Results 1 to 10 of about 45,087 (118)

Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor

Cell Reports, 2022
Summary: Enolase is a highly conserved enzyme that presents in all organisms capable of glycolysis or fermentation. Its immediate product phosphoenolpyruvate is essential for other important processes like peptidoglycan synthesis and the ...
Sivaramesh Wigneshweraraj, Shanshan Li, Kaiming Zhang   +2 more
exaly   +3 more sources

Giardiavirus rewires host translation and glycolytic metabolism to support its replication in <i>Giardia duodenalis</i>. [PDF]

Virulence
Giardia duodenalis is an intestinal protozoan parasite responsible for giardiasis, a disease primarily characterized by diarrhea and associated with long-term complications such as malnutrition and growth impairment in children.
Li L, Cao L, Zhong C, Zhang N, Li X, Wang X, Guo Y, Yu Y, Li J, Zhang X, Le Y, Yuan J, Gong P.   +12 more
europepmc   +2 more sources

Enolase of Staphylococcus lugdunensis Is a Surface-Exposed Moonlighting Protein That Binds to Extracellular Matrix and the Plasminogen/Plasmin System

Frontiers in Microbiology, 2022
The coagulase-negative staphylococcal (CoNS) species Staphylococcus lugdunensis is unique in causing serious infections in humans that resemble those of Staphylococcus aureus rather than those of other CoNS species.
Muzaffar Hussain, Christian Kohler, Karsten Becker, Karsten Becker, Karsten Becker   +4 more
doaj   +1 more source

Enolase Inhibitors as Early Lead Therapeutics against Trypanosoma brucei

Pathogens, 2023
Glucose metabolism is critical for the African trypanosome, Trypanosoma brucei, serving as the lone source of ATP production for the bloodstream form (BSF) parasite in the glucose-rich environment of the host blood.
Colm P. Roster, Danielle LaVigne, Jillian E. Milanes, Emily Knight, Heidi D. Anderson, Sabrina Pizarro, Elijah M. Harding, Meredith T. Morris, Victoria C. Yan, Cong-Dat Pham, Florian Muller, Samuel Kwain, Kerrick C. Rees, Brian Dominy, Daniel C. Whitehead, Md Nasir Uddin, Steven W. Millward, James C. Morris   +17 more
doaj   +1 more source

The History of Anti-Trypanosome Vaccine Development Shows That Highly Immunogenic and Exposed Pathogen-Derived Antigens Are Not Necessarily Good Target Candidates: Enolase and ISG75 as Examples

Pathogens, 2021
Salivarian trypanosomes comprise a group of extracellular anthroponotic and zoonotic parasites. The only sustainable method for global control of these infection is through vaccination of livestock animals.
Stefan Magez, Zeng Li, Hang Thi Thu Nguyen, Joar Esteban Pinto Torres, Pieter Van Wielendaele, Magdalena Radwanska, Jakub Began, Sebastian Zoll, Yann G.-J. Sterckx   +8 more
doaj   +1 more source

Giardia duodenalis enolase is secreted as monomer during trophozoite-epithelial cell interactions, activates plasminogen and induces necroptotic damage

Frontiers in Cellular and Infection Microbiology, 2022
Enolase, a multifunctional protein expressed by multiple pathogens activates plasminogen to promote proteolysis on components of the extracellular matrix, an important event in early host-pathogen interactions. A secreted form of enolase that is released
Elisa Barroeta-Echegaray, Rocío Fonseca-Liñán, Raúl Argüello-García, Rafael Rodríguez-Muñoz, Rosa María Bermúdez-Cruz, Porfirio Nava, M. Guadalupe Ortega-Pierres   +6 more
doaj   +1 more source

Moonlighting in Bacillus subtilis: The Small Proteins SR1P and SR7P Regulate the Moonlighting Activity of Glyceraldehyde 3-Phosphate Dehydrogenase A (GapA) and Enolase in RNA Degradation

Microorganisms, 2021
Moonlighting proteins are proteins with more than one function. During the past 25 years, they have been found to be rather widespread in bacteria. In Bacillus subtilis, moonlighting has been disclosed to occur via DNA, protein or RNA binding or protein ...
Inam Ul Haq, Sabine Brantl
doaj   +1 more source

A proteomic analysis of the functional effects of fatty acids in NIH 3T3 fibroblasts

Lipids in Health and Disease, 2011
Previous studies have demonstrated that long chain fatty acids influence fibroblast function at sub-lethal concentrations. This study is the first to assess the effects of oleic, linoleic or palmitic acids on protein expression of fibroblasts, as ...
Magdalon Juliana, Hatanaka Elaine, Romanatto Talita, Rodrigues Hosana G, Kuwabara Wilson MT, Scaife Caitriona, Newsholme Philip, Curi Rui   +7 more
doaj   +1 more source

Pangenomics Analysis Reveals Diversification of Enzyme Families and Niche Specialization in Globally Abundant SAR202 Bacteria

mBio, 2020
It has been hypothesized that the abundant heterotrophic ocean bacterioplankton in the SAR202 clade of the phylum Chloroflexi evolved specialized metabolisms for the oxidation of organic compounds that are resistant to microbial degradation via common ...
Jimmy H. W. Saw, Takuro Nunoura, Miho Hirai, Yoshihiro Takaki, Rachel Parsons, Michelle Michelsen, Krista Longnecker, Elizabeth B. Kujawinski, Ramunas Stepanauskas, Zachary Landry, Craig A. Carlson, Stephen J. Giovannoni   +11 more
doaj   +1 more source

Extracellular enolase of Candida albicans is involved in colonization of mammalian intestinal epithelium

Frontiers in Cellular and Infection Microbiology, 2014
Enolase is secreted by C. albicans and is present in its biofilms although its extracellular function is unknown. Here we show that extracellular enolase mediates the colonization of small intestine mucosa by C. albicans.
Richard Cardoso Silva, Ana Carolina Barbosa Padovan, Daniel C Pimenta, Renata Carmona Ferreira, Claudio Vieira Silva, Marcelo R. S. Briones   +5 more
doaj   +1 more source