Modulation of neuronal plasticity by extracellular serine proteases and their inhibitors : proteolytic control of NMDA receptors [PDF]
, 2004 Serine proteases are enzymes catalyzing protein cleavage. Because of their capability to cleave a wide variety of substrates, they are involved in many critical physiological processes such as digestion, hemostasis, reproduction and immune response, as ...
Kvajo, Mirna
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Кардиоваскулярная терапия и профилактика, 2011 Aim. To study the associations between polymorphic variants of hemostasis protein-coding genes, hemostasis system functioning, and atherothrombosis development in patients with cardiovascular disease (CVD). Material and methods.
G. I. Lifshits +4 more
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Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]
, 2009 Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie +26 more
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L-mimosine and dimethyloxaloylglycine decrease plasminogen activation in periodontal fibroblasts [PDF]
, 2014 BACKGROUND The use of prolyl hydroxylase inhibitors such as l-mimosine (L-MIM) and dimethyloxaloylglycine (DMOG) to improve angiogenesis is a new approach for periodontal regeneration.
Gruber, Reinhard +5 more
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Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]
, 2013 Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Emiri Mandeville +44 more
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Inhibition of thiol isomerase activity diminishes endothelial activation of plasminogen, but not of protein C [PDF]
, 2015 Highlights •A range of thiol isomerase enzymes were expressed by HMEC-1 endothelial cells. •Inhibition of thiol isomerases reduced plasminogen activation on HMEC-1 cells.
Smith, C.L. +3 more
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Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones [PDF]
, 2013 Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation,
Szabó, László +23 more
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Plasminogen and Plasminogen Activator Assembly on the Human Endothelial Cell
Experimental Biology and Medicine, 1993 Through assembly of plasminogen and its activators, the endothelial cell surface may provide a favorable environment for constitutive generation of plasmin. This system may be regulated at multiple levels. Abundant expression of a 40-kDa protein with dual ligand-binding capacity may promote cell surface plasmin formation by colocalizing t-PA and ...
G C, Shih, K A, Hajjar
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High resolution nuclear magnetic resonance studies of kringle containing proteins [PDF]
, 1983 The kringle is a name given to a sequence of seventy nine residues linked by three disulphide bridges, multiple copies of which have been found in a number of proteins involved in haemostasis.
Pluck, N. D. +2 more
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Frontiers in Veterinary Science, 2019 Babesia microti, an intraerythrocytic protozoa, can cause an emerging tick-borne disease—Human babesiosis. The parasite can successfully invade host red blood cells owing to the assistance of molecules expressed by babesia.
Xiangye Liu +8 more
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