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Mayo Clinic Proceedings, 1991
Despite the introduction of newer, less toxic antimicrobial agents, the aminoglycosides continue to serve a useful role in the treatment of serious enterococcal, mycobacterial, and gram-negative bacillary infections. Gentamicin, because of its low cost, remains the aminoglycoside of choice in hospitals with low levels of resistance among ...
R S, Edson, C L, Terrell
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Despite the introduction of newer, less toxic antimicrobial agents, the aminoglycosides continue to serve a useful role in the treatment of serious enterococcal, mycobacterial, and gram-negative bacillary infections. Gentamicin, because of its low cost, remains the aminoglycoside of choice in hospitals with low levels of resistance among ...
R S, Edson, C L, Terrell
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Toxicologic Pathology, 1986
Aminoglycosides are life-saving antibiotics in patients with gram negative sepsis. Renal dysfunction occurs in approximately 10% of all clinical courses of aminoglycosides. Because of close pharmacokinetic and toxicologic similarities, rats are excellent human surrogates for comparing the nephrotoxic potentials of these antibiotics. Comparisons in rats
G H, Hottendorf, P D, Williams
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Aminoglycosides are life-saving antibiotics in patients with gram negative sepsis. Renal dysfunction occurs in approximately 10% of all clinical courses of aminoglycosides. Because of close pharmacokinetic and toxicologic similarities, rats are excellent human surrogates for comparing the nephrotoxic potentials of these antibiotics. Comparisons in rats
G H, Hottendorf, P D, Williams
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Current Opinion in Otolaryngology & Head & Neck Surgery, 2007
To summarize mechanisms of ototoxicity associated with aminoglycoside antibiotics and discuss possible protective strategies.Studies in the past 15 years have demonstrated that aminoglycoside ototoxicity is mediated by an apoptotic form of cell death which employs caspase-dependent pathways. Reactive oxygen species have been demonstrated in the sensory
Mark Douglas, Rizzi, Keiko, Hirose
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To summarize mechanisms of ototoxicity associated with aminoglycoside antibiotics and discuss possible protective strategies.Studies in the past 15 years have demonstrated that aminoglycoside ototoxicity is mediated by an apoptotic form of cell death which employs caspase-dependent pathways. Reactive oxygen species have been demonstrated in the sensory
Mark Douglas, Rizzi, Keiko, Hirose
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Medical Clinics of North America, 1982
Aminoglycosides remain the cornerstone of prophylaxis and therapy against the majority of aerobic gram-negative organisms responsible for serious sepsis in the hospital. Gentamicin, tobramycin, amikacin are all equally efficacious against susceptible organisms and differ only in their patterns of resistance and pharmacokinetic profiles.
A M, Ristuccia, B A, Cunha
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Aminoglycosides remain the cornerstone of prophylaxis and therapy against the majority of aerobic gram-negative organisms responsible for serious sepsis in the hospital. Gentamicin, tobramycin, amikacin are all equally efficacious against susceptible organisms and differ only in their patterns of resistance and pharmacokinetic profiles.
A M, Ristuccia, B A, Cunha
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Plazomicin: A New Aminoglycoside.
Clinical Infectious Diseases, 2019Plazomicin (ACHN-490) is a novel parenteral aminoglycoside developed to target multidrug-resistant Enterobacteriaceae. It has recently been approved by the Food and Drug Administration (FDA) for the management of complicated urinary tract infections and ...
L. Saravolatz, G. Stein
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American Journal of Otolaryngology, 1980
Aminoglycoside antibiotics are frequently employed in the treatment of serious infections caused by aerobic gram negative bacilli. The use of these potent antibacterial agents is limited by the risks of ototoxicity and nephrotoxicity. Aminoglycosides are excreted by glomerular filtration at a rate proportional to the serum concentration. Impaired renal
S A, Lerner, G J, Matz
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Aminoglycoside antibiotics are frequently employed in the treatment of serious infections caused by aerobic gram negative bacilli. The use of these potent antibacterial agents is limited by the risks of ototoxicity and nephrotoxicity. Aminoglycosides are excreted by glomerular filtration at a rate proportional to the serum concentration. Impaired renal
S A, Lerner, G J, Matz
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Genetic susceptibility to aminoglycoside ototoxicity.
International Journal of Pediatric Otorhinolaryngology, 2019INTRODUCTION Aminoglycosides are a well-known clinically relevant antibiotic family used to treat bacterial infections in humans and animals and can produce toxic side effects.
Tien Nguyen, A. Jeyakumar
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Drugs of Today, 2003
Over the last 10 years new information has been published providing a better understanding of the risk factors, mechanism and prevention of aminoglycoside ototoxicity. The use of a higher dose and once-daily intravenous administration of aminoglycosides has shown clinical effectiveness with no increase in ototoxicity when compared to traditional ...
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Over the last 10 years new information has been published providing a better understanding of the risk factors, mechanism and prevention of aminoglycoside ototoxicity. The use of a higher dose and once-daily intravenous administration of aminoglycosides has shown clinical effectiveness with no increase in ototoxicity when compared to traditional ...
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Clinical Orthopaedics and Related Research, 1984
Aminoglycoside antibiotics continue to be indispensable in the management of complex aerobic gram-negative infections. In the United States approximately 4,000,000 patients receive this antibiotic class each year. Although the clinical efficacy of aminoglycosides is unsurpassed, these antibiotics nonetheless have an inherent tendency to produce ...
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Aminoglycoside antibiotics continue to be indispensable in the management of complex aerobic gram-negative infections. In the United States approximately 4,000,000 patients receive this antibiotic class each year. Although the clinical efficacy of aminoglycosides is unsurpassed, these antibiotics nonetheless have an inherent tendency to produce ...
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Obstetrics and Gynecology Clinics of North America, 1992
The three most commonly used aminoglycosides in obstetrics and gynecology are gentamicin, tobramycin, and amikacin. These drugs bind to subunits of the ribosome and inhibit bacterial protein synthesis. They are primarily active against aerobic gram-negative bacilli.
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The three most commonly used aminoglycosides in obstetrics and gynecology are gentamicin, tobramycin, and amikacin. These drugs bind to subunits of the ribosome and inhibit bacterial protein synthesis. They are primarily active against aerobic gram-negative bacilli.
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