Results 31 to 40 of about 4,991,140 (249)

4-Aminohippuric Acid-functionalized Carbon Nanotubes for Stripping Voltammetric Determination of Copper(II) Ions

, 2016
In this study, we have demonstrated that 4-aminohippuric acid (AHA) can be coupled to acid-treated multiwalled carbon nanotubes (MWNTs) in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and Nhydroxysuccinimide (NHS) and assembled as
Alireza Mohadesi, Somayeh PARVARESH, Zarrin Es’haghi, Mohammad Ali Karimi   +3 more
openalex   +3 more sources

Influence of para-aminohippuric acid analysis on net portal-drained viscera flux of nutrients in pigs

Animal, 2017
In nutrition studies, para-aminohippuric acid (PAH) is a marker frequently used to measure blood flow in pigs, which is essential for estimating portal-drained viscera (PDV) flux of nutrients.
I. Fernández‐Fígares, M. Lachica, M. L. Rojas-Cano, Antonio González‐Casado   +3 more
openalex   +2 more sources

Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women

npj Breast Cancer, 2021
Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among ...
Oana A. Zeleznik, Raji Balasubramanian, Yibai Zhao, Lisa Frueh, Sarah Jeanfavre, Julian Avila-Pacheco, Clary B. Clish, Shelley S. Tworoger, A. Heather Eliassen   +8 more
doaj   +1 more source

Maternal dexamethasone exposure does not affect glucose tolerance but alters renal haemodynamics in F1 rats in a sex‐dependent manner

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 6, November 2023., 2023
Maternal dexamethasone treatment caused glomerular hypertrophy and a decline in renal function and effective renal plasma flow in 4‐month‐old male offspring with no changes detected in females of the same age. The expression of sodium‐glucose transporter‐2 in renal membrane fractions was not affected by dexamethasone treatment suggesting that it does ...
Slava A. Malatiali, Narayana Kilarkaje, Maie Al‐Bader   +2 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +27 more
wiley   +1 more source

Evaluation of Drug‐Drug Interactions of Ensitrelvir, a SARS‐CoV‐2 3CL Protease Inhibitor, With Transporter Substrates Based on In Vitro and Clinical Studies

The Journal of Clinical Pharmacology, Volume 63, Issue 8, Page 918-927, August 2023., 2023
Abstract Drug‐drug interaction potentials of ensitrelvir, a novel oral inhibitor of 3C‐like protease of severe acute respiratory syndrome coronavirus 2, for drug transporters were evaluated by in vitro and clinical studies. The target drug transporters assessed were P‐glycoprotein (P‐gp), breast cancer resistance protein (BCRP), organic anion ...
Ryosuke Shimizu, Takanobu Matsuzaki, Ryoko Oka, Takuhiro Sonoyama, Takahiro Fukuhara, Aya Kuwata, Yumiko Matsuo, Ryuji Kubota   +7 more
wiley   +1 more source

Identification of fecal microbiome signatures associated with familial longevity and candidate metabolites for healthy aging

Aging Cell, Volume 22, Issue 6, June 2023., 2023
This study depicted the metabolite and microbiota trajectories across aging. Long‐lived subjects from the familial longevity cohort harbored a distinguished microbiome signature. A candidate metabolite, pinane thromboxane A2 (PTA2), was consistently higher in the individuals of familial longevity and their descendants.
Junli Gong, Sanxin Liu, Shisi Wang, Hengfang Ruan, Qianqian Mou, Ping Fan, Tao Chen, Wei Cai, Yongjun Lu, Zhengqi Lu   +9 more
wiley   +1 more source

Mechanisms underlying the blood pressure‐lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes: A secondary analysis of a randomized crossover trial

Diabetes, Obesity and Metabolism, Volume 25, Issue 1, Page 198-207, January 2023., 2023
Abstract Aim To study the effects of the sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor empagliflozin, the angiotensin receptor blocker (ARB) losartan, and their combination on blood pressure, while studying the mechanisms potentially involved. Methods A total of 24 people with type 2 diabetes (T2D) (age: 66 ± 6 years; body mass index: 31.0 ± 3 kg ...
Rosalie A. Scholtes, Charlotte M. Mosterd, Anne C. Hesp, Mark M. Smits, Hiddo J. L. Heerspink, Daniël H. van Raalte   +5 more
wiley   +1 more source

The moderate‐intensity continuous exercise maintains renal blood flow and does not impair the renal function

Physiological Reports, Volume 10, Issue 15, August 2022., 2022
Abstract Exercise is restricted for individuals with reduced renal function because exercising reduces blood flow to the kidneys. Safe and effective exercise programs for individuals with reduced renal function have not yet been developed. We previously examined the relationship between exercise intensity and renal blood flow (RBF), revealing that ...
Shotaro Kawakami, Tetsuhiko Yasuno, Saki Kawakami, Ai Ito, Kanta Fujimi, Takuro Matsuda, Shihoko Nakashima, Kosuke Masutani, Yoshinari Uehara, Yasuki Higaki, Ryoma Michishita   +10 more
wiley   +1 more source

Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast‐Induced Nephropathy: A Failure of Academic Clinical Science

Clinical Pharmacology &Therapeutics, Volume 111, Issue 6, Page 1222-1238, June 2022., 2022
Contrast‐induced nephropathy (CIN) is a major complication of imaging in patients with chronic kidney disease (CKD). The publication of an academic randomized controlled trial (RCT; n = 83) reporting oral (N)‐acetylcysteine (NAC) to reduce CIN led to > 70 clinical trials, 23 systematic reviews, and 2 large RCTs showing no benefit.
Euan A. Sandilands, Jessica M. B. Rees, Khuram Raja, Neeraj Dhaun, Emma E. Morrison, Kirsty Hickson, Jonathan Wraight, Tanya Gray, Lesley Briody, Sharon Cameron, Adrian P. Thompson, Neil R. Johnston, Neal Uren, Jane Goddard, Andy Treweeke, Gordon Rushworth, David J. Webb, D. Nicholas Bateman, John Norrie, Ian L. Megson, Michael Eddleston   +20 more
wiley   +1 more source