Modulation of neuronal plasticity by extracellular serine proteases and their inhibitors : proteolytic control of NMDA receptors [PDF]
, 2004 Serine proteases are enzymes catalyzing protein cleavage. Because of their capability to cleave a wide variety of substrates, they are involved in many critical physiological processes such as digestion, hemostasis, reproduction and immune response, as ...
Kvajo, Mirna
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Preventing Candida albicans from subverting host plasminogen for invasive infection treatment
Emerging Microbes and Infections, 2020 Candida albicans is a common fungal pathogen in humans that colonizes the skin and mucosal surfaces of the majority healthy individuals. How C.
Si-Min Chen +10 more
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Proteolyzed Variant of IgG with Free C-Terminal Lysine as a Biomarker of Prostate Cancer
Biology, 2021 The differential diagnosis of prostate cancer is problematic due to the lack of markers with high diagnostic accuracy. We previously demonstrated the increased binding of IgG to human plasminogen (PLG) in plasma of patients with prostate cancer (PC ...
Anna Lokshin +10 more
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Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]
, 2009 Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie +26 more
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Laureates of the Palladin Prize of the National Academy of Sciences of Ukraine (1985–1986) [PDF]
The Ukrainian Biochemical Journal, 2013 The article presents the information about the life and scientific activity of the Palladin Prize laureats. In 1985, S. O. Kudinov was awarded the Prize for his monograph ”Ca2+ transport systems in nerve cells”. In 1986, A. Ya. Rozanov, A.
R. P. Vynogradova, V. M. Danilova
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Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]
, 2003 Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito +6 more
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Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]
, 2013 Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Emiri Mandeville +44 more
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Pathogens, 2022 Bacterial acquisition of metals from a host is an essential attribute to facilitate survival and colonization within an infected organism. Staphylococcus aureus, a bacterial pathogen of medical importance, has evolved its strategies to acquire multiple ...
Natália Salazar +5 more
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Human plasma-derived plasminogen replacement in type 1 plasminogen deficiency: a pediatric case with multisystemic manifestation [PDF]
The article by D€onmez-Demir et al., ‘Novel plasminogen gene mutations in Turkish patients with type I plasminogen deficiency’, recently published in Blood Coagulation and Fibrinolysis[1], was read with great interest. The study’s authors expanded the
Ünal, Ekrem +6 more
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L-mimosine and dimethyloxaloylglycine decrease plasminogen activation in periodontal fibroblasts [PDF]
, 2014 BACKGROUND The use of prolyl hydroxylase inhibitors such as l-mimosine (L-MIM) and dimethyloxaloylglycine (DMOG) to improve angiogenesis is a new approach for periodontal regeneration.
Gruber, Reinhard +5 more
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