Results 21 to 30 of about 3,027 (250)
The Concise Guide to PHARMACOLOGY 2023/24: Transporters
British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +27 more
wiley +1 more source
Assessment of Potential Drug-Drug Interactions for Novel Oral Melanocortin-1 Receptor Agonist Dersimelagon. [PDF]
Pharmacol Res PerspectABSTRACT Dersimelagon is a novel investigational orally administered selective agonist of the melanocortin‐1 receptor. The drug–drug interaction (DDI) potential of dersimelagon was investigated in both nonclinical (in vitro) and clinical studies. The in vitro inhibition of CYP/UGT isoforms and efflux/uptake transporters by dersimelagon was assessed ...
Ogasawara A +4 more
europepmc +2 more sources
Investigation of the Effect of Lead Adsorption on Surface Modified Fish Bones
Acta Natura et Scientia, 2020 This study investigates lead (Pb) elimination of surface modified fish bones as a biogenic apatite source. Surface modification was performed with 4-Aminohippuric acid (MBA1) and 2-Thiophenecarboxaldehyde (MBA2).
Bayram Kızılkaya, Evren Tan
doaj +1 more source
Frontiers in Pharmacology, 2021 Augmented renal clearance (ARC) observed in the critically ill pediatric population has received an increased attention over the last years due to its major impact on the disposition and pharmacokinetics of mainly renally excreted drugs.
Laura Dhondt +7 more
doaj +1 more source
The Journal of Clinical Pharmacology, Volume 63, Issue 8, Page 918-927, August 2023., 2023 Abstract Drug‐drug interaction potentials of ensitrelvir, a novel oral inhibitor of 3C‐like protease of severe acute respiratory syndrome coronavirus 2, for drug transporters were evaluated by in vitro and clinical studies. The target drug transporters assessed were P‐glycoprotein (P‐gp), breast cancer resistance protein (BCRP), organic anion ...
Ryosuke Shimizu +7 more
wiley +1 more source
Aging Cell, Volume 22, Issue 6, June 2023., 2023 This study depicted the metabolite and microbiota trajectories across aging. Long‐lived subjects from the familial longevity cohort harbored a distinguished microbiome signature. A candidate metabolite, pinane thromboxane A2 (PTA2), was consistently higher in the individuals of familial longevity and their descendants.
Junli Gong +9 more
wiley +1 more source
BMC Biology, 2020 Background Subclinical atherosclerosis may result in fatal cardiovascular (CV) events, but the underlying mechanisms and molecular players leading to disease are not entirely understood.
Marta Agudiez +8 more
doaj +1 more source
Diabetes, Obesity and Metabolism, Volume 25, Issue 1, Page 198-207, January 2023., 2023 Abstract Aim To study the effects of the sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor empagliflozin, the angiotensin receptor blocker (ARB) losartan, and their combination on blood pressure, while studying the mechanisms potentially involved. Methods A total of 24 people with type 2 diabetes (T2D) (age: 66 ± 6 years; body mass index: 31.0 ± 3 kg ...
Rosalie A. Scholtes +5 more
wiley +1 more source
Animals, 2023 Iberian pigs have low rates of muscle protein deposition compared with modern breeds. Differences in net portal appearance (NPA) of amino acids (AA) might partially explain that. NPA of AA was measured in six Iberian and six Landrace gilts (28 kg) fitted
Manuel Lachica +3 more
doaj +1 more source
SYNTHESIS OF p-AMINOHIPPURIC ACID BY MITOCHONDRIA OF MOUSE LIVER HOMOGENATES
Journal of Biological Chemistry, 1950 R K, KIELLEY, W C, SCHNEIDER
openaire +3 more sources