Results 11 to 20 of about 1,689 (203)

Age-dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging. [PDF]

Aging Cell, 2023
A comprehensive analysis of the gut metagenome and serum metabolome of individuals from a Chinese longevity cohort. We discovered distinct age‐dependent differences in both microbiota and serum metabolome. Through mediation analyses and fecal microbiota transplantation, we uncovered a potential causal relationship between the microbiota and metabolite ...
Sun L, Li Z, Hu C, Ding J, Zhou Q, Pang G, Wu Z, Yang R, Li S, Li J, Cai J, Sun Y, Li R, Zhen H, Sun S, Zhang J, Fang M, Chen Z, Lv Y, Cao Q, Sun Y, Gong R, Huang Z, Duan Y, Liu H, Dong J, Li J, Ruan J, Lu H, He B, Li N, Li T, Xue W, Li Y, Shen J, Yang F, Zhao C, Liang Q, Zhang M, Chen C, Gong H, Hou Y, Wang J, Zhang Y, Yang H, Zhu S, Xiao L, Jin Z, Guo H, Zhao P, Brix S, Xu X, Jia H, Kristiansen K, Yang Z, Nie C.   +55 more
europepmc   +2 more sources

The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs. [PDF]

Physiol Rep
Abstract Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis.
Morse R, Ten Have GAM, Thaden JJ, Engelen MPKJ, Rice S, Hagve M, Deutz NEP.   +6 more
europepmc   +2 more sources

Blood L-cystine levels positively related to increased risk of hypertension. [PDF]

J Clin Hypertens (Greenwich)
Abstract Hypertension is one component of metabolic syndrome (MetS). Here, the study evaluated hypertension‐associated metabolites in relation to other MetS components. Fasting plasma samples were collected from 22 hypertensive and 63 normotensive subjects for non‐targeted metabolomics.
Chen H, Deng Y, Zhou H, Wu W, Bao J, Cao D, Li Y, Feng Y.   +7 more
europepmc   +2 more sources

Maternal dexamethasone exposure does not affect glucose tolerance but alters renal haemodynamics in F1 rats in a sex‐dependent manner

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 6, November 2023., 2023
Maternal dexamethasone treatment caused glomerular hypertrophy and a decline in renal function and effective renal plasma flow in 4‐month‐old male offspring with no changes detected in females of the same age. The expression of sodium‐glucose transporter‐2 in renal membrane fractions was not affected by dexamethasone treatment suggesting that it does ...
Slava A. Malatiali, Narayana Kilarkaje, Maie Al‐Bader   +2 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +27 more
wiley   +1 more source

Evaluation of Drug‐Drug Interactions of Ensitrelvir, a SARS‐CoV‐2 3CL Protease Inhibitor, With Transporter Substrates Based on In Vitro and Clinical Studies

The Journal of Clinical Pharmacology, Volume 63, Issue 8, Page 918-927, August 2023., 2023
Abstract Drug‐drug interaction potentials of ensitrelvir, a novel oral inhibitor of 3C‐like protease of severe acute respiratory syndrome coronavirus 2, for drug transporters were evaluated by in vitro and clinical studies. The target drug transporters assessed were P‐glycoprotein (P‐gp), breast cancer resistance protein (BCRP), organic anion ...
Ryosuke Shimizu, Takanobu Matsuzaki, Ryoko Oka, Takuhiro Sonoyama, Takahiro Fukuhara, Aya Kuwata, Yumiko Matsuo, Ryuji Kubota   +7 more
wiley   +1 more source

Identification of fecal microbiome signatures associated with familial longevity and candidate metabolites for healthy aging

Aging Cell, Volume 22, Issue 6, June 2023., 2023
This study depicted the metabolite and microbiota trajectories across aging. Long‐lived subjects from the familial longevity cohort harbored a distinguished microbiome signature. A candidate metabolite, pinane thromboxane A2 (PTA2), was consistently higher in the individuals of familial longevity and their descendants.
Junli Gong, Sanxin Liu, Shisi Wang, Hengfang Ruan, Qianqian Mou, Ping Fan, Tao Chen, Wei Cai, Yongjun Lu, Zhengqi Lu   +9 more
wiley   +1 more source

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors [PDF]

, 2013
Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde ...
Abbasalipour, V., Fozooni, S., Hamidian, H., Namjou, M., Tagizadeh, R., Taheri, A.   +5 more
core   +1 more source

Mechanisms underlying the blood pressure‐lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes: A secondary analysis of a randomized crossover trial

Diabetes, Obesity and Metabolism, Volume 25, Issue 1, Page 198-207, January 2023., 2023
Abstract Aim To study the effects of the sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor empagliflozin, the angiotensin receptor blocker (ARB) losartan, and their combination on blood pressure, while studying the mechanisms potentially involved. Methods A total of 24 people with type 2 diabetes (T2D) (age: 66 ± 6 years; body mass index: 31.0 ± 3 kg ...
Rosalie A. Scholtes, Charlotte M. Mosterd, Anne C. Hesp, Mark M. Smits, Hiddo J. L. Heerspink, Daniël H. van Raalte   +5 more
wiley   +1 more source

SYNTHESIS OF p-AMINOHIPPURIC ACID BY MITOCHONDRIA OF MOUSE LIVER HOMOGENATES

Journal of Biological Chemistry, 1950
R K, KIELLEY, W C, SCHNEIDER
openaire   +3 more sources