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Clinical investigations of 99mTc–p-aminohippuric acid as a new renal agent

Nuclear Medicine Communications, 2009
99mTc-p-aminohippuric acid (PAH) is a new radiopharmaceutical rapidly secreted by the kidneys in a manner consistent with tubular secretion. A comparative study of renal scintigraphy and clearance with 99mTc-PAH, diethylene triamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG,) was performed.99mTc-PAH was prepared from a lyophilized kit ...
D. Djokić   +7 more
openaire   +3 more sources

p-Aminohippuric acid transport into brush border vesicles isolated from flounder kidney.

American Journal of Physiology, 1979
p-Aminohippuric acid (PAH) transport was investigated in brush border vesicles isolated from renal proximal tubules of the winter flounder. Three characteristics of carrier-mediated transport were demonstrated: 1) unlabeled PAH inhibited the uptake of ...
J. Eveloff, R. Kinne, W. B. Kinter
semanticscholar   +1 more source

Effect of splanchnicotomy on the renal excretion of para-aminohippuric acid in the anaesthetized dog

Pfl�gers Archiv European Journal of Physiology, 1977
Renal excretion of para-aminohippuric acid (PAH) was studied during PAH loading on unilaterally splanchnicotomized ("denervated") anaesthetized dogs. Urine flow, sodium excretion of denervated kidneys were significantly increased. Below a plasma concentration of 20 mg% there were no differences between intact and denervated kidneys in urinary excretion
P. Bencsath, L. Takacs, L. Szalay
openaire   +3 more sources

p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1.

Biochemical and Biophysical Research Communications - BBRC, 2000
Organic anions are secreted into urine via organic anion transporters across the renal basolateral and apical membranes. However, no apical membrane transporter for organic anions such as p-aminohippuric acid (PAH) has yet been identified. In the present
Hiroshi Uchino   +8 more
semanticscholar   +1 more source

Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1989
A procedure is described for the synthesis of p-[(bisacarboxymethyl)aminomethyl carbamino] hippuric acid (PAHIDA). The compound was identified by i.r. and NMR spectroscopy. A lyophilized complex was prepared and labeled with 99mTc. The purity of the preparation is better than 98%. The stability of the 99mTc-PAHIDA complex is achieved 8 h after labeling.
Bogdanova   +5 more
openaire   +3 more sources

Conformational profile and vibrational assignments of hippuric and 4-aminohippuric acids

Journal of Molecular Structure, 2011
Abstract The structural stability of hippuric acid and 4-aminohippuric acid was investigated for comparison purpose by the DFT-B3LYP and ab initio MP2 calculations with the 6-311G ** basis set. From the calculations at both levels of theory the near-planar Ctcnp structure was predicted to be the lowest energy minimum for the two acids.
Abdulaziz A. Al-Saadi, Hassan M. Badawi
openaire   +2 more sources

Simultaneous determination of inulin and p-aminohippuric acid (PAH) in human plasma and urine by high-performance liquid chromatography.

In Analysis, 1999
Inulin and p-aminohippuric acid (PAH) clearances are used for the estimation of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF).
N. Baccard   +5 more
semanticscholar   +1 more source

Maximum Tubular Transport of <i>p</i>-Aminohippuric Acid in Sheep

Nephron, 1971
Titration of the renal tubular secretory system for PAH was carried out in 5 unanesthetized sheep. The mean maximum rate of secretion was 2 mg/min/kg body weight.
D.T. Warren   +3 more
openaire   +3 more sources

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