Results 21 to 30 of about 147,856 (201)
Disease Models & Mechanisms, 2021 Susceptibility to doxorubicin-induced nephropathy (DIN), a toxic model for the induction of proteinuria in mice, is related to the single-nucleotide polymorphism (SNP) C6418T of the Prkdc gene encoding for the DNA-repair enzyme DNA-PKcs.
Bernhard N. Bohnert +17 more
doaj +1 more source
Haemophilia, 2008 Summary. Plasminogen deficiency has emerged as a well‐recognized disorder in which reduced levels of plasminogen lead to the development of pseudo membranes on mucosal surfaces, with subsequent end‐organ damage of the affected tissue. Ligneous conjunctivitis is the most recognizable, well‐documented, and common presentation of the clinical syndromes ...
R, Mehta, A D, Shapiro
openaire +2 more sources
Frontiers in Molecular Biosciences, 2023 Accelerated activation of the human plasminogen zymogen (hPg) to two-chain active plasmin (hPm) is achieved following conformational changes induced by ligand-binding at the lysine-binding sites (LBSs) in four of the five hPg kringle domains.
Yetunde A. Ayinuola +2 more
doaj +1 more source
The Annexin A2/S100A10 Complex: The Mutualistic Symbiosis of Two Distinct Proteins
Biomolecules, 2021 Mutualistic symbiosis refers to the symbiotic relationship between individuals of different species in which both individuals benefit from the association.
Alamelu Bharadwaj +2 more
doaj +1 more source
Molecules, 2021 Fungi fibrinolytic compound 1 (FGFC1) is a rare marine-derived compound that can enhance fibrinolysis both in vitro and in vivo. The fibrinolytic activity characterization of FGFC1 mediated by plasminogen (Glu-/Lys-) and a single-chain urokinase-type ...
Chunli Gao +8 more
doaj +1 more source
Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]
, 2003 Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R. +19 more
core +2 more sources
Impaired Fibrinolysis in the Pathogenesis of Dengue Hemorrhagic Fever [PDF]
, 2002 The mechanisms contributing to bleeding complications in dengue hemorrhagic fever were studied by investigating the pattern of activation of the coagulation and fibrinolytic systems in 50 children with severe dengue hemorrhagic fever.
ten Cate, H +8 more
core +2 more sources
Effect of dsRNA on Mesangial Cell Synthesis of Plasminogen Activator Inhibitor Type 1 and Tissue Plasminogen Activator [PDF]
, 2009 Background/Aims: Viral infections are a major problem worldwide and many of them are complicated by virally induced glomerulonephritides. Progression of kidney disease to renal failure is mainly attributed to the development of renal fibrosis ...
Wörnle, Markus +4 more
core +1 more source
Structural basis for the pathophysiology of lipoprotein(a) in the athero-thrombotic process
Brazilian Journal of Medical and Biological Research, 1997 Lipoprotein Lp(a) is a major and independent genetic risk factor for atherosclerosis and cardiovascular disease. The essential difference between Lp(a) and low density lipoproteins (LDL) is apolipoprotein apo(a), a glycoprotein structurally similar to ...
E. Anglés-Cano
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2018 The emerging relapsing fever spirochete Borrelia (B.) miyamotoi is transmitted by ixodid ticks and causes the so-called hard tick-borne relapsing fever or B. miyamotoi disease (BMD).
Ngoc T. T. Nguyen +6 more
doaj +1 more source