Results 61 to 70 of about 147,856 (201)

Plasminogen activation in the musculoskeletal acute phase response: Injury, repair, and disease

Research and Practice in Thrombosis and Haemostasis, 2020
The musculoskeletal system is critical for movement and the protection of organs. In addition to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated process of repair referred to as the acute‐phase response (APR ...
Breanne H.Y. Gibson, Matthew T. Duvernay, Stephanie N. Moore‐Lotridge, Matthew J. Flick, Jonathan G. Schoenecker   +4 more
doaj   +1 more source

Plasminogen-Loaded Fibrin Scaffold as Drug Delivery System for Wound Healing Applications

Pharmaceutics, 2022
Plasminogen is a protein involved in intravascular and extravascular fibrinolysis, as well as in wound healing, cell migration, tissue formation and angiogenesis.
Tamer Al Kayal, Marianna Buscemi, Aida Cavallo, Ilenia Foffa, Giorgio Soldani, Paola Losi   +5 more
doaj   +1 more source

Interaction of plasminogen and fibrin in plasminogen activation.

Journal of Biological Chemistry, 1990
Glu1-, Lys77-, miniplasminogens, kringle 1-3, kringle 1-5A, and kringle 1-5R were able to bind with fibrin, while microplasminogen and kringle 4 did not bind significantly. Kringle 1-5A, but not kringle 1-3, effectively inhibited the binding of Glu1-, Lys77-, and miniplasminogens with fibrin.
H L, Wu, B I, Chang, D H, Wu, L C, Chang, C C, Gong, K L, Lou, G Y, Shi   +6 more
openaire   +2 more sources

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

Plasminogen Assay

Clinical Chemistry, 1968
Abstract An indirect caseinolytic assay for plasminogen utilizing acid-treated plasma or serum and optimal concentrations of streptokinase is described. A linear response to increasing plasma or serum concentrations was observed. An acid-treated plasma or serum sample is preferable to euglobulin.
openaire   +2 more sources

Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II trials [PDF]

, 2009
<p><b>Background and Purpose:</b> A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies.</p> <p><b>Methods:</b> We examined patients with
Demchuk, A., Lees, K.R., Kasner, S.E., Messe, S.R., Cucchiara, B., Levine, S.R., Lyden, P., Sansing, L., Tanne, D.   +8 more
core   +1 more source

Mycoplasma synoviae LP78 is a fibronectin/plasminogen binding protein, putative adhesion, and potential diagnostic antigen

Frontiers in Microbiology
Mycoplasma synoviae (M. synoviae) is one of the major poultry pathogens causing infectious synovitis, airsacculitis, a high incidence of shell breakage, and egg production loss. However, the pathogenesis of M. synoviae remains unclear.
Shuizhong Han, Ying Wang, Lizhen Wang, Wenchi Chang, Bo Wen, Junyang Fang, Xiaolan Hou, Xuefeng Qi, Jingyu Wang   +8 more
doaj   +1 more source

DnaK Functions as a Moonlighting Protein on the Surface of Mycoplasma hyorhinis Cells

Frontiers in Microbiology, 2022
Mycoplasma hyorhinis is a common pathogen of swine and is also associated with various human tumors. It causes systemic inflammation, typically polyserositis and polyarthritis, in some infected pigs. However, the pathogenic mechanism of M.
Yao Li, Yao Li, Jia Wang, Jia Wang, Beibei Liu, Yanfei Yu, Yanfei Yu, Yanfei Yu, Ting Yuan, Yanna Wei, Yanna Wei, Yuan Gan, Jia Shao, Jia Shao, Guoqing Shao, Guoqing Shao, Guoqing Shao, Guoqing Shao, Zhixin Feng, Zhixin Feng, Zhixin Feng, Zhigang Tu, Qiyan Xiong, Qiyan Xiong, Qiyan Xiong, Qiyan Xiong   +25 more
doaj   +1 more source

Urokinase Plasminogen Activator

, 2016
The urokinase plasminogen activator system (uPAS) is an essential mechanism in a wide variety of biological processes such as fibrinoloysis, inflammation, atherosclerotic plaque formation, matrix remodeling during wound healing, tumor invasion ...
Ali Salajegheh, Salajegheh, Ali
core   +1 more source

The Deleterious Effects of Impaired Fibrinolysis on Skeletal Development Are Dependent on Fibrin(ogen), but Independent of Interlukin-6

Frontiers in Cardiovascular Medicine, 2021
Chronic diseases in growing children, such as autoimmune disorders, obesity, and cancer, are hallmarked by musculoskeletal growth disturbances and osteoporosis.
Heather A. Cole, Stephanie N. Moore-Lotridge, Stephanie N. Moore-Lotridge, Gregory D. Hawley, Richard Jacobson, Richard Jacobson, Masato Yuasa, Masato Yuasa, Leslie Gewin, Leslie Gewin, Jeffry S. Nyman, Jeffry S. Nyman, Jeffry S. Nyman, Jeffry S. Nyman, Matthew J. Flick, Matthew J. Flick, Matthew J. Flick, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker   +22 more
doaj   +1 more source