Results 31 to 40 of about 1,689 (203)

Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations [PDF]

, 2022
Organic anion transporters (OATs) belong to a subgroup of the solute carrier 22 transporter family. OATs have a central role in xenobiotic disposition affecting the toxicokinetics of its substrates and inter-individual differences in their expression ...
Dellafiora L., Dorne J. L. C. M., Louisse J.   +2 more
core   +1 more source

Mammary blood flow and metabolic activity are linked by a feedback mechanism involving nitric oxide synthesis [PDF]

, 2014
To test which, if any, of the major milk precursors can elicit a rapid change in the rate of mammary blood flow (MBF) and to define the time course and magnitude of such changes, 4 lactating cows were infused with glucose, amino acids, or triacylglycerol
Cant J.P., Cieslar S.R.L., Madsen T.G., Osborne V.R., Purdie N.G., Trout D.R.   +5 more
core   +1 more source

Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo [PDF]

, 2014
BACKGROUND: Drug transporters play important roles in the absorption, distribution, and elimination of drugs and thereby, modulate drug efficacy and toxicity. With a growing use of poly pharmacy, concurrent administration of herbal extracts that modulate
Eun Nam Kim, Hee Eun Kang, Hye Suk Lee, Hyeon-Uk Jeong, Im-Sook Song, Miwon Son, Sang-Zin Choi, Soon-Sang Kwon, Tae Yeon Kong   +8 more
core   +1 more source

Unraveling the contribution of fluid therapy to the development of augmented renal clearance in a piglet model [PDF]

, 2021
Augmented renal clearance (ARC) observed in the critically ill pediatric population has received an increased attention over the last years due to its major impact on the disposition and pharmacokinetics of mainly renally excreted drugs.
Croubels, Siska, De Cock, Pieter, De Paepe, Peter, Devreese, Mathias, Dhondt, Laura, Goethals, Klara   +5 more
core   +1 more source

Prediction of portal and hepatic blood flow from intake level data in cattle [PDF]

, 2016
There is growing interest in developing integrated post-absorptive metabolism models for dairy 30 cattle. An integral part of linking a multi-organ post-absorptive model is the prediction of nutrient 31 fluxes between organs, and thus blood flow.
Bannink, A., Crompton, Les A., Dijkstra, J., Ellis, J. L., France, J., Hanigan, M. D., Reynolds, Chris K.   +6 more
core   +1 more source

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. [PDF]

, 2019
Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects ...
Boerwinkle, Eric, Cheung, Kit Wun Kathy, Chien, Huan-Chieh, Feofanova, Elena V, Giacomini, Kathleen M, Irannejad, Roshanak, Kinchen, Jason M, Stecula, Adrian, Suhre, Karsten, van Borselen, Marjolein, Yee, Sook Wah, Yousri, Noha A, Yu, Bing, Zou, Ling   +13 more
core   +2 more sources

Demonstration that Para-aminohippuric Acid "Enters" the Human Erythrocyte.

Experimental Biology and Medicine, 1951
Conclusions(1) Contrary to previous reports in the literature para-aminohippuric acid (PAH) has been found to “enter” the human erythrocyte at low and high plasma PAH concentrations. (2) It is pointed out that PAH plasma extraction will be falsely low and renal plasma flow estimation from the extraction values will be falsely high unless renal venous ...
R A, PHILLIPS, J H, KILLOUGH, G B, MAGILL, R C, SMITH   +3 more
openaire   +2 more sources

Active Hydrophilic Components of the Medicinal Herb Salvia miltiorrhiza (Danshen) Potently Inhibit Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8) [PDF]

, 2012
Many active components of herbal products are small organic anions, and organic anion transporters were previously demonstrated to be a potential site of drug-drug interactions.
Sweet, Douglas H., Wang, Li
core   +3 more sources

Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast

, 2015
The organic anion transporter OAT4 (SLC22A11) and organic anion transporting polypeptide OATP2B1 (SLCO2B1) are expressed in the basal membrane of the placental syncytiotrophoblast.
Brooks, S., Cleal, J., Hanson, M., Lewis, R., Lofthouse, Emma, O'Kelly, Ita, Poore, K.   +6 more
core   +1 more source

Population Physiologically‐Based Pharmacokinetic Modeling to Determine Ontogeny: A Quantitative Clinical Pharmacology Example in Pediatric Rare Disease

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Pediatric physiologically‐based pharmacokinetic (PBPK) modelling plays an increasing role in selecting doses in children and addressing clinical pharmacology questions. Ethical concerns often limit clinical pharmacology studies that have no direct therapeutic benefit in children, highlighting the value of PBPK model predictions.
Yumi Cleary, Bhagwat Prasad, Kayode Ogungbenro, Michael Gertz, Aleksandra Galetin   +4 more
wiley   +1 more source