Results 21 to 30 of about 47,940 (267)

Fibrinolysis Shutdown Correlation with Thromboembolic Events in Severe COVID-19 Infection

Journal of the American College of Surgeons, 2020
Background COVID-19 predisposes patients to a prothrombotic state with demonstrated microvascular involvement. The degree of hypercoagulability appears to correlate with outcomes; however, optimal criteria to assess for the highest-risk patients for ...
F. Wright, T. Vogler, E. Moore, H. Moore, M. Wohlauer, Shane Urban, T. Nydam, Peter K. Moore, R. McIntyre   +8 more
semanticscholar   +1 more source

Fibrinolysis in platelet thrombi [PDF]

, 2021
The extent and duration of occlusive thrombus formation following an arterial athero-thrombotic plaque disruption may be determined by the effectiveness of endogenous fibrinolysis.
Diana A. Gorog, Kanji, Rahim, Gue, Ying X., Memtsas, Vassilios, Kanji, R, Ying X. Gue, Rahim Kanji, Vassilios Memtsas, Gorog, Diana, Memtsas, V, Gorog, DA, Gue, YX   +11 more
core   +1 more source

Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients.

PLoS ONE, 2021
BackgroundThe effect of alcohol on the outcome and fibrinolysis phenotype in trauma patients remains unclear. Hence, we performed this study to determine whether alcohol is a risk factor for mortality and fibrinolysis shutdown in trauma patients ...
Il-Jae Wang, Byung-Kwan Bae, Young Mo Cho, Suck Ju Cho, Seok-Ran Yeom, Sang-Bong Lee, Mose Chun, Hyerim Kim, Hyung-Hoi Kim, Sun Min Lee, Up Huh, Soo Young Moon   +11 more
doaj   +1 more source

Disorders of fibrinogen and fibrinolysis

Hematology/Oncology Clinics of North America, 2021
Fibrinogen plays a fundamental role in coagulation through its support for platelet aggregation and its conversion to fibrin. Fibrin stabilizes clots and serves as a scaffold and immune effector before being broken down by the fibrinolytic system.
Jori E. May, A. Wolberg, Ming Y. Lim
semanticscholar   +1 more source

Fibrinolytic therapy use for ST-segment elevation myocardial infarction and long-term outcomes in China: 2-year results from the China Acute Myocardial Infarction Registry

BMC Cardiovascular Disorders, 2023
Background Data on fibrinolytic therapy use for ST-segment elevation myocardial infarction (STEMI) and long-term clinical outcomes in developing countries are limited.
Chao Wu, Ling Li, Shuqing Wang, Jianping Zeng, Jingang Yang, Haiyan Xu, Yanyan Zhao, Yang Wang, Wei Li, Chen Jin, Xiaojin Gao, Yuejin Yang, Shubin Qiao   +12 more
doaj   +1 more source

Global coagulation assays to measure in vitro fibrinolysis

Thrombosis Update, 2021
(249/250 words): Introduction: Fibrinolysis is a critical component of hemostasis associated with poor outcomes if not treated early and effectively. Successful hemostasis management requires close fibrinolysis monitoring. The study aimed to compare the
Joao D. Dias, Ebrahim Shafizadeh, Jamie Leiriao, Jan Hartmann   +3 more
doaj   +1 more source

uPA-mediated plasminogen activation is enhanced by polyphosphate

Haematologica, 2020
Tissue plasminogen activator (tPA) and urokinase (uPA) differ in their modes of action. Efficient tPA-mediated plasminogen activation requires binding to fibrin.
Claire S. Whyte, Nicola J. Mutch
doaj   +1 more source

Impaired fibrinolysis in critically ill COVID-19 patients

British Journal of Anaesthesia, 2020
Background Critically ill coronavirus disease 2019 (COVID-19) patients present with a hypercoagulable state with high rates of macrovascular and microvascular thrombosis, for which hypofibrinolysis might be an important contributing factor.
M. Bachler, Johannes Bösch, Daniel P. Stürzel, T. Hell, A. Giebl, M. Ströhle, S. Klein, Volker Schäfer, G. Lehner, M. Joannidis, C. Thomé, D. Fries   +11 more
semanticscholar   +1 more source

Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study

Critical Care, 2023
Background Fibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g.
Lucy A. Coupland, David J. Rabbolini, Jonathan G. Schoenecker, Philip J. Crispin, Jennene J. Miller, Tony Ghent, Robert L. Medcalf, Anders E. Aneman   +7 more
doaj   +1 more source

Annexin A2 in Fibrinolysis, Inflammation and Fibrosis

International Journal of Molecular Sciences, 2021
As a cell surface tissue plasminogen activator (tPA)-plasminogen receptor, the annexin A2 (A2) complex facilitates plasmin generation on the endothelial cell surface, and is an established regulator of hemostasis.
Hana I Lim, K. Hajjar
semanticscholar   +1 more source