A combined pig model to determine the net absorption of volatile fatty acids in the large intestine under different levels of crude fiber [PDF]
Animal Models and Experimental Medicine, 2023 Background This study aimed to develop a combined model to quantify the net absorption of volatile fatty acids (VFA) in the large intestine (LI) of pigs. Methods Fifteen female growing pigs (Duroc × Large White × Landrace) were ranked by body weight (30 ±
Shengjun Zhao +8 more
doaj +3 more sources
Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women [PDF]
npj Breast Cancer, 2021 Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among ...
Oana A. Zeleznik +8 more
doaj +3 more sources
Net Portal Appearance of Amino Acids in Iberian and Landrace Pigs Fed Different Protein Content in the Diet [PDF]
Animals, 2023 Iberian pigs have low rates of muscle protein deposition compared with modern breeds. Differences in net portal appearance (NPA) of amino acids (AA) might partially explain that. NPA of AA was measured in six Iberian and six Landrace gilts (28 kg) fitted
Manuel Lachica +3 more
doaj +2 more sources
Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging [PDF]
Aging Cell, Volume 22, Issue 12, December 2023., 2023 A comprehensive analysis of the gut metagenome and serum metabolome of individuals from a Chinese longevity cohort. We discovered distinct age‐dependent differences in both microbiota and serum metabolome. Through mediation analyses and fecal microbiota transplantation, we uncovered a potential causal relationship between the microbiota and metabolite ...
Liang Sun +55 more
wiley +2 more sources
Development of a Dynamic Physiologically Based Mechanistic Kidney Model to Predict Renal Clearance
CPT: Pharmacometrics & Systems Pharmacology, 2018 Renal clearance is usually predicted via empirical approaches including quantitative structure activity relationship and allometric scaling. Recently, mechanistic prediction approaches using in silico kidney models have been proposed.
Weize Huang, Nina Isoherranen
doaj +2 more sources
The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs [PDF]
Physiological Reports, Volume 13, Issue 1, January 2025.Abstract Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis.
Ryan Morse +6 more
wiley +2 more sources
Blood L‐cystine levels positively related to increased risk of hypertension [PDF]
The Journal of Clinical Hypertension, Volume 26, Issue 12, Page 1411-1423, December 2024.Abstract Hypertension is one component of metabolic syndrome (MetS). Here, the study evaluated hypertension‐associated metabolites in relation to other MetS components. Fasting plasma samples were collected from 22 hypertensive and 63 normotensive subjects for non‐targeted metabolomics.
Haijun Chen +7 more
wiley +2 more sources
Animal, 2017 In nutrition studies, para-aminohippuric acid (PAH) is a marker frequently used to measure blood flow in pigs, which is essential for estimating portal-drained viscera (PDV) flux of nutrients.
I. Fernández‐Fígares +3 more
openalex +2 more sources
Maturation of p-Aminohippuric Acid Transport in the Developing Rabbit Kidney: Interrelationships of the Individual Components [PDF]
Pediatric Research, 1978 Barbara R. Cole +4 more
openalex +2 more sources
Screening study of hydroxytyrosol metabolites from in vitro fecal fermentation and their interaction with intestinal barrier repair receptor AhR [PDF]
Journal of Food Science, Volume 89, Issue 12, Page 10134-10151, December 2024.Abstract Olive oil polyphenol hydroxytyrosol (HT) significantly repairs intestinal barrier function, but its absorption in the stomach and small intestine is limited. The metabolites of unabsorbed HT that reach the colon are crucial, yet their effects on colonic microbiota and intestinal barrier repair remain unclear.
Yuqing Song +7 more
wiley +2 more sources