Results 11 to 20 of about 610 (113)

Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging

Aging Cell, Volume 22, Issue 12, December 2023., 2023
A comprehensive analysis of the gut metagenome and serum metabolome of individuals from a Chinese longevity cohort. We discovered distinct age‐dependent differences in both microbiota and serum metabolome. Through mediation analyses and fecal microbiota transplantation, we uncovered a potential causal relationship between the microbiota and metabolite ...
Liang Sun, Zhiming Li, Caiyou Hu, Jiahong Ding, Qi Zhou, Guofang Pang, Zhu Wu, Ruiyue Yang, Shenghui Li, Jian Li, Jianping Cai, Yuzhe Sun, Rui Li, Hefu Zhen, Shuqin Sun, Jianmin Zhang, Mingyan Fang, Zhihua Chen, Yuan Lv, Qizhi Cao, Yanan Sun, Ranhui Gong, Zezhi Huang, Yong Duan, Hengshuo Liu, Jun Dong, Junchun Li, Jie Ruan, Haorong Lu, Benjin He, Ninghu Li, Tao Li, Wenbin Xue, Yan Li, Juan Shen, Fan Yang, Cheng Zhao, Qinghua Liang, Mingrong Zhang, Chen Chen, Huan Gong, Yong Hou, Jian Wang, Ying Zhang, Huanming Yang, Shida Zhu, Liang Xiao, Zhen Jin, Haiyun Guo, Peng Zhao, Susanne Brix, Xun Xu, Huijue Jia, Karsten Kristiansen, Ze Yang, Chao Nie   +55 more
wiley   +1 more source

Maternal dexamethasone exposure does not affect glucose tolerance but alters renal haemodynamics in F1 rats in a sex‐dependent manner

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 6, November 2023., 2023
Maternal dexamethasone treatment caused glomerular hypertrophy and a decline in renal function and effective renal plasma flow in 4‐month‐old male offspring with no changes detected in females of the same age. The expression of sodium‐glucose transporter‐2 in renal membrane fractions was not affected by dexamethasone treatment suggesting that it does ...
Slava A. Malatiali, Narayana Kilarkaje, Maie Al‐Bader   +2 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +27 more
wiley   +1 more source

A combined pig model to determine the net absorption of volatile fatty acids in the large intestine under different levels of crude fiber

Animal Models and Experimental Medicine, Volume 6, Issue 4, Page 375-380, August 2023., 2023
This research introduced the combined model of pigs with cannulation of blood vessel and terminal ileum fistula, and the deposition of volatile fatty acids (VFA) in large intestine was determined accurately by isotope tracer method to calculate net absorption of VFA.
Shengjun Zhao, Liangkang Lv, Taotao Wu, Zhi Feng, Qiang Li, Long Lei, Zhengya Liu, Hui Zhang, Ying Ren   +8 more
wiley   +1 more source

Evaluation of Drug‐Drug Interactions of Ensitrelvir, a SARS‐CoV‐2 3CL Protease Inhibitor, With Transporter Substrates Based on In Vitro and Clinical Studies

The Journal of Clinical Pharmacology, Volume 63, Issue 8, Page 918-927, August 2023., 2023
Abstract Drug‐drug interaction potentials of ensitrelvir, a novel oral inhibitor of 3C‐like protease of severe acute respiratory syndrome coronavirus 2, for drug transporters were evaluated by in vitro and clinical studies. The target drug transporters assessed were P‐glycoprotein (P‐gp), breast cancer resistance protein (BCRP), organic anion ...
Ryosuke Shimizu, Takanobu Matsuzaki, Ryoko Oka, Takuhiro Sonoyama, Takahiro Fukuhara, Aya Kuwata, Yumiko Matsuo, Ryuji Kubota   +7 more
wiley   +1 more source

Identification of fecal microbiome signatures associated with familial longevity and candidate metabolites for healthy aging

Aging Cell, Volume 22, Issue 6, June 2023., 2023
This study depicted the metabolite and microbiota trajectories across aging. Long‐lived subjects from the familial longevity cohort harbored a distinguished microbiome signature. A candidate metabolite, pinane thromboxane A2 (PTA2), was consistently higher in the individuals of familial longevity and their descendants.
Junli Gong, Sanxin Liu, Shisi Wang, Hengfang Ruan, Qianqian Mou, Ping Fan, Tao Chen, Wei Cai, Yongjun Lu, Zhengqi Lu   +9 more
wiley   +1 more source

Mechanisms underlying the blood pressure‐lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes: A secondary analysis of a randomized crossover trial

Diabetes, Obesity and Metabolism, Volume 25, Issue 1, Page 198-207, January 2023., 2023
Abstract Aim To study the effects of the sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor empagliflozin, the angiotensin receptor blocker (ARB) losartan, and their combination on blood pressure, while studying the mechanisms potentially involved. Methods A total of 24 people with type 2 diabetes (T2D) (age: 66 ± 6 years; body mass index: 31.0 ± 3 kg ...
Rosalie A. Scholtes, Charlotte M. Mosterd, Anne C. Hesp, Mark M. Smits, Hiddo J. L. Heerspink, Daniël H. van Raalte   +5 more
wiley   +1 more source

The moderate‐intensity continuous exercise maintains renal blood flow and does not impair the renal function

Physiological Reports, Volume 10, Issue 15, August 2022., 2022
Abstract Exercise is restricted for individuals with reduced renal function because exercising reduces blood flow to the kidneys. Safe and effective exercise programs for individuals with reduced renal function have not yet been developed. We previously examined the relationship between exercise intensity and renal blood flow (RBF), revealing that ...
Shotaro Kawakami, Tetsuhiko Yasuno, Saki Kawakami, Ai Ito, Kanta Fujimi, Takuro Matsuda, Shihoko Nakashima, Kosuke Masutani, Yoshinari Uehara, Yasuki Higaki, Ryoma Michishita   +10 more
wiley   +1 more source

Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast‐Induced Nephropathy: A Failure of Academic Clinical Science

Clinical Pharmacology &Therapeutics, Volume 111, Issue 6, Page 1222-1238, June 2022., 2022
Contrast‐induced nephropathy (CIN) is a major complication of imaging in patients with chronic kidney disease (CKD). The publication of an academic randomized controlled trial (RCT; n = 83) reporting oral (N)‐acetylcysteine (NAC) to reduce CIN led to > 70 clinical trials, 23 systematic reviews, and 2 large RCTs showing no benefit.
Euan A. Sandilands, Jessica M. B. Rees, Khuram Raja, Neeraj Dhaun, Emma E. Morrison, Kirsty Hickson, Jonathan Wraight, Tanya Gray, Lesley Briody, Sharon Cameron, Adrian P. Thompson, Neil R. Johnston, Neal Uren, Jane Goddard, Andy Treweeke, Gordon Rushworth, David J. Webb, D. Nicholas Bateman, John Norrie, Ian L. Megson, Michael Eddleston   +20 more
wiley   +1 more source

In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions

Pharmacology Research &Perspectives, Volume 10, Issue 3, June 2022., 2022
Mechanistic static pharmacokinetic models predict that CYP450 inhibition and induction are unlikely for fenfluramine or its major metabolite norfenfluramine at doses used for seizure reduction (0.2−0.7 mg/kg/day). These results suggest minimal drug‐drug interaction perpetrator potential for either fenfluramine or norfenfluramine.
Parthena Martin, Maciej Czerwiński, Pallavi B. Limaye, Brian W. Ogilvie, Steven Smith, Brooks Boyd   +5 more
wiley   +1 more source