Results 41 to 50 of about 136,149 (288)

Hemostasis System and Plasminogen Activity in Retrochorial Hematoma in the First Trimester of Pregnancy

Biomedicines, 2022
(1) Background: The components of the fibrinolytic system and its main component, plasminogen, play a key role in the first months of pregnancy. The effect of autoantibodies interacting with plasminogen in the formation of retrochorial hematoma is ...
Natalia B. Tikhonova, Natalya B. Kuznetsova, Andrey P. Milovanov, Eugene I. Goufman, Tatiana V. Fokina, Andrey P. Aleksankin, Valentina V. Aleksankina, Irina I. Stepanova, Alexandr A. Stepanov, Marina N. Boltovskaya, Natalia V. Nizyaeva   +10 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Histone 2B Facilitates Plasminogen-Enhanced Endothelial Migration through Protease-Activated Receptor 1 (PAR1) and Protease-Activated Receptor 2 (PAR2)

Biomolecules, 2022
Plasminogen and its multiple receptors have been implicated in the responses of many different cell types. Among these receptors, histone 2B (H2B) has been shown to play a prominent role in macrophage responses.
Mitali Das, Sujay Subbayya Ithychanda, Edward F. Plow   +2 more
doaj   +1 more source

Contribution of Streptokinase-Domains from Groups G and A (SK2a) Streptococci in Amidolytic /Proteolytic Activities and Fibrin-Dependent Plasminogen Activation: A Domain-Exchange Study [PDF]

Iranian Biomedical Journal, 2020
Background: SK, a heterogeneous PA protein from groups A, C, and G streptococci (GAS, GCS, GGS, respectively) contains three structural domains (SKα, SKβ, and SK).
Maryam Rafipour, Malihe Keramati, Mohammad Mehdi Aslani, Arash Arashkia, Farzin Roohvand   +4 more
doaj   +1 more source

Plasminogen-derived peptide promotes adipogenic differentiation of preadipocytes in vitro and in vivo

, 2022
Soft tissue defects caused by adipose tissue loss can result in various conditions such as lipodystrophy in congenital diseases, trauma secondary to aging, and mastectomy in breast cancer; fat grafting is commonly performed to restore these defects ...
Jong-Ho Kim (317877), Jung Hee Shim (14138239), Chan Yeong Heo (5243945), Hea Jung Yang (14138236)   +3 more
core   +1 more source

Serum Proteomic Profile of Asthmatic Patients after Six Months of Benralizumab and Mepolizumab Treatment

Biomedicines, 2022
Severe eosinophilic asthma is characterized by chronic airway inflammation, oxidative stress, and elevated proinflammatory cytokines, especially IL-5.
Lorenza Vantaggiato, Paolo Cameli, Laura Bergantini, Miriana d’Alessandro, Enxhi Shaba, Alfonso Carleo, Fabrizio Di Giuseppe, Stefania Angelucci, Guido Sebastiani, Francesco Dotta, Luca Bini, Elena Bargagli, Claudia Landi   +12 more
doaj   +1 more source

Impaired Fibrinolysis in the Pathogenesis of Dengue Hemorrhagic Fever [PDF]

, 2002
The mechanisms contributing to bleeding complications in dengue hemorrhagic fever were studied by investigating the pattern of activation of the coagulation and fibrinolytic systems in 50 children with severe dengue hemorrhagic fever.
Eric C.M. van Gorp, ten Cate, H, Brandjes, DPM, Wil M.V. Dolmans, van der Meer, Jos W. M., Mairuhu, Albert T. A., Cate Ht, Hugo ten, Mairuhu, A.T., Brandjes, D.P., Cate, H.H., Setiati, T.E., Dolmans, W.M.V., Jos W.M. van der Meer, Hugo ten Cate, Hack, C. Erik, Hack, C.E., Mairuhu, ATA, Cate, H. ten, C. Erik Hack, Suharti, C., Catharina Suharti, Gorp, E. van, Brandjes, D.P.M., Albert T.A. Mairuhu, Dolmans, Wil M. V., Meer, J.W.M. van der, Setiati, Tatty E., Mairuhu, A.T.A., Tatty E. Setiati, Suharti, Catharina, Dees P.M. Brandjes, van Gorp, Eric C. M., Gorp, E.C.M. van, Brandjes, Dees P. M.   +33 more
core   +1 more source

The Pneumococcal Protein SufC Binds to Host Plasminogen and Promotes Its Conversion into Plasmin

Microorganisms, 2023
Streptococcus pneumoniae causes otitis media, sinusitis, and serious diseases such as pneumonia and bacteremia. However, the in vivo dynamics of S. pneumoniae infections and disease severity are not fully understood.
Yoshihito Yasui, Satoru Hirayama, Takumi Hiyoshi, Toshihito Isono, Hisanori Domon, Tomoki Maekawa, Koichi Tabeta, Yutaka Terao   +7 more
doaj   +1 more source

Glu- and Lys-forms of plasminogen differentially affect phosphatidylserine exposure on the platelet surface [PDF]

, 2017
Plasminogen/plasmin system is known for its ability to support hemostatic balance of blood. However, plasminogen may be considered as an adhesive ligand and in this way could affect the functioning of blood cells. We showed that exogenous Lys-plasminogen,
Zhernossekov, D.D., T. V. Grinenko, D. D. Zhernossekov, M. M. Guzyk, A. O. Tykhomyrov, Roka-Moiia, Y.M., Guzyk, M.M., Y. M. Roka-Moiia, Grinenko, T.V., Tykhomyrov, A.O.   +9 more
core   +1 more source

t-PA Suppresses the Immune Response and Aggravates Neurological Deficit in a Murine Model of Ischemic Stroke

Frontiers in Immunology, 2019
Introduction: Acute ischemic stroke (AIS) is a potent trigger of immunosuppression, resulting in increased infection risk. While thrombolytic therapy with tissue-type plasminogen activator (t-PA) is still the only pharmacological treatment for AIS ...
Dominik F. Draxler, Felix Lee, Heidi Ho, Charithani B. Keragala, Robert L. Medcalf, Be'eri Niego   +5 more
doaj   +1 more source