Results 51 to 60 of about 3,020 (249)

Development of a Dynamic Physiologically Based Mechanistic Kidney Model to Predict Renal Clearance

CPT: Pharmacometrics & Systems Pharmacology, 2018
Renal clearance is usually predicted via empirical approaches including quantitative structure activity relationship and allometric scaling. Recently, mechanistic prediction approaches using in silico kidney models have been proposed.
Weize Huang, Nina Isoherranen
doaj   +1 more source

Expression of Human Organic Anion Transporters in the Choroid Plexus and Their Interactions With Neurotransmitter Metabolites

Journal of Pharmacological Sciences, 2003
: The purpose of the present study was to elucidate the expression of human organic anion transporter 1 (hOAT1) and hOAT3 in the choroid plexus of the human brain and their interactions with neurotransmitter metabolites using stable cell lines ...
Mahmoud Alebouyeh, Michio Takeda, Maristela Lika Onozato, Akihiro Tojo, Rie Noshiro, Habib Hasannejad, Jun Inatomi, Shinichi Narikawa, Xiu-Lin Huang, Suparat Khamdang, Naohiko Anzai, Hitoshi Endou   +11 more
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Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research [PDF]

, 2017
Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation.
Croubels, Siska, Delanghe, Joris, Devreese, Mathias, Gasthuys, Elke, Heyndrickx, Marjolein, Millecam, Joske, Sys, Stanislas, Vande Walle, Johan, Vanderperren, Katrien   +8 more
core   +3 more sources

Inter-study reproducibility of arterial spin labelling magnetic resonance imaging for measurement of renal perfusion in healthy volunteers at 3 Tesla [PDF]

, 2014
Background: Measurement of renal perfusion is a crucial part of measuring kidney function. Arterial spin labelling magnetic resonance imaging (ASL MRI) is a non-invasive method of measuring renal perfusion using magnetised blood as endogenous contrast ...
Delles, C., Foster, J.E., Gillis, K.A., Jardine, A.G., Mark, P.B., McComb, C., Morris, S.T.W., Patel, R.K., Roditi, G.H., Schneider, M.P., Taylor, A.H.M.   +10 more
core   +3 more sources

Effect of Acetazolamide on Obesity-Induced Glomerular Hyperfiltration: A Randomized Controlled Trial. [PDF]

PLoS ONE, 2015
Obesity is an important risk factor for the development of chronic kidney disease. One of the major factors involved in the pathogenesis of obesity-associated kidney disease is glomerular hyperfiltration.
Boris Zingerman, Michal Herman-Edelstein, Arie Erman, Sarit Bar Sheshet Itach, Yaacov Ori, Benaya Rozen-Zvi, Uzi Gafter, Avry Chagnac   +7 more
doaj   +1 more source

The Development of a Juvenile Porcine Augmented Renal Clearance Model Through Continuous Infusion of Lipopolysaccharides: An Exploratory Study

Frontiers in Veterinary Science, 2021
Augmented renal clearance (ARC) as observed in the critically ill (pediatric) population can have a major impact on the pharmacokinetics and posology of renally excreted drugs.
Laura Dhondt, Siska Croubels, Robin Temmerman, Pieter De Cock, Pieter De Cock, Pieter De Cock, Evelyne Meyer, Wim Van Den Broeck, Peter De Paepe, Mathias Devreese   +9 more
doaj   +1 more source

Allium sativum aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2014
Context: The potassium dichromate (K2Cr2O7) induces nephrotoxicity by oxidative stress mechanisms. Aims: To study the potential protection of an aqueous extract of Allium sativum against the K2Cr2O7-induced nephrotoxicity and lipid oxidation in rats ...
Sergio L. Becerra-Torres, César Soria-Fregozo, Fernando Jaramillo-Juárez, José L. Moreno-Hernández-Duque   +3 more
doaj  

Effects of dietary inclusion with rapeseed cake containing high glucosinolates on nitrogen metabolism and urine nitrous oxide emissions in steers

Animal Nutrition, 2022
Two consecutive trials were conducted to investigate the effects of glucosinolates (GLS) in rapeseed cake (RSC) on nitrogen (N) metabolism and urine nitrous oxide (N2O) emissions in steers. In trial 1, 8 steers and 4 levels of RSC, i.e.
Jian Gao, Bingbing Cheng, Yanfeng Sun, Yuchao Zhao, Guangyong Zhao   +4 more
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Impact of Zeta Potential on Copper Adsorption of Surface-Modified Hydroxyapatites Derived From Fish Bone Waste

Acta Natura et Scientia
Zeta potential emerges as a crucial parameter in understanding particle surface charges and assessing the stability of colloidal systems. It also serves as a key indicator in determining electrostatic interactions between surfaces and ions.
Bayram Kızılkaya
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Association of Noise Annoyance with Measured Renal Hemodynamic Changes

Kidney & Blood Pressure Research, 2021
Background: Chronic mental stress is recognized as a modifiable risk factor for cardiovascular disease. The aim of this study was to demonstrate that noise annoyance-induced stress is associated with changes in renal hemodynamics.
Dennis Kannenkeril, Susanne Jung, Christian Ott, Kristina Striepe, Julie Kolwelter, Roland E. Schmieder, Agnes Bosch   +6 more
doaj   +1 more source