Results 1 to 10 of about 136,149 (288)

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

The C-Terminal Domain of Staphylococcus aureus Zinc Transport Protein AdcA Binds Plasminogen and Factor H In Vitro

Pathogens, 2022
Bacterial acquisition of metals from a host is an essential attribute to facilitate survival and colonization within an infected organism. Staphylococcus aureus, a bacterial pathogen of medical importance, has evolved its strategies to acquire multiple ...
Natália Salazar, Bruno Bernardi Yamamoto, Matilde Costa Lima de Souza, Ludmila Bezerra da Silva, Ana Paula Mattos Arêas, Angela Silva Barbosa   +5 more
doaj   +1 more source

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]

, 2013
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Emiri Mandeville, Cianchetti, Flor A., Ken Arai, van Leyen, Klaus, Frieder Schlunk (280822), Eng H. Lo (112154), Kazim Yigitkanli, Chris B Schaffer, Mandeville, Emiri, Yigitkanli, Kazim, Xiaoying Wang, Nathanael L Rosidi, Chris B. Schaffer (155846), Arne Lauer (280824), Fan, Xiang, Eng H Lo, Helmuth Steinmetz (149409), Rosidi, Nathanael L., Xiang Fan (280830), Schlunk, Frieder, Frieder Schlunk, Flor A. Cianchetti (280825), Wang, Xiaoying, Christian Foerch (149410), Flor A Cianchetti, Kazim Yigitkanli (280829), Arai, Ken, Förch, Christian, Leyen, Klaus van, Lo, Eng H., Foerch, Christian, Xiang Fan, Schaffer, Chris B., Ken Arai (280828), Klaus van Leyen, Helmuth Steinmetz, Emiri Mandeville (280827), Steinmetz, Helmuth, Christian Foerch, Lo, Eng, Arne Lauer, Nathanael L. Rosidi (280821), Xiaoying Wang (30853), Klaus van Leyen (280831), Lauer, Arne   +44 more
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Heat-Treatments Affect Protease Activities and Peptide Profiles of Ruminants' Milk

Frontiers in Nutrition, 2021
Proteases present in milk are heat-sensitive, and their activities increase or decrease depending on the intensity of the thermal treatment applied. The thermal effects on the protease activity are well-known for bovine milk but poorly understood for ...
Juliana A. S. Leite, Carlos A. Montoya, Carlos A. Montoya, Simon M. Loveday, Simon M. Loveday, Evelyne Maes, Jane A. Mullaney, Jane A. Mullaney, Jane A. Mullaney, Warren C. McNabb, Warren C. McNabb, Nicole C. Roy, Nicole C. Roy, Nicole C. Roy, Nicole C. Roy   +14 more
doaj   +1 more source

Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoter polymorphism [PDF]

, 2005
Background: Dengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is associated with increased PAI-1 ...
ten Cate, H, Brandjes, DPM, Mairuhu, A. T. A., Hack, C. E., Leyte, A, Osterhaus, A.D.M.E. (Albert), Koraka, P. (Penelope), Brandjes, D.P.M. (Dees), Mairuhu, A.T., ten Cate H, Brandjes, D.P., SMH Faradz, Faradz, S.M.H., van Gorp, E., Hack, C. Erik, Setiati, T., Brandjes DPM, Mairuhu, ATA, Osterhaus ADME, Setiati, T. E., Reitsma, PH, Osterhaus, A.D.M.E., Faradz, SMH, Faradz SMH, Gorp, E. van, Brandjes, D. P. M., van Gorp, E. C. M., Faradz, Sultana M.H., Setiati, T.E. (Tatty), Brandjes, D.P.M., Osterhaus, A.D., Setiati, Tatty E., van Gorp, E.C.M., Cate, H. (Hugo) ten, Koraka, P., Reitsma PH, van Gorp, Eric, Mairuhu, A.T.A., Mairuhu ATA, Reitsma, P., ECM van Gorp, Koraka, Penelopie, Reitsma, P.H., A Leyte, Setiati, TE, van Gorp, Eric C. M., Setiati TE, Osterhaus, Ab, Koraka, P, Leyte A, H ten Cate, ADME Osterhaus, Osterhaus, A. D. M. E., Hack CE, PH Reitsma, Setiati, T.E., Hack, C.E., Osterhaus, ADME, Faradz, S. M. H., CE Hack, Reitsma, P. H., van Gorp ECM, ATA Mairuhu, Osterhaus, A., TE Setiati, Koraka P, Leyte, A. (Anja), P Koraka, Mairuhu, A., Faradz, S.M.H. (Sultana), Gorp, E.C.M. (Eric) van, Hack, CE, DPM Brandjes, Hack, C., Faradz, S., Cate, H. Ten, Hack, C.E. (Erik), ten Cate, H., Leyte, A.   +78 more
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S100A10, a novel biomarker in pancreatic ductal adenocarcinoma

Molecular Oncology, 2018
Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome.
Moamen Bydoun, Andra Sterea, Henry Liptay, Andrea Uzans, Weei‐Yuarn Huang, Gloria J. Rodrigues, Ian C.G. Weaver, Hong Gu, David M. Waisman   +8 more
doaj   +1 more source

Biopharmaceutical Assessment of Mesh Aerosolised Plasminogen, a Step towards ARDS Treatment

Pharmaceutics, 2023
Acute respiratory distress syndrome (ARDS) is a severe complication of lung injuries, commonly associated with bacterial, fungal and viral infections, including SARS-CoV-2 viral infections.
Lucia Vizzoni, Chiara Migone, Brunella Grassiri, Ylenia Zambito, Baldassare Ferro, Paolo Roncucci, Filippo Mori, Alfonso Salvatore, Ester Ascione, Roberto Crea, Semih Esin, Giovanna Batoni, Anna Maria Piras   +12 more
doaj   +1 more source

Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II trials [PDF]

, 2009
<p><b>Background and Purpose:</b> A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies.</p> <p><b>Methods:</b> We examined patients with
Demchuk, A., Lees, K.R., Kasner, S.E., Messe, S.R., Cucchiara, B., Levine, S.R., Lyden, P., Sansing, L., Tanne, D.   +8 more
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In vitro influence on fibrinolysis parameters of aqueous extracts of mushrooms growing on woody plants

Разработка и регистрация лекарственных средств
Introduction. Various compounds of mushroom extracts are of interest as a source of new active pharmaceutical substances with antithrombotic activity.Aim.
N. M. Faustova, D. N. Vedernikov, V. V. Bakanov, E. N. Pavlova, E. N. Vlasova, Yu. A. Skorik   +5 more
doaj   +1 more source

Plasminogen activation in the musculoskeletal acute phase response: Injury, repair, and disease

Research and Practice in Thrombosis and Haemostasis, 2020
The musculoskeletal system is critical for movement and the protection of organs. In addition to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated process of repair referred to as the acute‐phase response (APR ...
Breanne H.Y. Gibson, Matthew T. Duvernay, Stephanie N. Moore‐Lotridge, Matthew J. Flick, Jonathan G. Schoenecker   +4 more
doaj   +1 more source