Results 91 to 100 of about 136,538 (301)

Plasminogen and Plasminogen Activator Assembly on the Human Endothelial Cell

Experimental Biology and Medicine, 1993
Through assembly of plasminogen and its activators, the endothelial cell surface may provide a favorable environment for constitutive generation of plasmin. This system may be regulated at multiple levels. Abundant expression of a 40-kDa protein with dual ligand-binding capacity may promote cell surface plasmin formation by colocalizing t-PA and ...
G C, Shih, K A, Hajjar
openaire   +2 more sources

A processed Multidomain Mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia [PDF]

, 2010
Porcine enzootic pneumonia is a chronic respiratory disease that affects swine. The etiological agent of the disease, Mycoplasma hyopneumoniae, is a bacterium that adheres to cilia of the swine respiratory tract, resulting in loss of cilia and epithelial
Jenkins, Cheryl, Kuit, TA, Minion, F. Chris, Padula, M, Tracey A. Kuit, Falconer, Linda, Djordjevic, SP, Deutscher, AT, Deutscher, Ania T., Djordjevic, Steven P., Seymour, LM, Ben Crossett, Walker, Mark J., Matthew Padula, Jenkins, C, Mark J. Walker, Ania T. Deutscher, F. Chris Minion, Minion, FC, Steven P. Djordjevic, Falconer, L, Crossett, B, Padula, Matthew, Dixon, Nicholas E., Cheryl Jenkins, Crossett, Ben, Linda Falconer, Nicholas E. Dixon, Seymour, Lisa M., Walker, MJ, Kuit, Tracey A., Dixon, NE, Lisa M. Seymour   +32 more
core   +1 more source

Posthumously Diagnosed Myhre Syndrome Presenting With Pleural Remodeling and Endometrial Cancer

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (OMIM 139210) is a genetic condition defined by neurodevelopmental disability, characteristic facial features, and multisystem proliferative fibrosis. While various types of lung disease have been reported, pleural remodeling leading to restrictive lung disease has not yet been described.
Jeanette Saffir, Karee Morgan, Karigynn Chaimson, Blake E. Funke, Kim L. Sandler, Melissa Hogan, Thomas Cassini   +6 more
wiley   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Exposure of plasminogen and the novel plasminogen receptor, Plg-RKT, on activated human and murine platelets [PDF]

, 2020
Plasminogen activation rates are enhanced by cell surface binding. We have previously demonstrated that exogenous plasminogen binds to phosphatidylserine-exposing and spread platelets.
Miles, Lindsey A., Mutch, Nicola J., Mutch, Nicola J, Whyte, Claire S., Parmer, Robert J, Miles, Lindsey A, Booth, Nuala A., Jalal, Mohammed M, Whyte, Claire S, Jalal, Mohammed M., Morrow, Gael, Morrow, Gael B., Baik, Nagyung, Parmer, Robert J., Booth, Nuala A   +14 more
core   +2 more sources

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, EarlyView.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

Glyceraldehyde-3-Phosphate Dehydrogenase of Babesia microti Is a Plasminogen- and Actin-Binding Protein

Frontiers in Veterinary Science, 2019
Babesia microti, an intraerythrocytic protozoa, can cause an emerging tick-borne disease—Human babesiosis. The parasite can successfully invade host red blood cells owing to the assistance of molecules expressed by babesia.
Xiangye Liu, Huiqin Li, Hongkuan Deng, Chen Zheng, Hongru Yan, Zetian Chen, Anning Bian, Jiaxu Chen, Kuiyang Zheng   +8 more
doaj   +1 more source

Causal association of plasminogen activators and their inhibitors with Alzheimer’s disease: a Mendelian randomization study [PDF]

Introduction Alzheimer’s disease (AD) is the most common cause of dementia and contributes to a huge burden of disease worldwide. Observational studies have found that tissue plasminogen activator (t-PA) inhibits the development of AD, but little is ...
Xin Guo, Baolong Pan, Fangyu Gao, Jingsi Zhang, Feng Gao, Shanshan Wang, Qiao Niu   +6 more
core   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source

Trial of Amiloride in Type 2 Diabetes With Proteinuria

Kidney International Reports, 2017
Renal sodium (Na+) retention and extracellular fluid volume expansion are hallmarks of nephrotic syndrome, which occurs even in the absence of activation of hormones that stimulate renal Na+ transporters. Plasmin-dependent activation of the epithelial Na+
Mark L. Unruh, V. Shane Pankratz, John E. Demko, Evan C. Ray, Rebecca P. Hughey, Thomas R. Kleyman   +5 more
doaj   +1 more source