Results 81 to 90 of about 147,856 (201)

Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis [PDF]

, 2010
Background: Squamous cell carcinoma of the head and neck (SCCHN) are highly invasive tumours with frequent local and distant recurrence. Metastasis formation requires degradation of the extracellular matrix, which is fulfilled by membrane-associated ...
Olivier Gires, Muehlenweg Bernd, Pamela Zengel, Muehlenweg, Bernd, Gires, Olivier, Ramp, D., Gires, O., Alexander Berghaus, Gires Olivier, Mack, Brigitte, Zengel, Pamela, Zahler, Stefan, Muehlenweg, B., Diana Ramp, Stefan Zahler, Mack, B., Bernd Muehlenweg, Zahler, S., Berghaus Alexander, Mack Brigitte, Zengel, P., Suna Schmitz, Berghaus, Alexander, Schmitz, Suna, Schmitz, S., Ramp, Diana, Schmitz Suna, Zahler Stefan, Zengel Pamela, Brigitte Mack, Ramp Diana, Berghaus, A.   +31 more
core   +2 more sources

Trial of Amiloride in Type 2 Diabetes With Proteinuria

Kidney International Reports, 2017
Renal sodium (Na+) retention and extracellular fluid volume expansion are hallmarks of nephrotic syndrome, which occurs even in the absence of activation of hormones that stimulate renal Na+ transporters. Plasmin-dependent activation of the epithelial Na+
Mark L. Unruh, V. Shane Pankratz, John E. Demko, Evan C. Ray, Rebecca P. Hughey, Thomas R. Kleyman   +5 more
doaj   +1 more source

THE BIOLOGICAL AND CLINICAL IMPLICATIONS OF PLASMINOGEN ACTIVATION IN PANCREATIC AND LUNG CARCINOMAS

, 2018
The blood protein plasminogen circulates as an inactive precursor of the serine protease plasmin. Plasmin prevents aberrant formation of blood clots and protects individuals from vascular/tissue damage.
Bydoun, Moamen
core  

Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]

, 2014
Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Portelli, Michael A., Hall, Ian P., Sayers, Ian   +2 more
core  

Recombinant lys-plasminogen, but not glu-plasminogen, improves recombinant tissue-type plasminogen activator-induced coronary thrombolysis in dogs [PDF]

, 1995
Objectives.This study examined the modification of recombinant tissue-type plasminogen activator (rt-PA)-induced thrombolysis by recombinant lys-plasminogen.Background.Recombinant tissue-type plasminogen activator restores flow in the thrombosed coronary
Hedner, Ulla, Mehta, Jawahar L., Nichols, Wilmer W., Johannesen, Marie, Chen, Liying, Bregengrd, Claus, Saldeen, Tom G.P.   +6 more
core   +1 more source

Investigation of the Influence of Lipoprotein(a) and Oxidized Lipoprotein(a) on Plasminogen Activation and Fibrinolysis

Journal of Lipid and Atherosclerosis
Objective In the present study, we compare the influence of oxidized lipoprotein(a) [Lp(a)] and unoxidized Lp(a) on plasminogen activation in the process of fibrinolysis and elucidate the potential atherogenic mechanisms of oxidized Lp(a), focusing on ...
Matthew Yao, S. Kent Dickeson, Karthik Dhanabalan, Sergey Solomevich, Connor Dennewitz, David Gailani, Wen-Liang Song   +6 more
doaj   +1 more source

Activation of tissue plasminogen activator by metastasis-inducing S100P protein [PDF]

, 2017
S100P protein in human breast cancer cells is associated with reduced patient survival and, in a model system of metastasis, it confers a metastatic phenotype upon benign mammary tumour cells. S100P protein possesses a C-terminal lysine residue.
Rudland, Philip, Ismail, Thamir, Clarke, CJ, Michael Santangeli, Gross, Stephane R., Gross, SR, Ismail, TM, Rudland, PS, Roger Barraclough, Gross, Stephane R, Clarke, Christopher, Rudland, Philip S, Christopher J. Clarke, Gross, Stephane, Al-Medhtiy, M, Clarke, Christopher J, Thamir M. Ismail, Barraclough, R, Philip S. Rudland, Morteta Al-Medhtiy, Ismail, Thamir M, Stephane R. Gross, Santangeli, Michael, Barraclough, Roger, Al-Medhtiy, Morteta, Santangeli, M, Barraclough, BR   +26 more
core   +1 more source

Uso de rTPA e aspirina no tratamento de trombose intracardíaca em recém-nascido Combined rTPA and aspirin therapy for intracardiac thrombosis in neonates

Arquivos Brasileiros de Cardiologia, 2007
Descreve-se o caso de um recém-nascido prematuro de peso muito baixo, gemelar, com trombose intracardíaca. O recém-nascido apresentou quadro compatível com sepse neonatal, sendo submetido a suporte avançado de vida, terapia com antibióticos, nutrição ...
Fernanda Almeida Tardin, Antônio Carlos Avanza Júnior, Marcos Rogério Arantes Andião, Sônia Maria Alves Andrade Rabello, Emília de Mattos Gouvêa Cristello, Edna Cellis Vaccari Baltan, Edelweiss Bussinguer Pereira Pegurin, Norma Suely Oliveira   +7 more
doaj   +1 more source

FtsZ contributes to cytoadhesion and interaction with host extracellular matrix components and plasminogen in Mycoplasma bovis

Veterinary Research
Mycoplasma bovis causes serious diseases in cattle and is one of the most economically important pathogens threatening the global cattle industry. It is still a great challenge to prevent and control M.
Shanyu Jin, Shengli Chen, Huafang Hao, Shimei Lan, Xiangrui Jin, Zhangcheng Li, Xinyi Wang, Yifan Zhang, Xinmin Yan, Yuefeng Chu   +9 more
doaj   +1 more source

The Use of Low-Dose Recombinant Tissue Plasminogen Activator to Treat a Preterm Infant with an Intrauterine Spontaneous Arterial Thromboembolis

Turkish Journal of Hematology, 2015
Neonatal thromboembolic events are rare, and only a few cases of intrauterine spontaneous arterial thromboembolisms have been reported in the literature.
Yaşar Demirelli, Kadir Şerafettin Tekgündüz, İbrahim Caner, Mustafa Kara   +3 more
doaj   +1 more source