Results 51 to 60 of about 151,729 (305)

In vitro influence on fibrinolysis parameters of aqueous extracts of mushrooms growing on woody plants

Разработка и регистрация лекарственных средств
Introduction. Various compounds of mushroom extracts are of interest as a source of new active pharmaceutical substances with antithrombotic activity.Aim.
N. M. Faustova, D. N. Vedernikov, V. V. Bakanov, E. N. Pavlova, E. N. Vlasova, Yu. A. Skorik   +5 more
doaj   +1 more source

Biopharmaceutical Assessment of Mesh Aerosolised Plasminogen, a Step towards ARDS Treatment

Pharmaceutics, 2023
Acute respiratory distress syndrome (ARDS) is a severe complication of lung injuries, commonly associated with bacterial, fungal and viral infections, including SARS-CoV-2 viral infections.
Lucia Vizzoni, Chiara Migone, Brunella Grassiri, Ylenia Zambito, Baldassare Ferro, Paolo Roncucci, Filippo Mori, Alfonso Salvatore, Ester Ascione, Roberto Crea, Semih Esin, Giovanna Batoni, Anna Maria Piras   +12 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Cholera Vibrio Membrane Protein OmpT as an Omptin Belonging to Vibrionaceae Family

Проблемы особо опасных инфекций, 2014
Concerned are the issues related to enterobacteria omptins, their structure and functionality, as well as alternative role in pathogenesis of the infections induced by them.
B. N. Mishan’Kin, O. V. Duvanova, L. V. Romanova, E. S. Shipko, A. S. Vodop’Yanov   +4 more
doaj   +1 more source

Plasminogen activation in the musculoskeletal acute phase response: Injury, repair, and disease

Research and Practice in Thrombosis and Haemostasis, 2020
The musculoskeletal system is critical for movement and the protection of organs. In addition to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated process of repair referred to as the acute‐phase response (APR ...
Breanne H.Y. Gibson, Matthew T. Duvernay, Stephanie N. Moore‐Lotridge, Matthew J. Flick, Jonathan G. Schoenecker   +4 more
doaj   +1 more source

Plasminogen-Loaded Fibrin Scaffold as Drug Delivery System for Wound Healing Applications

Pharmaceutics, 2022
Plasminogen is a protein involved in intravascular and extravascular fibrinolysis, as well as in wound healing, cell migration, tissue formation and angiogenesis.
Tamer Al Kayal, Marianna Buscemi, Aida Cavallo, Ilenia Foffa, Giorgio Soldani, Paola Losi   +5 more
doaj   +1 more source

Interaction of plasminogen and fibrin in plasminogen activation.

Journal of Biological Chemistry, 1990
Glu1-, Lys77-, miniplasminogens, kringle 1-3, kringle 1-5A, and kringle 1-5R were able to bind with fibrin, while microplasminogen and kringle 4 did not bind significantly. Kringle 1-5A, but not kringle 1-3, effectively inhibited the binding of Glu1-, Lys77-, and miniplasminogens with fibrin.
H L, Wu, B I, Chang, D H, Wu, L C, Chang, C C, Gong, K L, Lou, G Y, Shi   +6 more
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Plasminogen Assay

Clinical Chemistry, 1968
Abstract An indirect caseinolytic assay for plasminogen utilizing acid-treated plasma or serum and optimal concentrations of streptokinase is described. A linear response to increasing plasma or serum concentrations was observed. An acid-treated plasma or serum sample is preferable to euglobulin.
openaire   +2 more sources

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie, Sonja Grosskinsky, Markus M. Simon, Grosskinsky, Sonja, Cutler, Sally J., Schott, M., Simon, M., Kraiczy, P., Zipfel, Peter F., Grosskinsky, S., Peter Kraiczy, Sally J Cutler, Peter F Zipfel, Peter F. Zipfel, Brenner, Christiane, Wallich, R., Kraiczy, Peter, Brenner, C., Christiane Brenner, Simon, Markus M., Markus M Simon, Wallich, Reinhard, Sally J. Cutler, Reinhard Wallich, Cutler, S., Zipfel, P., Melanie Schott, Schott Melanie, Kraiczy Peter, Grosskinsky Sonja, Simon Markus M., Cutler Sally J., Zipfel Peter F., Brenner Christiane, Wallich Reinhard   +34 more
core   +2 more sources