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FIBRINOLYSIS: MODERN VIEW, PATHOLOGY, DIAGNOSTICS

Байкальский медицинский журнал
Relevance. Fibrinolysis is an important and integral part of the hemostasis system. Acting in parallel and together, the blood coagulation and fibrinolysis systems protect the body from excessive thrombus formation and vascular occlusion, on the one hand,
Lyudmila O. Gutsol, Irina E. Egorova, Igor Zh. Seminsky, Evgenia V. Guzovskaiia, Svetlana N. Serebrennikova, Lyudmila A. Dmitrieva   +5 more
doaj   +2 more sources

Relationship Between Severity of Fibrinolysis Based on Rotational Thromboelastometry and Conventional Fibrinolysis Markers

Clinical and Applied Thrombosis/Hemostasis, 2020
The association between severity of fibrinolysis, ascertained by rotational thromboelastometry to diagnose hyperfibrinolysis in patients with out-of-hospital cardiac arrest (OHCA), and conventional fibrinolysis markers (ie, tissue-plasminogen activator ...
Tomoyo Saito MD, PhD, Mineji Hayakawa MD, PhD, Yoshinori Honma MD, Asumi Mizugaki MD, Tomonao Yoshida MD, Kenichi Katabami MD, Takeshi Wada MD, PhD, Kunihiko Maekawa MD   +7 more
doaj   +2 more sources

Fibrinolysis in platelet thrombi [PDF]

, 2021
The extent and duration of occlusive thrombus formation following an arterial athero-thrombotic plaque disruption may be determined by the effectiveness of endogenous fibrinolysis.
Diana A. Gorog, Kanji, Rahim, Gue, Ying X., Memtsas, Vassilios, Kanji, R, Ying X. Gue, Rahim Kanji, Vassilios Memtsas, Gorog, Diana, Memtsas, V, Gorog, DA, Gue, YX   +11 more
core   +1 more source

The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome [PDF]

, 2002
In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation
Cate, Hugo ten, Djokomoeljanto, Robert J., Gorp , Eric C.M. van, Dolmans, Wil M.V., Hack, C. Erik, Suharti, Catharina, Meer, Jos W.M. van der, Setiati , Tatty E.   +7 more
core   +2 more sources

uPA-mediated plasminogen activation is enhanced by polyphosphate

Haematologica, 2020
Tissue plasminogen activator (tPA) and urokinase (uPA) differ in their modes of action. Efficient tPA-mediated plasminogen activation requires binding to fibrin.
Claire S. Whyte, Nicola J. Mutch
doaj   +1 more source

Investigation of the Relationship Between TAFI Plasma Levels and Hemorrhage in Patients with Crimean-Congo Hemorrhagic Fever and the Role of TAFI in the Disease Pathogenesis

Cerrahpaşa Medical Journal, 2021
Objective: Crimean-Congo hemorrhagic fever is a tick-borne viral infection presenting with fever and bleeding. Thrombin-activatable fibrinolysis inhibitor is a plasma procarboxypeptidase synthesized in the liver, causing downregulation of fibrinolysis ...
Hüsna Şengül Aşkın, Mehmet Parlak, Esra Laloğlu, Sinan Yılmaz, Lütfü Aşkın, Emine Parlak   +5 more
doaj   +1 more source

Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study

Critical Care, 2023
Background Fibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g.
Lucy A. Coupland, David J. Rabbolini, Jonathan G. Schoenecker, Philip J. Crispin, Jennene J. Miller, Tony Ghent, Robert L. Medcalf, Anders E. Aneman   +7 more
doaj   +1 more source

The state of the fibrinolytic system in HIV-infected pregnant women and parturient women with thrombohemorrhagic risk factors

Репродуктивная эндокринология, 2020
Purpose of the study: to explore the status of the fibrinolytic system in HIV-infected pregnant women and parturient women. Materials and methods. 120 HIV-positive pregnant women with risk factors of thrombohemorrhagic complications were examined.
С. Є. Савченко, О. І. Гервазюк, Л. М. Онищик, Ю. С. Мудра, Г. Б. Бойко   +4 more
doaj   +1 more source

Microparticles and Fibrinolysis [PDF]

Seminars in Thrombosis and Hemostasis, 2016
Microparticles (MPs) are submicronic vesicles which are formed by budding of the cellular membrane of virtually any cell type in response to cell activation or apoptosis. Both circulating MPs and MPs generated within tissues harbor molecules with a large repertoire of biological activities and transfer material to target cells.
Vallier, Loris, Cointe, Sylvie, Lacroix, Romaric, Bonifay, Amandine, Judicone, Coralie, Dignat-George, Francoise, Kwaan, Hau C   +6 more
openaire   +2 more sources

Increased thrombin activatable fibrinolysis inhibitor activity is associated with hypofibrinolysis in dogs with sepsis

Frontiers in Veterinary Science, 2023
IntroductionDisorders of coagulation are well-recognized in dogs with sepsis, but data regarding fibrinolysis disorders are limited. We aimed to characterize fibrinolysis in dogs with sepsis compared to healthy controls.
Katherine E. Sotos, Robert Goggs, Alyssa P. Stablein, Marjory B. Brooks   +3 more
doaj   +1 more source