Results 61 to 70 of about 4,991,140 (249)

Non-contrast renal magnetic resonance imaging to assess perfusion and corticomedullary differentiation in health and chronic kidney disease [PDF]

, 2016
AIMS Arterial spin labelling (ASL) MRI measures perfusion without administration of contrast agent. While ASL has been validated in animals and healthy volunteers (HVs), application to chronic kidney disease (CKD) has been limited. We investigated the
Delles, Christian, Gillis, Keith A., Mark, Patrick B., Mccomb, Christie, Morris, Scott T.W., Patel, Rajan K., Radjenovic, Aleksandra, Roditi, Giles H., Schneider, Markus P., Stevens, Kathryn K.   +9 more
core   +1 more source

The Development of a Juvenile Porcine Augmented Renal Clearance Model Through Continuous Infusion of Lipopolysaccharides: An Exploratory Study

Frontiers in Veterinary Science, 2021
Augmented renal clearance (ARC) as observed in the critically ill (pediatric) population can have a major impact on the pharmacokinetics and posology of renally excreted drugs.
Laura Dhondt, Siska Croubels, Robin Temmerman, Pieter De Cock, Pieter De Cock, Pieter De Cock, Evelyne Meyer, Wim Van Den Broeck, Peter De Paepe, Mathias Devreese   +9 more
doaj   +1 more source

Demonstration that Para-aminohippuric Acid "Enters" the Human Erythrocyte.

Experimental Biology and Medicine, 1951
Conclusions(1) Contrary to previous reports in the literature para-aminohippuric acid (PAH) has been found to “enter” the human erythrocyte at low and high plasma PAH concentrations. (2) It is pointed out that PAH plasma extraction will be falsely low and renal plasma flow estimation from the extraction values will be falsely high unless renal venous ...
Gordon B. Magill, R. C. Smith, John H. Killough, R. A. Phillips   +3 more
openaire   +3 more sources

Effect of Acetazolamide on Obesity-Induced Glomerular Hyperfiltration: A Randomized Controlled Trial. [PDF]

PLoS ONE, 2015
Obesity is an important risk factor for the development of chronic kidney disease. One of the major factors involved in the pathogenesis of obesity-associated kidney disease is glomerular hyperfiltration.
Boris Zingerman, Michal Herman-Edelstein, Arie Erman, Sarit Bar Sheshet Itach, Yaacov Ori, Benaya Rozen-Zvi, Uzi Gafter, Avry Chagnac   +7 more
doaj   +1 more source

Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney [PDF]

, 2002
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.BackgroundIndoxyl sulfate is a uremic toxin that accumulates in the body because of the patient's inability to excrete it and it induces a number of uremic ...
Asaba, Hiroshi, Deguchi, Tsuneo, Mori, Shinobu, Ohtsuki, Sumio, Otagiri, Masaki, Takanaga, Hitomi, Terasaki, Tetsuya   +6 more
core   +1 more source

Development of a Dynamic Physiologically Based Mechanistic Kidney Model to Predict Renal Clearance

CPT: Pharmacometrics & Systems Pharmacology, 2018
Renal clearance is usually predicted via empirical approaches including quantitative structure activity relationship and allometric scaling. Recently, mechanistic prediction approaches using in silico kidney models have been proposed.
Weize Huang, Nina Isoherranen
doaj   +1 more source

Association of Noise Annoyance with Measured Renal Hemodynamic Changes

Kidney & Blood Pressure Research, 2021
Background: Chronic mental stress is recognized as a modifiable risk factor for cardiovascular disease. The aim of this study was to demonstrate that noise annoyance-induced stress is associated with changes in renal hemodynamics.
Dennis Kannenkeril, Susanne Jung, Christian Ott, Kristina Striepe, Julie Kolwelter, Roland E. Schmieder, Agnes Bosch   +6 more
doaj   +1 more source

Allium sativum aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2014
Context: The potassium dichromate (K2Cr2O7) induces nephrotoxicity by oxidative stress mechanisms. Aims: To study the potential protection of an aqueous extract of Allium sativum against the K2Cr2O7-induced nephrotoxicity and lipid oxidation in rats ...
Sergio L. Becerra-Torres, César Soria-Fregozo, Fernando Jaramillo-Juárez, José L. Moreno-Hernández-Duque   +3 more
doaj  

Renal hemodynamic effects differ between antidiabetic combination strategies: randomized controlled clinical trial comparing empagliflozin/linagliptin with metformin/insulin glargine

Cardiovascular Diabetology, 2021
Background Type 2 diabetes causes cardio-renal complications and is treated with different combination therapies. The renal hemodynamics profile of such combination therapies has not been evaluated in detail.
Christian Ott, Susanne Jung, Manuel Korn, Dennis Kannenkeril, Agnes Bosch, Julie Kolwelter, Kristina Striepe, Peter Bramlage, Mario Schiffer, Roland E. Schmieder   +9 more
doaj   +1 more source

Conventional measurement of renal function utilizing serum creatinine, creatinine clearance, inulin and para-aminohippuric acid clearance

Current opinion in nephrology and hypertension, 1995
Inulin and para-aminohippuric acid clearances, determined by the conventional method of continuous intravenous infusion with blood and urine sample collections, are the gold standards for estimating glomerular filtration rate and renal plasma flow ...
Robert D. Toto
openalex   +2 more sources