oestergaard, Karen A Krogfelt, Jaap T van Dissel, Paul J Hensbergen, Rogier M Bertina, Peter H Nibbering   +9 more
doaj   +1 more source

Thrombin activatable fibrinolysis inhibitor como preditor de sangramento no transplante hepático: estudo piloto observacional

Revista Brasileira de Terapia Intensiva
RESUMO Objetivo: Correlacionar os níveis de thrombin activatable fibrinolysis inhibitor no pós-operatório imediato e com 24 horas de pós-operatório com o volume de sangramento tansoperatório.
Wagner Luis Nedel, Edison Moraes Rodrigues Filho, Alessandro Comarú Pasqualotto   +2 more
doaj   +1 more source

Hyperfibrinolysis and fibrinolysis shutdown in patients with traumatic brain injury

Scientific Reports, 2022
Traumatic brain injury (TBI) is associated with coagulation/fibrinolysis disorders. We retrospectively evaluated 61 TBI cases transported to hospital within 1 h post-injury.
Ryuta Nakae, Yasuo Murai, Takeshi Wada, Yu Fujiki, Takahiro Kanaya, Yasuhiro Takayama, Go Suzuki, Yasutaka Naoe, Hiroyuki Yokota, Shoji Yokobori   +9 more
doaj   +1 more source

Halo fluorescence fibrinolysis test: a novel quantitative assay to evaluate fibrinolysis on established plasma clots

Research and Practice in Thrombosis and Haemostasis
Background: Fibrinolysis is essential for dissolving blood clots and maintaining hemostasis. This process is primarily mediated by tissue-type plasminogen activator, which converts plasminogen into plasmin, thereby breaking down fibrin clots. Traditional
Zikou Liu, Orr Zaacks, Be’eri Niego, Robert L. Medcalf   +3 more
doaj   +1 more source

Temporal Trends in Care and Outcomes of Patients Receiving Fibrinolytic Therapy Compared to Primary Percutaneous Coronary Intervention: Insights From the Get With The Guidelines Coronary Artery Disease (GWTG‐CAD) Registry

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundTimely reperfusion after ST‐elevation myocardial infarction (STEMI) improves survival. Guidelines recommend primary percutaneous coronary intervention (PPCI) within 90 minutes of arrival at a PCI‐capable hospital.
Ravi S. Hira, Deepak L. Bhatt, Gregg C. Fonarow, Paul A. Heidenreich, Christine Ju, Salim S. Virani, Biykem Bozkurt, Laura A. Petersen, Adrian F. Hernandez, Lee H. Schwamm, Zubin J. Eapen, Michelle A. Albert, Li Liang, Roland A. Matsouaka, Eric D. Peterson, Hani Jneid   +15 more
doaj   +1 more source